Renin-Angiotensin System

Beta Blockers Liver

Angiotensinogen

Kininogens Kidney Renin neutral endopeptidase

Angiotensin (1-7)
Plasma Kallikrein Angiotensin I Receptor 3
Big endothelin AT 3
Chymase prolylendeptidase Vasodilation & potentiate
BKB 2 Bradykinin Endothelin I bradykinin
Receptor Substance P
Vasodilation , release of nitric oxide,
prostacyclin, and endothelium
ACE Capillary Inhibition of

derived hyperpolarizing factor,

Angiotensin Converting Enzyme Adrenal Cortex Aldosterone
Metabolsim
inhibition of platelet adhesion, and
Inactive Peptides Angiotensin II
inhibition of smooth muscle ACE Inhibitors
proliferation. Angiotensin II Receptor

Angiotensin II Aldosterone
Receptor 1 Secretion
AT 1
Angiotensin II
Systemic Vasoconstricition & expression of Receptor
Plasminogen Activator Inhibitor-1 Blockers

Angiotensin III

Arginylaminopeptidase Sodium resorption from the

Glutamylaminopeptidase
Posterior pituitary kidney distal kubules
Angiotensin IV
Vasopressin
release Lumen
Angiotensin IV(3-8)
Receptor 4
AT 4 Angiotensin II Sodium
Na +
Learning and memory Receptor 2 Channel
AT 2
Vasodialation & Apoptosis
Sodium
Channel
Modulators Aldosterone
Receptor