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Victoria A.

Newton
SPIRE Postdoctoral Fellow, Department of Medicine 111 Mason Farm Road, CB# 7545 University of North Carolina at Chapel Hill Tel: (919) 966-2284 Email: Victoria_Newton@med.unc.edu

Education:

Ph.D. in Cell and Molecular Physiology University of North Carolina at Chapel Hill School of Medicine Department of Cell and Molecular Physiology 2004-2010 Bachelor of Science in Applied Biology Track: Molecular Biology and Genetics Honors graduate Georgia Institute of Technology Department of Biology Overall GPA: 3.21

Professional Experience:
Sept 2010 Present Postdoctoral FellowDr. Scott T. Magness Investigated the role of crypt-based enteroendocrine cells in the proliferation, selfrenewal, and differentiation of intestinal epithelial stem cells and evaluated whether Sox9 in these cells controls downstream target genes that influence intestinal epithelial stem cells using an inducible conditional Sox9-knockout mice and Fluorescent Activated Cell Sorting to isolate intestinal cell types. Novel in vitro crypt organoid culture systems were used to investigate the effects of crypt-based enteroendocrine cells on isolated intestinal epithelial stem cells. Graduate Research AssistantDr. P. Kay Lund Modulation of insulin-like growth factor receptor (IGF-IR) signaling by suppressor of cytokine signaling-2 (SOCS2) and epidermal growth factor receptor (EGFR) in intestinal tumor development Investigated mechanisms through which Suppressor of Cytokine Signaling 2 (SOCS2) limits tumorigenesis using the Apc(Min/+) mouse model of spontaneous small intestine and colon cancer. I determined that loss of SOCS2 in these mice promotes dramatic increases in tumor load in the small intestine and colon and increases tumor incidence in the colon. These increases correlated to an increase in STAT3 serine phosphorylation and activation of the transcription factor AP-1. This work is published in the American Journal of Pathology in 2010. I also examined the mechanisms of IGF-I and EGF interactions in normal intestinal epithelial cells and in tumorigenesis both in vivo and in vitro. Our in vitro work showed that treatment with both IGF and EGF produced synergistic increase in proliferation through a PI-3K- and MAPK-driven mechanism. In vivo, I examined whether a loss of both IGF-IR and EGFR signaling resulted in greater protection against tumor development in Apc(Min/+) mice. I found that combined loss of these receptors dramatically reduced tumor load in the colon of female mice, but did not affect male mice, suggesting gender-specific effects of these pathways in colon cancer.

June 2005 Aug 2010

Published Articles
1. Newton VA, Ramocki NM, Scull BP, Simmons JG, McNaughton K, and Lund PK. Suppressor of cytokine signaling-2 gene disruption promotes ApcMin/+ tumorigenesis and AP-1 activation. Am. J. Path. Accepted Jan 19, 2010

2. Murph MM, Hurst-Kennedy J, Newton V, Brindley DN, Radhakrishna H. Lysophosphatidic acid decreases the nuclear localization and cellular abundance of the p53 tumor suppressor in A549 lung carcinoma cells. Mol Cancer Res. 2007 Nov;5(11):1201-11.

Research Experience
May 2003 Aug 2003 Howard Hughes InternDr. Harish Radhakrishna Department of Biology, Georgia Tech Investigated signaling mechanisms of lysophosphatidic acid downregulation of p53 in hepatocellular and lung carcinoma cell lines. (LPA)-mediated

May 2002 July 2004

Undergraduate Research AssistantDr. Harish Radhakrishna Department of Biology, Georgia Tech Used RT-PCR to determine the expression of lysophosphatidic acid receptors in existing cancerous cell lines commonly used in the lab. Participated in research that investigated the clathrin and non-clathrin mediated endocytosis of the muscarinic2 receptor.

