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Goals:
By the end of this lecture, you should be able to:
• List and describe some of the common natural materials
used in TE
• Describe how cells interact with the surrounding ECM
• Describe how these interactions can be modulated
• Define "biomimetic"
• Define "Vroman effect"
• Describe the biological responses to implanted materials
• Describe common methods to assess biocompatibility
Outline:
I. Natural Materials in Tissue Engineering
II. Cell Interactions with Materials
III. Controlling Cell Interactions - "Biomimetic" Materials
IV. Analysis of Material Biocompatibility
BME 379/385, CHE 379: Biomaterials II -- 2
Function Structure
Bioactivity Support
Shape
Interactions:
Material ECM
Cell
BME 379/385, CHE 379: Biomaterials II -- 4
Chemotaxis:
Chemoaffinity:
Blood cells consist of white blood cells (leukocytes) and red blood
cells. Granulocytes (eosinophils, basophils, neutrophils), monocytes
(macrophages), and lymphocytes together comprise white cells.
Red blood cells are biconcave discs that lack a nucleus and carry
hemoglobin which is responsible for oxygen transport.
Acute Inflammation:
Chronic Inflammation:
Granulation Tissue:
Inflammation:
Define biocompatibility?
Infection:
Immune response:
Biocompatibility testing: