KETOBEMIDONE 1-[4-(3-hydroxyphenyl)-1-methyl-4-piperidyl]-1-propanone 4-(m-hydroxyphenyl)-1-methyl-4-piperidyl ethyl ketone synonyms & commercial names (of HCl salt): Hoechst 10720, Win

1539, Cliradon, Cy midon, Ketogan, Ketogin C15H21NO2 MW: 247.33 g/mol Preparation: Suter, "Abstracts of the First National Medicinal Chemistry Symposium of the A.C .S." (Ann Arbor, 1948), p 20 British Patent # 591992 (1947, Ciba) British Patent # 609763 (1948, Ciba) Eisleb, US Patent # 2167351 (1939, Winthrop) Eisleb, US Patent # 2242575 (date = either 1939 or 1941, Winthrop) Eisleb, US Patent # 2248018 (1941, Winthrop) Eisleb, German Patent # 752755 (1952 to I.G. Farben) Metabolism (in humans): U. Bondesson et al. -- Drug Metab Dispos, 1981, v 9, p 376 Crystals mp 156 - 157 C [hydrochloride salt] C15H22ClNO2 Crystals mp 201 - 202 C Soluble in water slightly soluble in alcohol Aqueous solutions may be sterilized by boiling for short periods ----------> (aq solns of Amidone may also be autoclaved for up to an hour w/o any loss in po tency)