Schizophrenia Schematic Diagram

Prediscposing Factors: *Genetics *Neuro-Anatomy *Neuro-Chemical *Unknown

Precipitating Factors: *Environment *Immuno-virologic

Neuro-Chemical: *Increased Dopamine *Increased Serotonin *Excessive neurotransmitters

Neuro-Anatomy: *Decreased brain tissue and cerebospinal fluid *Ventricle enlargement *Cortical atrophy *Diminished glucose metabolism at the frontal area

*Viral Exposure *Cytokine inflammatory mediator increase *Cold environments *Triggers

Neuro-chemical changes

Changes in neural activity: Symptoms

Positive (Hard) Symptoms: *Associative Looseness *Ambivalence *Delusions *Flight of Ideas *Echopraxia *Hallucinations *Ideas of Reference *Perseveration

Negative (Soft) Symptoms *Alogia *Apathy *Blunt Affect *Catatonia *Flat Affect *Lack of Volition *Anhedonia