Section A:

Cardiovascular pharm L3 - Multiple Choice (Choose the ONE best answer)

(e)Nifedipine

1.

Which of the following hypotensive drugs could cause sedation and drowsiness? (a)Methyldopa (b)-blockers (c) Captopril (d)Nifedipine (e)prazosin A bradykinin mediated adverse of Angiostensin Converting Enzymes Inhibitors (ACEI) is (a)Renal insufficiency (b)Metabolic acidosis (c)Palpitations (d)Cough (e)Hypokalemia Which of the following disorders is(are) contra-indication(s) of Angiostensin Converting Enzymes Inhibitors? (a)Heart failure (b)Diabetic nephropathy (c)Non-diabetic nephropathy (d)Severe dehydration (e)All of the above How could you explain the anti-arrhythmic action of -adrenoceptor antagonists? (a)Depress SA node, (b)Slow AV conduction (c)Reduce heart rate (d)None of the above (e)All of the above Digoxin is effective in the treatment of which of the following types of arrhythmias? (a)Bradycardia (b)Ventricular ectopic beats (c)Atrial fibrillation (d)Heart failure (e)Ventricular fibrillation Which of the following calcium blocking drug is relatively cardioselective? (a)Nifedipine (b)Acebutolol (c)Verapamil (d)Amlodipine (e)propanolol The use of calcium channel blockers as anti-angina could be explained by the following property: (a)Stabilization of blood pressure (b)Increase in coronary blood follow (c)Prevents hypokalemia (d)Increase in contractility of myocardium (e)Reduction in the secretion of rennin Which of the following anti-hypertensive agent is most likely to cause hyperuricemia

9.

2.

Gynecomastia is the adverse effects of which of the following drug? (a)Amiloride (b)Thiazides (c)Digoxin (d)Spironolactone (e) Furosemide Which of the following is TRUE about the -adrenergic agonist, Dobutamine (a)Indicated for the treatment of odema of cardiovascular origin (b)Improves cardiac output mainly by increasing blood volume. (c)Improves cardiac output mainly by increasing heart rate (d)Produce less tachycardia than other -adrenergic agonists (e)Contraindicated in Asthma Which of the following is true for the use of digoxin in patients with renal insufficiency? (a)Digoxin is contra-indicated (b)Digoxin causes potassium retention (c)Increased risk of digoxin toxicity (d) Digoxin stimulates dieresis (e)Digoxin reduces renin secretion What is the clinical use of gylceryl trinitrate? (a)Prophylactic treatment of angina pains (b)Acute treatment of angina pains (c)Treatment of hypertension (d)Treatment of hypotension (e)Treatment of shock A major contra-indication of -blockers is (a)Gout (b)Arthritis (c)Bradycardia (d)Heart failure (e)Tachycardia The peripheral -blockers, doxazosin is best for the treatment of which of the following conditions? (a) Hypertension in diabetic patients (b)Hypertension in patients with renal insufficiency (c)Hypertension in patients with gout (d)Hypertension in patients with benign prostatic hypertrophy (e)Hypertension in patients with asthma What is a clinical use of the peripheral vasodilator hydralazine? (a)Myocardiac Infarction (b)Heart failure (c)Eclampsia (d)Mild hypertension (e)Hypotension ___________________________________________________________________________ Section B: (6pts). Open Questions

10.

3.

11.

4.

12.

5.

13.

6.

14.

7.

15.

8.

(a)

Captopril (b)Spironolactone (c)Propranolol (d)Hydrochlorothiazide

16.

Compare the pharmacology effects and adverse effects of What are the differences between Angiostensin Converting Enzymes
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17.

Inhibitors (ACEI) and Angiostensin Receptors Blockers (ARB) (3pts) What are the effects on lipids and adverse effects of statins hypolipidemic drugs? (2pts)

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