References
1. Scott T. Magness, Ph.D. Assistant Professor of Medicine University of North Carolina at Chapel Hill 111 Mason Farm Road Chapel Hill, NC 27599-7545 Email: scott_magness@med.unc.edu Phone: (919) 966-6816 3. Brian Rybarczyk, Ph.D. Coordinator, SPIRE Postdoctoral Fellowship Program Lecturer, Department of Biology The University of North Carolina at Chapel Hill Graduate Student Center, 211A West Cameron Ave. Chapel Hill, NC 27599-5492 Email: brybar@unc.edu Phone: (919) 962.2505 2. Dr. Timothy Champion Chair of the Department of Natural Sciences and Mathematics Professor of Chemistry Johnson C. Smith University 100 Beatties Ford Road Charlotte, NC 28216 Email: tchampion@jcsu.edu Phone: (704) 378-1155 4. P. Kay Lund, Ph.D. Sarah Graham Kenan Professor in Cell and Molecular Physiology. Professor in Pediatrics and Nutrition. Editor-in-Chief, American Journal of Physiology, GI and Liver University of North Carolina at Chapel Hill 111 Mason Farm Road Chapel Hill, NC 27599-7545 Email: empk@med.unc.edu Phone: 919-966-0697

Honors and Awards


Sep 2009 Nov 2007 Sep 2006 July 2006 Aug 2003 Dec 2003 May 2003 Fall 2000 Fall 2003 Poster Prize, Departmental Research Day, Department of Cell and Molecular Physiology, UNC Chapel Hill American Association of Cancer Research (AACR). AFLAC, Inc, Scholar-In-Training Award for poster abstract. st Center for Gastrointestinal Biology and Disease Research Competition, 1 place and received travel award Received High Pass on Qualifying Exams Burroughs Wellcome scholarship and UNC Departmental Assistantship and scholarship Honors Graduate from Georgia Tech Awarded Howard Hughes Internship for summer of 2003 Deans List

Teaching Experience
Fall 2012 Spring 2012 Primary lecture and laboratory instructor. Cell Biology, Department of Natural Sciences. Johnson C. Smith University. Designed and developed syllabus, lectures and laboratory for sophmorelevel undergraduate cell biology course. Course is required for Biology majors and is a prerequisite for upper-level biology courses, such as genetics. Lecture materials focused on molecular cell physiology, combining basic lecture that stressed active learning, with problem and research-based case studies and assignments. Investigative laboratories emphasized the scientific method and basic laboratory skills. Graduate Endocrine and Gastrointestinal Physiology, Department of Cell and Molecular Physiology. Assisted in 5 sessions and cotaught 1. Guest lecture, Female Reproduction, Anatomy and Physiology. North Carolina Agriculture and Technology State University. Prepared lecture material and presentation for class. Taught material pertaining to anatomy and physiology of the female reproductive system to biology and nursing students. Prepared questions for students to answer about material. Assisted in workshops for Homeschool students at Center for Excellence and Learning. Set up labs and assisted students with planned exercises. Student ranged from 6 12 years of age. Teaching Assistant for lab in Anatomy and Physiology. UNC Chapel Hill. Headed one lab section of 25 students. Prepared short introductory lectures. Assisted students with identifying structures and led physiological demonstrations. Graded assignments, quizzes and exams for the lab section, and for the corresponding class and kept detailed records. Gastrointestinal physiology review session for Nursing Students. Fundamentals of Anatomy and Physiology. Assistant TA in charge of the gastrointestinal physiology section of the class. Available to students to answer questions about the lecture material. Conducted a review session on the material DNA Day, UNC Chapel Hill, NC. Taught modules to high school students about pharmacogenomics and cystic fibrosis in order to relate the human genome to disease and medicine. Techwood Tutorial Project, Atlanta, Georgia tutored children in grades K-2 at C.W. elementary school for 1 hour each week. Subjects varied and activities were guided by the teacher.

