Evaluation: Pharmacology UY1/FMSB/PHCL200-L2S4/PHARM 28june2011: 60mins __ __ / 20pts Section A: Multiple Choice (Choose the ONE best answer)

[e] None of the Above

5. Which route of administration could represent oral route?

[a] A [b] B [c] C [d] D [e] None of the Above

6. What is the F value for an experimental drug tablet based on the following data?
[a] 0.25 [b] 0.38 [c] 0.50 [d] 0.67 [e] 0.90

B C D

7. A drug has an elimination half-life of 3 hours and its apparent volume of distribution is 100
mL/kg. What is the total body renal clearance of this drug in a 70-kg male in terms of liters per hour? [a] 0.5 L/hr [b] 1.6 L/hr [c] 8 L/hr [d] 14.6 L/hr [e] 16.3 L/hr 8. What characteristic(s) could make an adverse drug reaction to be considered as serious? [a] An adverse drug reaction that results in congenital malformation [b] An adverse drug reaction that results in death [c] An adverse drug reaction that results in hospitalisation [d] An Adverse drug reaction that results in disability [e] All of the above 9. Which of the following is true concerning rectal administration of drugs [a] Gives predictable blood levels [b] From lower 1/3rd avoids first pass & upper 2/3rds doesnt [c] None undergoes first pass metabolism [d] All of it undergoes first pass metabolism [e] None of the above

The above figure shows plasma concentration against time curves following the administration of a drug through different routes; A, B, C, & D . Answer questions 1-5 below referring this figure

1. In which route of administration is the rate of absorption is less than the rate
of elimination? [a] A [b] B [c] C [d] D [e] None of the Above 2. Which route of administration could represent sub-lingual route? [a] A [b] B [c] C [d] D [e] None of the Above 3. Which route of administration could represent dermal route? [a] A [b] B [c] C [d] D [e] None of the Above 4. Which route of administration could represent intravenous route? [a] A [b] B [c] C [d] D

10. Which of these processes may not be involved in pharmacokinetic drug interactions [a] Absorption [b] Metabolism [c] Distribution [d] Excretion [e] None of the Above
Section B: OPEN Questions -

11. Cite 3 therapeutic consequences of drug-drug interactions and give that respective examples (6pts) 12. Cite 2 adverse drug reactions that related to the pharmaceutical phase of drug administration (2pts)
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13. Describe 5 important information or facts related to adverse drug event reporting that are expected to be included in the National Adverse Effect Event Reporting Form of the Ministry of Public in Cameroon (6 pts) 14. Describe non-receptor mechanisms through which a drug substance can induce tissue injury (4pts) 15. Give a tabulated comparison (similarities and differences) between pharmacology and toxicology (6pts) 16. Give 4 reasons why clinical trials are important in making therapeutic recommendations? (6 pts)

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1. D 2. B 3. D 4. A 5. C 6. A 7. B 8. E 9. B 10. E 11. 12. 13. 14.

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