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Diagrams:

Diagram I Pathogenesis of Insulin Dependent DM (Type 1)


Genetic Predisposition (Susceptibility)

Environmental insult - Viral infection - Toxic chemical agents

Autoimmunity -Lymphocyte infiltration -Insulitis

Immunologic Response

Islet cell antibodies Cell- mediated immunity

cell destruction

Lack of insulin release

Insulin Dependent Diabetes Mellitus (IDDM)

Diagram II Pathogenesis of Non- Insulin Dependent DM (Type 2)


Hereditary Factors Obesity

Delayed or insufficient insulin secretion

Insulin resistance (Receptor defect or other events)

Increased insulin demand

cell exhaustion and dysfunction

Impaired secretion of insulin

Hyperglycemia

Non- Insulin Dependent DM (NIDDM)

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