CURRICULUM VITAE A. R. M.

RUHUL AMIN MAILING ADDRESS: 1538D Woodlake Drive Atlanta, GA 30329 Phone: 404-461-9007 (H) 404-210-2102 (C) 404-778-5691 (W) Fax: 404-778-5520 E-mail: amin9@emory.edu CAREER OBJECTIVE: To build up career as a Molecular Biologist and Cell Biologist, particularly in the field of Cancer Biology and Drug Development and in teaching. PRESENT POSITION: Senior Research Associate (Junior Faculty), Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta CURRENT RESEARCH: Development of new chemopreventive and chemotherapeutic strategy for the prevention and treatment of Squamous Cell Carcinoma of the Head and Neck (SCCHN) and Lung Cancers. Drug associated toxicity is one of the major barrier to achieve therapeutic goals with currently available drugs. In majority of cases, drug associated toxicity is due to the use of high doses of the drugs to eliminate cancer cells. Because of the safety, low toxicity, antioxidant property and general acceptance as dietary supplements, fruits, vegetables and other dietary elements (mainly used as spices) drew much attention for the purpose of new drug development for chemoprevention. However, the bioavailability of natural products is limited and again high doses are needed to achieve the effective concentrations in vivo which sometimes produce toxicity. In order to resolve these issues, I hypothesize that combination of one natural compound with another natural compound or combination of natural compound with currently available drug at lower doses having synergistic growth inhibitory properties might be a good approach. Using lower doses of natural compounds having either no or very little apoptotic effect as single agent, but with significant synergistic apoptotic effect when combined with another such compound might eliminate many of the drug associated toxicities and it will be more easier to achieve the effective drug concentration in vivo. However, the challenge is to find out effective combinations. I have already established several such combinations. Now I am working to find out their in vitro mechanism of actions and to study their efficacy in nude mice xenograft models before further development of Phase I clinical trials. Specific targets for mechanistic study
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Role of p73 in cell cycle arrest and apoptosis : p53 is the major tumor suppressor of the

body that play a pivotal role in controlling the cell cycle, apoptosis, genomic integrity and DNA repair in response to various forms of genotoxic stress. Unfortunately, p53 is deleted in more than 50% of all human cancers and functionally inactivated in another 20%. It is my understanding

that a compound/gene capable of inducing cell death in the absent of functional p53 holds strong promise as a chemotherapeutic agent or target for chemotherapeutic drug development. Unlike p53, its family member p73 is found functional in most cancers and p73 mutation in human cancers is extremely rare. However, the high degree of structural similarity with p53, p73 is reflected by a significant overlap of function, as p73 can activate several p53-responsive genes, thus leading to induction of cell cycle arrest and apoptosis. Activation of p73 is sufficient to trigger apoptosis independently of p53. Thus, p73 is considered as an important target for anticancer drug development. The primary focus of my current research is to understand the p53 signaling network and identify compounds capable of inducing cell death in the absent of functional p53 and the response of these cells to the compounds after reintroduction of p53 or inactivation of p73 in these cells. I have found that many of the compounds I used are capable to activate p73. Now I am working to establish by using genetic approaches that p73 is indeed responsible for the synergistic anti-tumor effect and the mechanism of activation of p73.
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Akt-Foxo1a Signaling Cascade: Foxo1a is a transcription factor that can be activated in