Jan 2010 Nov 2009

Oct 2009 Sept 2009 April 2009 Jan 2009May 2009

March 2008

April 2011 April 2009 April 2008 April 2007 Aug 2002 Dec 2003

Teaching Workshops
Sept 2011 Nov 2011 Dec 2010 Sep 2009 June 2008 July 2007 July 2007 College Teaching Ed Neal, Ph.D. SPIRE Postdoctoral program seminar on college teaching. SPIRE Postdoctoral Program, UNC Chapel Hill, NC Effective College Teaching Richard Felder, Ph.D. and Rebecca Brent, Ed.D. Office of Postdoctoral Affairs and SPIRE Postdoctoral Program, UNC Chapel Hill, NC Integrating Homework and Textbook Reading and Class Donna Bailey and Todd Zakrasjek, Center for Faculty Excellence, UNC Chapel Hill, NC Using Investigative Cases Inquiry based Learning Margaret Waterman and Ethel Stanley, BioQUEST Curriculum Consortium. UNC Chapel Hill, NC Lunch n Learn Series: Teaching Your First Undergraduate Biology CourseA panel discussion with SPIRE fellows. UNC Chapel Hill, NC Designing a Course Ed Neal, Sponsored by Training Initiative in Biomedical and Biological Sciences (TIBBS), the Center for Teaching and Learning and the Office of Postdoctoral Services. UNC Chapel Hill, NC Learning Techniques with Patricia Pukila Patricia Pukila. Practical Application of learning techniques with Patricia Pukila Patricia Pukila. Sponsored by Training Initiative in Biomedical and Biological Sciences (TIBBS), the Center for Teaching and Learning and the Office of Postdoctoral Services.

June 2007

Mentorees/Trainees
Sep 2011 May 2012 Nan Lin. Undergraduate Assistant. Training in histology techniques, such as immunohistochemistry and cryo-sectioning. With guidance and training by Xiao, both students contributed significantly to post-doctoral work by investigating the number of long-lived enteroendocrine cells in the small intestine Xiao Fu Liu. Undergraduate HHMI-FSC Scholar and undergraduate assistant. Comentor for HHMI-FSC internship. Trained in immunohistochemistry, microscopy, tissue preparation, data-analysis and record keeping. Mentored on overall poster presentation for HHMI-FSC scholars at end of summer internship. Gieria Jones. Graduate student. Trained in methods for microarray such as tissue harvest, RNA isolation and quality assessment; guided in experimentation, design, and interpretation. Lisa McCoig. Rotation student. Trained in histological scoring of cellular proliferation, tumor burden, and mouse husbandry and colony management. Adrienne Krebs. Undergraduate assistant. Trained in genotyping protocols, including isolation of tail DNA and PCR genotyping reactions. Read and critique honors thesis. Leah Watson. Rotation student. Trained in RNA isolation, cDNA preparation and SYBR green real-time PCR. Assisted in analysis of results. Instructed in basic lab protocols and record keeping. Mentored on overall poster presentation.

May 2011 present

June 2009 Oct 2009 Jan 2009 April 2009 Aug 2008 Aug 2007 Nov 2007

Invited Seminars and Oral Presentations


Mar 2012

A tale of two stem cells: are Sox9EGFP cells another stem cell population in the intestine Johnson C. Smith University. Junior/Senior Seminar class. Charlotte, NC Crypt-based enteroendocrine cells and their effect on the intestinal stem cell niche Fayetteville State University, Fayetteville, NC Crypt-based enteroendocrine cells and their effect on the intestinal stem cell niche North Carolina Central University, Durham, NC Crypt-based enteroendocrine cells and their effect on the intestinal stem cell niche Johnson C. Smith University, Charlotte, NC Crypt-based enteroendocrine cells and their effect on the intestinal stem cell niche North Carolina Agricultural and Technical State University, Greensboro, NC Crypt-based enteroendocrine cells and their effect on the intestinal stem cell niche University of North Carolina - Pembroke, Pembroke, NC IGF-I and EGF promote synergistic increases in proliferation, enhanced IGF-IR activation, and increased nuclear -catenin in intestinal epithelial cells. Experimental Biology, New Orleans, LA SOCS2 is a Tumor Suppressor is spontaneous intestinal tumorigenesis Biomedical and Biological Sciences Program, Recruiting weekend 20 minute talk given to prospective students. Commensal Microflora and Responses to Fasting and Refeeding st CGIBD Presentation Contest1 place.
HI

