Chem-301 Chapter - Metabolism Model questions Which reaction is not involved in phase 1 metabolism a. oxidation b. reduction c. acetylation d.

hydrolysis 2. Which function group is not formed in phase 1 metabolism of xenobiotics a. carboxylic acid b. hydroxyl c. amino d. methyl 3. oxidative metabolism on of C-S systems in organic compound produces a. S-dealkylation, b. S-oxidation c. desulfuration d. sulfhydrylation 4. Which one given below is not site for drug metabolism. a. intestinal mucosa, b. kidney, c. adrenal glands, d. heart 5. Which one in the following is not involved in oxidative metabolism a. cytochrome P-450 monooxygenase b. cytochrome P-450 reductase c. NADPH d. ATP 6. Oxidation of olefinic Carbon-carbon double bond first forms a. epoxide b. trans 1,2-diols c. alkane d. alcohol 7. Important metabolic pathway of halothane is a. Oxidative dehalogenation b. Oxidation c. Dehalogenation d. Reduction 8. Which statement is false a. reduction of aldehyde gives primary alcohol b. reduction of ketone gives secondary alcohol c. oxidation of aldehyde gives carboxylic acid d. oxidation of azo gives nitro compound 9. Which one is not much involved in conjugation reaction in human being a. glucuronic acid 1.

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b. sulfate c. glycine d. glutamine Glucuronic acid conjugation does not involve any one of the following a. synthesis of active coenzyme UDPGA b. transfer of glucuronyl group to the substrate by the enzyme UDP-glucuronyl-tranasferase c. activation of substrate by the coenzyme PAPS d. Phenolic group Heparin is mainly undergoes phase 2 metabolism via a. Sulphate conjugation b. Glycine conjugation c. Glutathione conjugation d. Glucuronic acid conjugation Coenzyme involved in sulphate conjugation is a. 3-phospho-adenosine-5-phosphosulfate b. sulfotranasferase c. Adenosine triphoshate d. Acetyl Coenzyme A Which is not true in statement of glutathione a. It is a tripeptide consisting of -glutamyl-cysteinyl-glycine b. Cytoplasmic enzyme glutathione S-transferase catalyzes its conjugation c. Biotansformation with glutathione gives S-substituted Nacetylcysteine called as mercapturic acids. d. Glutathione does not conjugate with reactive electrophiles Which group is not acetylated in phase 2 meatabolism a. amino group b. hydrazines c. sulfonamides d. primary alcohols Which one is not correct in methylation reaction a. coenzyme invovled in methylation is S-adenosylmethionine (SAM). b. Microsomal methyl-transferase enzyme transfer activated methyl group from coenzyme to acceptor substrate. c. Catechol-O-methyltransferase (COMT) helps in methylation d. Methylation render the molecule more polar What is not true in the case of enzyme induction? a. The process by which the activity of certain drug metabolizing enzymes is increased is termed as enzyme induction. b. Enzyme induction increases the rate of drug metabolism and decreases the duration of drug action. c. The inducing agent may increase the rate of their own metabolism as well as those of others leading to serious drug interactions.

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d. Induction of microsomal enzyme by pheno-barbitone, decreases the metabolism of warfarin. Which statement is false in mechanism of enzyme inhibition a. substrate competition, b. interference with protein synthesis, c. inactivation of drug metabolizing enzyme. d. Inhibition of enzyme induction