response to DNA damage and oxidative stress and drives the expression of genes important for cell cycle arrest (p21, p27, Cyclin G2) and apoptosis (Bim, Puma). Akt-dependent phosphorylation of Foxo1a excludes it from the nucleus and makes transcriptionally inactive. Constitutive anctivation of Akt is observed in many cancers. A great majority of natural compounds or chemotherapy drugs inhibit constitutive activation of Akt. I found that treatment with tyrosine kinase inhibitor Erlotinib and green tea constituent EGCG, activates p21, p27, Puma and Bim in a p53-independent manner along with inhibition of Akt. I am now working to study the role of Akt-Foxo1a signaling and their mechanism of activation in Erlotinib-EGCG-induced apoptosis. Goals: The goals of my current research is to find out compounds which are capable of inducing apoptosis in the absence of functional p53 and identify molecular targets which are important for apoptosis in the absence of p53. TEACHING EXPERIENCE: September 30, 1996- October 19, 1998: Lecturer, Department of Pharmacy, Rajshahi University, Banglaseh. I taught Microbiology and Pharmacology Courses for the undergraduate and graduate students.
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October 01, 1999- January 28, 2004: Assistant Professor, Department of Pharmacy, Rajshahi University, Banglaseh. During this period, I was on study leave to study in Japan. 3. January 29, 2004- May 19, 2004: Associate Professor, Department of Pharmacy, Rajshahi University, Banglaseh. I taught Microbiology, Pharmacology, Molecular Biology and Biotechnology courses for B. Pharm. students.
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MENTORING: I supervised the M. Sc and M. Pharm. thesis of three students. One of my students isolated two novel compounds from a soil microorganism. These compounds were reported in Tetrahedron Letters, the no. 1 letters journal in chemistry and enlisted the Molecular Target Development Program, NCI. BIBLIOGRAPHY: 1. August 12, 1995- September 23, 1996: Production Officer, Beximco Pharmaceuticals Ltd. Bangladesh 2. September 30, 1996- October 19, 1998: Lecturer, Department of Pharmacy, Rajshahi University, Banglaseh. 3. October 21, 1998- March 31, 1999: Research Student, Nagoya University School of Medicine, Japan 4. April 01, 1999- March 31, 2003: Ph. D. Student, Nagoya University School of Medicine, Japan 5. October 01, 1999- January 28, 2004: Assistant Professor, Department of Pharmacy, Rajshahi University, Banglaseh. 6. January 29, 2004- May 19, 2004: Associate Professor, Department of Pharmacy, Rajshahi University, Banglaseh. 7. May 25, 2004- December 31, 2005: Research Scholar, Department of Genetics, Case Western Reserve University 8. January 01, 2006 to July 31, 2007: Research Associate, Department of Genetics, Case Western Reserve University 9. August 01, 2007 to date: Senior Research Associate, Department of Hematology and Medical Oncology, Emory Winship Cancer Institute, Atlanta, Georgia EDUCATIONAL QUALIFICATION Doctor of Philosophy: Awarded on March 25, 2003 from Department of Molecular Pathogenesis, Nagoya University School of Medicine, Japan with grade A in all the required courses. Supervisor: Prof. Michinari Hamaguchi. Research Area: Signal transduction. Study the role of SHPS-1 and SHP2 in signal transduction and also study the critical signaling required for the secretion and activation of MMP-2 and 9. M. Pharm: 1991. Completed 1 year M. Pharm course from the Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh. Secured first class 2nd position with 65% marks. Subject Studied: Advanced Pharmaceutical Analysis; Medicinal Chemistry, Pharmacology & Toxicology; Biopharmaceutics. Thesis Title: Studies on a Penicillium species. Thesis Supervisor: Professor Dr. Md. Abdul Jabbar, Prof. Emeritus, Department of Pharmacy, Dhaka University, Bangladesh. Medium of instruction: English.

B. Pharm (Hons.): 1990. Completed 3 years B. Pharm. (Honours) course from the Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh. Secured first class 2nd position with 67% marks. Subjects Studied: Inorganic, Organic & Physical Pharmaceutical Chemistry, Pharmacognosy, Physiology & Biochemistry, Pharmaceutical Microbiology, Statistics, Pharmacology, Pharmaceutics, Pharmaceutical Analysis & Quality Control, Medicinal Chemistry, Industrial & Hospital Pharmacy, Pharmacokinetics & Biopharmaceutics. Medium of instruction: English. Higher Secondary Certificate (H. S. C.): 1987. Jaypurhat Govt. College, Rajshahi Board, Bangladesh. Secured first division with 77.2% marks. Subject Studied: Bengali (Language & Literature), English (Language & Literature), Physics, Chemistry, Biology (Botany & Zoology) and Mathematics. Secondary School Certificate (S.S.C.): 1985. Kamar Khali High School, Dhaka Board, Bangladesh. Secured first division with 70.6% marks. Subject Studied: Bengali (Language & Literature), English (Language & Literature), General Science (Physics & Chemistry), Biological Science (Botany & Zoology), Mathematics (General & Higher), Geography and Religious Education. EXPERIMENTAL PROCEDURES WORK WITH: Cell culture, Cell treatment with chemicals, Plasmid construction, Plasmid purification, Plasmid transfection, SDS-PAGE, Western blotting, Northern blotting, Southern blotting, PCR, RT-PCR, Real time PCR, DNA sequencing, Zymography, Immunoflourescence, Electrophoretic Mobility Shift Assay (EMSA), Immunoprecipitation, TUNNEL assay, PI staining for cell cycle analysis, ProteinProtein interaction study, Use of Radio-isotope, infection of cells with lenti and retro viruses. Development of tumor in nude mice, handling nude mice, i.p. injection of drugs to nude mice, Oral gavage to deliver drug. Culture of microorganisms, Extraction of microbial metabolites, Thin layer chromatography, Column chromatography, Anti-microbial assay of chemical compounds (both qualitative and quantitative), Cytotoxicity assay by brine shirmp lethality bio-assay. TRAINING OBTAINED 1. International training course on Molecular Biology of Cancer Cells. 6-17 July, 1998. Organized by International Cell Research Organization (ICRO) in Nagoya, Japan 2. 4 weeks in-plant training in Rhone Paulenc Rorer, Bangladesh Ltd. 3. 3 days training on Pharmaceutical Marketing, organized by Pharmacy Graduates Association, Bangladesh SCHOLARSHIP/AWARDS 1. Japanese Govt. Monbusho Scholarship for doctoral course 2. ICRO/UNESCO fellowship to attend International training course on Molecular Biology of Cancer Cells