HI

Mar 2011 Feb 2011 Feb 2011 Feb 2011 Jan 2011 April 2009

Feb 2008

Sep 2006

Posters Presentations
July 2012

Sox9EGFP cells exhibit characteristics of quiescent stem cells in the intestine of adult and neonatal mice. Victoria A. Newton, Adam D. Gracz, Xiao Fu Liu, Nan Lin, Chris Givens, Michael J. Cronce and Scott T. Magness CGIBD Scientific Retreat and Poster Competition, UNC Chapel Hill, NC Crypt-based enteroendocrine cells and their effect on the intestinal stem cell niche. Victoria A. Newton, Adam D. Gracz, Xiao Fu Liu, Michael J. Cronce, Brooks P. Scull, and Scott T. Magness CGIBD Scientific Retreat and Poster Competition, UNC Chapel Hill, NC Crypt-based enteroendocrine cells and their effect on the intestinal stem cell niche. Victoria A. Newton, Adam D. Gracz, Xiao Fu Liu, Michael J. Cronce, Brooks P. Scull, and Scott T. Magness IRACDA Annual Conference, Houston, TX Loss of Suppressor of Cytokine Signaling-2 (SOCS2) Promotes Tumor Development Min/+ during GH Excess and in Apc mice Newton V, Ramocki NM, Scull BP, Lund PK AACR Special Conference, Advances in Colon Cancer Research Scholar-In-Training Award-poster presentation LPA activation of Edg2 inhibits expression of p53 Newton V, Murph M, Radhakrishna H. Poster Presentation Howard Hughes Internship Research Symposium

June 2011

June 2011

Nov 2007

Aug 2003

Service Contributions/Positions Held


Sep 2012 Sep 2012 Mar 2012 May 2011 Secondary reader, Student Investigative Senior Paper for Halimah Ali-Stratton. Johnson C. Smith University, Charlotte, NC. Secondary reader, Student Investigative Senior Paper for Keanna Murray. Johnson C. Smith University, Charlotte, NC. Reviewer. American Journal of Physiology Gastrointestinal and Liver Physiology Panel Member. How to have a successful summer experience. Joint Panel Discussion for undergraduates participating in the SPIRE summer research program and PMABS summer research program. Reviewer. American Journal of Physiology Gastrointestinal and Liver Physiology Graduate student Representative, member of the Graduate Committee in the Department of Cell and Molecular Physiology. Provided input to the graduate committee faculty on all issues concerning graduate students in the department and offered consensus student viewpoint on decisions affecting the department. Was responsible for planning, recruiting volunteers, and executing recruitment weekends for prospective students including making reservations, transportation, and weekend activities. I also assisted the Committee in planning and execution of external departmental review, including gathering student input and designing and implementing questionnaires.

Nov 2010 Aug 2007 Aug 2009

Conferences attended
June 2012 June 2011 April 2009 Nov 2007 Nov 2003 Nov 2002 Association of Biological Laboratory Educators (ABLE). UNC Chapel Hill, NC IRACDA (Institutional Research and Academic Career Development Awards) Conference. Houston, TX. Experimental Biology, New Orleans LA Association for Advancement of Cancer Research (AACR) Special Conferences Advances in Colon Cancer Research, Cambridge, MA. Georgia Cancer Coalition Symposium, Atlanta, GA Georgia Cancer Coalition Symposium, Athens, GA

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