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Mutation is a change in the normal base pair sequence. They are a genetic disorder which means that harmful mutations in gametes are passed onto the next generation.
Types of mutations
Functionally: Harmful mutation a mutation that decreases the fitness of the organism. This type of mutation causes errors in protein sequence creating nonfunctional proteins. Example, Drosophila Melanogaster which is a name of a harmful mutation where legs grown over the head. Beneficial mutation a mutation that increases fitness of the organism or which promotes traits that is desirable. This type of mutation is use as source of all genetic variation, raw material for evolution, able to evolve & adapt to environmental changes. Example, Protection against HIV infection. Neutral mutation has no harmful or beneficial effect on the organism. Such mutation occurs at a steady rate. It occurs in amino acid codon but it has no impact. Example, a change in a base pair results in an amino acid change but the new amino acid has the same chemical properties as the old
amino acid.
Replacing an abnormal gene that causes disease with a healthy copy of the gene. Inactivating, or knocking out, a mutated gene that is not functioning properly. Introducing a new gene into the body to help fight a disease.
Although gene therapy is a promising treatment option for a number of diseases (including inherited disorders, some types of cancer, and certain viral infections), the technique remains risky and is still under study to make sure that it will be safe and effective. Gene therapy is currently only being tested for the treatment of diseases that have no other cures.
Chemotherapy
Chemotherapy is the general term for any treatment involving the use of chemical agents to stop cancer cells from growing. Chemotherapy can be administered through a vein, injected into a body cavity, or delivered orally in the form of a pill, depending on which drug is used. However, it cannot tell the difference between a cancer cell and some healthy cells. So chemotherapy eliminates not only the fast-growing cancer cells but also other fast-growing cells in your body e.g. hair and blood cells.
Radiation
Radiation therapy uses high-energy radiation to shrink tumors and kill cancer cells. X-rays, gamma rays, and charged particles are types of radiation used for cancer treatment. Radiation therapy kills cancer cells by damaging their DNA which carries genetic information. Cancer cells whose DNA is damaged beyond repair stop dividing or die. When the damaged cells die, they are broken down and eliminated by the bodys natural processes. However, radiation therapy can also damage normal cells which lead to side effects.