3. Two times awarded travel grants from the Department of Molecular Pathogenesis, Nagoya University School of Medicine to present in conferences in USA and Greece 4. Bangladesh Govt. Scholarship for outstanding result in B. Pharm. Examination 5. Bangladesh Govt. Scholarship for outstanding result in H. S. C. Examination 6. Bangladesh Govt. Scholarship for outstanding result in S. S. C. Examination 7. Junior Scholarship given by Bangladesh Govt. 8. Primary Scholarship given by Bangladesh Govt. 9. Mazedul Islam Education Trust Scholarship in 1992 MEMBERSHIP OF PROFESSIONAL BODIES 1. Associate member, American Association for Cancer Research 2. Registered Pharmacist of Pharmacy Council of Bangladesh. 3. Member, American Bangladeshi Pharmacist Association AD-HOC REVIEWER 1. Cancer Letters 2. Dhaka University Journal of Pharmaceutical Sciences LANGUAGE PROFICIENCY 1. Bengali: Reading, Writing and speaking 2. English: Reading, Writing, Speaking PERSONAL INFORMATION Fathers Name: Late Md. Hatem Ali Mollah Permanent Address: Vill. Komorpur P. O. Kamar Khali P. S. Modhu Khali Dist. Faridpur Bangladesh Date of Birth: November 27, 1969 Country of Birth: Bangladesh Country of Citizenship: Bangladesh Immigration Status: US permanent resident Marital Status: Married

