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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review
Gascoyne, R.D. et al., Lamant, L. et al., Lai, R. et al., Touriol, C. et al., Morris, S.W. et
al., et al.
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paraffin-embedded specimens of CD30+ lymphomas from the United States and Hong Kong by reverse transcriptase-polymerase chain reaction (RT-PCR) for the status of the NPM and ALK genes, which are typically juxtaposed by the t(2;5) translocation [16]. Whilst the strong labelling for phosphotyrosine observed in the lymphoma cells is due to the presence of activated ALK, the strong staining of some normal cells presumably represents physiologically active kinases and this should be taken into account when interpreting the immunostaining of non-lymphoid tumours [17].
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complexes of approximately 200 kDa or greater that also contain normal NPM [27].
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References
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Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway. Bai, R.Y., Ouyang, T., Miething, C., Morris, S.W., Peschel, C., Duyster, J. Blood (2000) 19. ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases. Gascoyne, R.D., Lamant, L., Martin-Subero, J.I., Lestou, V.S., Harris, N.L., Mller-Hermelink, H.K., Seymour, J.F., Campbell, L.J., Horsman, D.E., Auvigne, I., Espinos, E., Siebert, R., Delsol, G. Blood (2003) 20. Bcl-XL down-regulation suppresses the tumorigenic potential of NPM/ALK in vitro and in vivo. Coluccia, A.M., Perego, S., Cleris, L., Gunby, R.H., Passoni, L., Marchesi, E., Formelli, F., Gambacorti-Passerini, C. Blood (2004) 21. Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits,
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