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Nursing 304
1. Anemia
3. Thrombocytopenia
2
b. Teeth
d. Taste Buds
1. Hypogeusia (Hypo-goo-zea)--alteration in or loss of taste
sensation due to radiation damage to tongue
2. Dysgeusia (Dis-goo-zea)--an unpleasant, usually metallic
taste
3. Aguesia (A-goo-zea)--absence of taste sensation
2. Esophagitis
4.
5.
6.
7.
8.
9.
10.
11.
12.
2. Abdomen--
a. Nausea and Vomiting
b. Abdominal cramping and diarrhea
c. Constipation
d. Cachexia
e. Intestinal obstructions
b. Moist desquamation
5. Radiation recall
6. Alopecia
D. Head
4.
5.
6.
7.
G. Renal Toxicity
H. Neurotoxicity
I. Cardiotoxicity
J. Pain
K. Body Image
O. Paraneoplastic syndrome
P. Second Malignancies
Q. Death--Hospice care
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III. Theories of the Etiology of Cancer (there are many--these are only 2)
A. Cellular Transformation and Derangement
1. Theory:
2. Agents:
B. Cell cycle
C. Contact inhibition
D. Benign--not recurrent or aggressive; does not metastasize; does not cause systemic
symptoms or death unless it interferes with vital functions due to location,
i.e. brain tumor (acoustic neuroma)
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M--metastasis
M 0 (no evidence of distant metastasis)
M 1 - 4 (ascending degree of metastasis)
G. 3 Stages of cancer cell growth
1. Initiation--something causes cell’s genetic structure to change;
a. Chemical Carcinogens--Drugs, Chemicals, Diet
b. Physical Carcinogens
1. Ionizing radiation--secondary cancer from radiation to primary cancer
2. UV radiation--short rays of sun worse
3. Foreign bodies--asbestos
4. Certain DNA and RNA viruses--oncogenic--can transform cells
i.e., HIV ------>Kaposi's Sarcoma
Hep B------->Liver cancer
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B. Education
1. Diet high in vegetables, fruits, whole grains, vitamins A and C; Limit salt-cured,
smoked, nitrite-cured foods, alcohol, fats
2. Avoid smoking, obesity, sunlight
3. Regular Physical Exam (Yearly after age 40)
4. Screening for all
a. Skin inspection for changes
b. Annual rectal exam after age 40
c. Annual stool for occult blood after age 50
d. Annual oral exam
5. Screening for women:
a. Monthly breast self-examination after age 20
b. Mammogram every 1 - 2 years between 40 and 49, then yearly
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2. Types of Radiation
a. External RT--Teletherapy
b. Internal RT
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a. Intracavity
b. Interstitial
2. Unsealed-Source RT
3. Radiation Safety
a. Time
b. Distance
c. Shielding
3. Administration Safety
a. Safe Preparation and handling
b. Safe Disposal
5.
6.
7.
8.
b. Syngeneic—identical twin
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I. Myeloid Cells
A. Erythrocytes: RBCs
B. Thrombocytes: Platelets
C. Leukocytes: WBCs
1. Monocytes:
Phagocytic
Only 4-8 % of WBCs
2nd response
2. Granulocytes
a. Neutrophils
Phagocytic
50-70% of WBCs
1st response
b. Basophils
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c. Eosinophils
Neutralize histamine
Defend against parasites
2-4 % of WBCs
E. Biologic Response Modifiers--Biotherapy, obtained through genetic engineering.
a. Purpose is to strengthen and manipulate the immune system.
b. Examples of Biologic Response Modifiers:
1. Monoclonal antibodies (MoAbs)--used diagnostically to identify
tumor cells, as a delivery agent of radioisotopes to tumor site, and
to deliver immunotoxins to tumor site
2. Interferons (IFN)--small proteins with cellular activity in three areas:
antiviral, immunomodulatory, and antiproliferative
3. Interleukins--produced by lymphocytes and function to
promote normal hematopoiesis. Responsible for growth of
T
cells. Side effects as well as desirable effects. (Ex: capillary leak
syndrome leading to edema.)
4. Colony stimulating factors (CSF)--do not treat cancer but help with
negative effects of treatment
a. Erythropoietin (EPO)--FDA approved; affects erythrocyte
production; Also used in clients with anemia in end
stage renal failure. Procrit or Epogen.
b. Neupogen