LIST OF PUBLICATIONS
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Kedar Hastak, Rajib K Paul, Mukesh K Agarwal, Vijay S Thakur, A. R. M. Ruhul Amin, Sudesh Agarwal, R Michael Sramkoski, James W Jacobberger, Mark W Jackson, George R Stark and Munna L Agarwal. DNA Synthesis from Unbalanced Nucleotide Pools Causes Limited DNA Damage that Triggers ATR-CHK1-Dependent p53 Activation. PNAS, 105: 6314-9. 2008 A. R. M. Ruhul Amin, M Helal Uddin Biswas, Takeshi Senga, Gen-Sheng Feng, Reiji Kannagi, Munna L Agarwal and Michinari Hamaguchi. A role for SHPS1/SIRP in concanavalin A-dependent production of MMP-9. Genes to Cells, 12:1023-1033. A. R. M. Ruhul Amin, Rajib K Paul, Vijay S Thakur and Munna L Agarwal. A Novel Role for p73 in the Regulation of Akt-Foxo1a-Bim Signaling and Apoptosis Induced by Concanavalin A. Cancer Research, 67: 5617-5621 (Priority Report). A. R. M. Ruhul Amin, Vijay S Thakur, Rajib K Paul, Gen Sheng Feng, Hasan Mukhtar and Munna L Agarwal. SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53-target genes induced by the green tea polyphenol EGCG. PNAS, 104: 5419-5424, 2007. A. R. M. Ruhul Amin, Mukesh K Agarwal and Munna L Agarwal. DNA replication licensing factor (MCM5) rescues p53-mediated growth arrest. Cancer Research. 67: 116-121, 2007. Md. Helal Uddin Biswas, Hitoki Hasegawa, M. Aminur Rahman, Pengyu Huang, Naing Naing Mon, A. R. M. Ruhul Amin, Takeshi Senga, Reiji Kannagi and Michinari Hamaguchi. SHP-2-Erk signaling regulates Concanavalin A-dependent production of TIMP-2. Biochemical Biophysical Research Communication. 348: 1145-9, 2006. A. R. M. Ruhul Amin, Myat Lin Oo, Takeshi Senga, Noriko Suzuki, Gen-Sheng Feng and Michinari Hamaguchi. SHP-2 regulates Concanavalin A-dependent secretion and activation of MMP-2 via the Erk and p38 pathways. Cancer Research. 63: 63349, 2003 A. R. M. Ruhul Amin, Takeshi Senga, Myat Lin Oo, Aye Aye Thant and Michinari Hamaguchi. Secretion of matrix metalloproteinase-9 by the proinflammatory cytokine, IL-1: a role for the dual signaling pathways, Akt and Erk. Genes to Cells. 8:515-23. 2003 Myat Lin Oo, Takeshi senga, Aye Aye That, A. R. M. Ruhul Amin, Pengyu Huang, Naing Naing Mon and Michinari Hamaguchi. Cysteine residues in the C-terminal lobe of Src: their role in the suppression of the Src kinase. Oncogene. 22:1411-7. 2003 A. R. M. Ruhul Amin, Yasukatu Ichigotani, Myat Lin Oo, Md. Helal Uddin Biswas, Hong Yuan, Pengyu Huang, Naing Naing Mon and Michinari Hamaguchi. The PLCPKC cascade is required for IL-1-dependent Erk and Akt activation: their role in proliferation. International Journal of Oncology. 22:1727-32, 2003 A. R. M. Ruhul Amin, Kazuya Machida, Kumi Oshima, Myat Lin Oo, Aye Aye Thant, Takeshi Senga, Satoru Matsuda, Anwarul Azim Akhand, Akito Maeda,

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Tomohiro Kurosaki and Michinari Hamaguchi. A role for SHPS-1/SIRP1 in IL-1and TNF-dependent signaling. Oncogene. 21:8871-8. 2002. Kumi Osima, A. R. M. Ruhul Amin, Atsushi Suzuki, Michinari Hamaguchi and Satoru Matsuda. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Letters. 519:1-7. 2002. Review. Aye Aye Thant, Akihiro Nawa, Fumitaka Kikkawa, Yasukatu Ichigotani, Yangying Zhang, Thet Thet Sein, A. R. M. Ruhul Amin and Michinari Hamaguchi. Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3KAkt pathways in ovarian cancer cells. Clinical and Experimental Metastasis. 18: 423-8, 2001. Thet Thet Sein, Aye Aye Thant, Yukiko Hiraiwa, A. R. M. Ruhul Amin, Yoshihiro Shohara, Yuzhen Liu, Satoru Matsuda, Tadashi Yamamoto and Michinari Hamaguchi. A role for FAK in the Concanavalin A-dependent secretion of matrix metalloproteinase-2 and -9. Oncogene. 19: 5539-42. 2000 Md. Helal Uddin Biswas, A. R. M. Ruhul Amin, M Anwarul Islam, Choudhury M Hasan, Krik R Gustafson, Michael R Boyd, Lewis K Pannel and Mohammad A Rashid. Monocillinols A and B, novel fungal metabolites from a Monocillium sp. Tetrahedron Letters. 41: 7177-80. 2000 A. R. M. Ruhul Amin, Abdul Jabbar and M. A. Rashid. Antibacterial and cytotoxic activities of the metabolites isolated from a Penicillium strain. Pakistan Journal of Biological Sciences. 6:1365-1367. 2003. M Helal Uddin Biswas, A. R. M. Ruhul Amin, Md. Shah Alam Bhuiyan, M. A. Rashid, Maruf Ahmed and Md. Anwarul Islam. In vitro antibacterial screening of the metabolite of a Monocillium species isolated from a soil sample of Bangladesh. The Sciences. 1: 25-27. 2001. M H Biswas, M A Islam and A. R. M. Ruhul Amin. Brine shrimp lethality bioassay of the metabolites of a Monocillium species. Journal of Bio-Science. 6:129-32. 1998. A. R. M. Ruhul Amin and A Jabbar. Toxicological studies of two antibacterial metabolites isolated from a Penicillium strain on Long Evans rats. Journal of BioScience. 5:229-34. 1997. M A Islam, P Khondhkar, A. R. M. R. Amin and M M Rahman. Sub-acute toxicity of an antimicrobial metabolite isolated from a Monocillium species on Long Evans rats. Journal of Bio-Science. 5:277-84. 1997.

Manuscript Submitted/ In preparation Vijay S Thakur, A. R. M. Ruhul Amin, Rajib K Paul, Sangeet K Agarwal, Kedar Hastak, Mark W Jackson, Hasan Mukhtar and Munna L Agarwal. p53-dependent expression of p21 pre-empts and protects cells from p53-dependent PUMAmediated apoptosis by EGCG. In preparation to submit to JBC. 2. Rajib K Paul, Vijay S Thakur, A. R. M. Ruhul Amin, Sangeet K Agarwal and Munna L Agarwal. p53-dependent PUMA-mediated ROS Leads to Apoptosis of Colon Cancer Cells by Falvonoid, Luteolin. Submitted to PNAS. 3. A. R. M. Ruhul Amin, Vijay S Thakur, Rajib K Paul, Mark W Jackson, Hisashi Harada and Munna L Agarwal. P53-dependent suppression of FOXO1a-Bim
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signaling protects cells from Concanavalin A-induced apoptosis. In preparation to submit to EMBO Journal. 4. A. R. M. Ruhul Amin, Vijay S Thakur and Munna L Agarwal. Opposing roles for p53 and p73 in the regulation of Bim-mediated apoptosis and induction by PALA. In prepation to submit to PNAS 5. Md. Helal Uddin Biswas, Toshinori Hyodo, Pengyu Huang, A. R. M. Ruhul Amin, Hitoki Hasegawa, M Aminur Rahman, Satoko Ito, Takeshi Senga and Michinari Hamaguchi. SHP-2 in v-src-Transformed Cells and Human Breast Tumor Cells: Its Role in Production and Activation of MMP-2. In Preparation to submit to Molecular Biology of the Cell.

ABSTRACT PRESENTED IN CONFERENCES

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Dong M. Shin, A.R.M. Ruhul Amin, Xin Zhang, Zhou (Georgia) Chen, and Fadlo R. Khuri. Effective combination of Green Tea EGCG and EGFR-TKI erlotinib for chemoprevention and therapy in head and neck cancer. 20th EORTC-NCI-AACR symposium on "Molecular Targets and Cancer Therapeutics" held in Geneva from 2124 October, 2008. A. R. M. R. Amin, Xin Zhang, Fadlo R. Khuri. Zhuo (Georgia) Chen and Dong M. Shin. Inhibition of Erlotinib-induced checkpoint but not apoptotic targets by EGCG: Implication for their anti-tumor synergism in squamous cell carcinoma of the head and neck. 99th Annual Meeting, American Association for Cancer Research. San Diego, CA A. R. M. Ruhul Amin, Vijay S Thakur, Dong Moon Shin and Munna L Agarwal. Opposing roles for p53 and p73 in the regulation of Bim-mediated apoptosis induced by PALA. WCI 5th Annual Scientific Research Symposium A. R. M. Ruhul Amin, Vijay S Thakur, Rajib K Paul, Gen S Feng, Hasan Mukhtar and Munna L Agarwal. SHP2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG. 98th Annual Meeting, American Association of Cancer Research. April 14-18, 2007. Los Angeles, CA. A. R. M. Ruhul Amin and Munna L Agarwal. Opposing roles for p53 and p73 in the regulation of Akt-Foxo1a-Bim signaling and apoptosis. 98th Annual Meeting, American Association of Cancer Research. April 14-18, 2007. Los Angeles, CA. Kedar Hastak, Rajib K Paul, Vijay S Thakur, A. R. M. Ruhul Amin, Sudesh Agarwal, Mark W Jackson, George R Stark and Munna L Agarwal. Continued DNA synthesis under imbalanced nucleotide pools leads to DNA damage and ATR/Chk1-dependent phosphorylation and activation of p53. 98th Annual Meeting, American Association of Cancer Research. April 14-18, 2007. Los Angeles, CA. Vijay S Thakur, A. R. M. Ruhul Amin, Rajib K Paul and Munna L Agarwal. p21mediated cell cycle arrest predominates and protects colon cancer cells from p53dependent apoptosis by EGCG. 98th Annual Meeting, American Association of Cancer Research. April 14-18, 2007. Los Angeles, CA.

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Rajib K Paul, A. R. M. Ruhul Amin, Vijay S Thakur and Munna L Agarwal. p53dependent generation of reactive oxygen species mediates apoptosis by Luteolin. 98th Annual Meeting, American Association of Cancer Research. April 14-18, 2007. Los Angeles, CA. A. R. M. Ruhul Amin and Munna L Agarwal. p53-dependent activation of Akt signaling in differential cellular growth by Concanavalin A. 97th Annual Meeting, American Association of Cancer Research. April 1-5, 2006. Washington D. C. A. R. M. Ruhul Amin, Hasan Mukhtar and Munna L Agarwal. Identification of tyrosine phosphatase SHP-2 as a negative regulator of p53-independent apoptosis and p53-target gene expression. 97th Annual Meeting, American Association of Cancer Research. April 1-5, 2006. Washington D. C. A. R. M. Ruhul Amin and Munna L Agarwal. Novel cross-talk between p73 and AktFOXO1a signaling in apoptosis. 2nd Annual Case School of Medicine New Faculty Symposium. April 21, 2006 Kedar Hastak, A. R. M. Ruhul Amin, Mukesh K Agarwal, Hasan Mukhtar and Munna L Agarawal. P53 signaling in negative regulation of cellular growth by green tea. 8th International Conference on Nutrition and Cancer, March 10-12, 2005, Honolulu, Hawai. A. R. M. Ruhul Amin and Michinari Hamaguchi. Secretion of MMP-9 by the proinflammatory cytokine IL-1: a role for SHPS-1-dependent activation of Akt and Erk signalings. 8th World Congress on Advances in Oncology and 6th International Symposium in Molecular Medicine. October 16-18, 2003. Crete, Greece A. R. M. Ruhul Amin. SHP-2 regulates Concanavalin A-dependent secretion and activation of MMP-9 by the Erk and p38 pathways. The 6th Membrane Research Forum and the 13th ATI International Forum. November 4-7, Nagoya, Japan. A. R. M. Ruhul Amin and Michinari Hamaguchi. A role for SHPS-1-SHP-2 complex formation in IL-1 and TNF signalings. 61st Annual Meeting of the Japanese Cancer Association. October 1-3, 2002. Tokyo, Japan A. R. M. Ruhul amin, Kazuya Machida, Kumi Oshima and Michinari Hamaguchi. Role of SHPS-1-SHP-2-PLC-complex formation in IL-1-dependent MAP kinase activation and cell proliferation. 17th Annual Meeting on Oncogenes. June 20-23, 2001. Hood College, Frederick, Maryland, USA. A. R. M. Ruhul Amin, Kazuya Machida, Takeshi Senga, Aye Aye Thant, Satoru Matsuda and Michinari Hamaguchi. IL-1-mediated activation of PI (3) kinase-Akt pathway. 73rd Annual Meeting of Japanese Biochemical Society. October 11-14, 2000. Yokohama, Japan.

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REFERENCES Dr. Dong Moon Shin Professor and Executive Vice Chair, Francis and Earl Blomeyer Chair in Cancer Research Director, Head and Neck Cancer SPORE Director, Cancer Prevention Program Co-Director, Discovery and Developmental Therapeutics Program Co-Director, Lung and Aerodigestive Malignancies Program

Associate Director of Academic Development Department of Hematology and Medical Oncology Winship Cancer Institute Atlanta, GA, 30329 e-mail:dmshin@emory.edu Phone: 404-778-2980
2. George R Stark Distinguished Scientist, Department of Molecular Biology, Cleveland Clinic Foundation and Professor, Department of Genetics, Case Western Reserve University E.mail: starkg@ccf.org Phone: (216) 444-6062 Fax: (216) 444-0512

3. Fadlo R Khuri Professor and Chair Department of Hematology and Medical Oncology Winship Cancer Institute Atlanta, GA, 30329 e-mail:fkhuri@emory.edu 4. Prof. Michinari Hamaguchi Dean Nagoya University School of Medicine Nagoya 466-8550, Japan Phone: 81-52-744-2462; Fax: 81-52-744-2464; Email: mhamagu@med.nagoya-u.ac.jp