PATHOLOGY

1. All of the following are concluded as Gestational trophoblastic diseases, EXCEPT ? A. B. C. D. Hydatiform mole Choriocarcinoma Invasive ductal carcinoma Invasive mole

2. Which of the following statements is FALSE regarding complete vesicular mole? A. B. C. D. Its karyotype is 46XX/XY. Hydropic swelling is found in almost all villi. It does permit embryogenesis and contains fetal part. There is marked elevation of serum HCG.

3. Which of the following statements is FALSE regarding partial vesicular mole? A. B. C. D. Its karyotype is 69XXY. The fetal part is present. Caused by fertilization of an empty ovum by two sperms. There is some increase of serum HCG.

4. Choose the CORRECT statement(s) regarding microscopic picture of partial vesicular mole. i. ii. iii. A. B. C. D. Villous edema is found only in some villi. The villi vascularization is absence. Trophoblastic proliferation is focal and slight. i only i & ii ii & iii i & iii

5. Choose the FALSE statement regarding Choriocarcinoma: A. B. C. D. an aggressive malignant tumor Most cases occur before the age of 20 years and above the age of 40 years old There is formation of chorionic villi microscopically Grossly the uterus is filled with a large soft, fleshy mass.

6. - Cystic dilatation of breast ducts during lactation. - Obstruction of breast ducts by inflammation and fibrosis with accumulation of milk. - During acute phase, it is tender and if opened it will show collection of milky fluid. Later on, contents will become inspissated and cheesy. It may rupture causing local inflammatory reaction. Which of the following have the above characteristics: A. B. C. D. Acute mastitis and breast abscess Chronic mastitis Fat necrosis Galactocele

7. All of the following describing the characteristics of non- proliferative fibrocystic changes, EXCEPT? A. B. C. D. Fibrosis Adenosis Cyst formation Epithelial Hyperplasia

8. Which of the following diseases or lesions show apocrine metaplasia ? A. B. C. D. Non proliferative fibrocystic changes Epithelial hyperplasia Sclerosing adenosis Proliferative fibrocystic diseases.

9. Which of the following diseases or lesions has the highest risk of developing breast cancer? A. B. C. D. Non proliferative fibro cystic changes Proliferative fibrocystic diseases. Proliferative fibrocystic disease with atypia. Proliferative fibrocystic disease with atypia and with positive family history.

10. Which of the below is not related to Fibroadenoma? A. B. C. D. Encapsulated Caused bloody nipple discharge Related to estrogen hormone Occur in female below 30 years

11. Which will decrease the risk of breast cancer? A. B. C. D. Prolonged exposure to endogenous and exogenous estrogen Endometrial carcinoma Nullipara Prolonged breast feeding

12. Which tumor developed from lactiferous duct? A. B. C. D. Phyllodes tumor Fibroadenoma Lobular carcinoma Duct papilloma

13. Most common type of breast cancer is A. B. C. D. Colloid carcinoma Fibroadenoma Invasive ductal carcinoma of NOS Phyllodes tumor

14. All the statements below are correct EXCEPT A. B. C. D. Comedo ductal carcinoma in situ characterized by having central necrosis main neoplastic component of Fibroadenoma is the epithelial element Phyllodes tumor does not arise from pre-existing Fibroadenomas 20% of breast carcinoma arise from central area of the breast

15. Which is most common type of infiltrating duct carcinoma? A. B. C. D. Intraductal papilloma Invasive lobular carcinoma Paget's disease Invasive Ductal Carcinoma of no special type

16. Which carcinoma that has tumor cell floating in large lake mucin as microscopic picture? A. B. C. D. Colloid carcinoma Comedo ductal carcinoma Cribiform duct carcinoma Medullary carcinoma

17. Which of these usually mistaken for eczema? A. B. C. D. IDC Fibroadenoma Acute Mastitis Paget's disease

18. Why it is important to differentiate between lobular and ductal carcinoma? A. B. C. D. Different treatment Lobular has higher tendency to be multifocal and bilateral Lobular produced palpable mass but ductal produce non palpable mass For medicolegal report

19. Which state?

Tumor size : <2cm Lymph Node : Axillary Metastasis : Present

A. B. C. D.

Stage 1 Stage 2 Stage 3 Stage 4

20. Which most important prognostic factor? A B. C. D. .Histologic type Present oestrogen and progesterone receptor Angiogenesis Tumor size

21. All can cause nipple discharge except.. A. B. C. D. Duct papilloma Paget disease Proliferative fibrocystic change with epithelial hyperplasia Fibroadenoma

22. All are true about gynecomastia except.. A. B. C. D. usually bilateral may occur at puberty due to hormonal imbalance analogue of fibroadenoma in female breast occur at old age mostly due to liver disease

23. Why carcinoma in male invasive rapidly to overlying skin and thoracic wall A. B. C. D. synergistic effect with testosterone high metabolic state than female scant amount of breast substance resemble invasive carcinoma in female

Histology

24. Regarding lactating mammary glands, all the following are true, EXCEPT? A. B. C. D. First grade alveoli consist of high pyramidal cells Milk production is done inside the columnar epithelial cells of secretory portion Alveoli are surrounded by spindle shaped myoepithelial cells Alveoli in one lobule demonstrate the same state of activity, but functionally different from neighboring lobules

25. The colostrum contains A. B. C. D. High calcium and high phosphate High protein and high fat High calcium and low carbohydrate High protein and low fat

26. Regarding mammary glands of pregnant female, the secretory alveoli are compound tubule-alveolar glands of what type? A. B. C. D. Merocrine Apocrine Sebaceous Halocrine

27. Regarding resting mammary glands, which one of the following is FALSE? A. B. C. D. Are a pair of compound tubule-alveolar glands covered by thin skin Nipple consists of dense connective tissue and smooth muscle fibers Lactiferous sinus is a modified type of sebaceous glands Tip of nipple is richly supplied by free nerve endings

28. Lobulation of mammary glands is obvious during what stage of its development? A. B. C. D. Second half of pregnancy Few days after delivery Last three months of pregnancy After menopause

29. All are false about testis except A. B. C. D. secondary sex organ covered by tunica vasculosa,processus vaginalis and tunica albuginea functioning as exocrine gland to produce testosterone can produce spermatozoa

30. which tunica is thickened to form mediastinum? A. B. C. D. tunica vasculosa tunica albuginea tunica vaginalis tunica reticularis

31. which of this is structural and functional unit of testes A. B. C. D. Leydig cell Epididymis Seminiferous tubule Vas deferens

32. Tunica propria or fibrous coat that surround semineferous tubule form of? A. B. C. D. myoepithelial and leydig cell sertoli cell and macrophage capillary and spermatid fibroblast and myoid cell

33. Which part is called tunica vasculosa or testicular interstitium? A. B. C. D. In the seminiferous tubule Between the seminiferous tubule Embended in serous sac Between the tunica vaginalis and tunica albuginea

34. All are true about sertoli cell except... A. B. C. D. Pale nucleus with tripartite nucleolus proliferate by mitosis to form another sertolli cell tall cell from basement membrane to lumen of seminiferous tubule LM cytoplasm is pale due to excess lipid droplet

35. Which of this attach to the apex of sertolli cell? A. B. C. D. Secondary spermatocyte Spermatocyte Spermatogonia Spermatid

36. Which of this structure in sertolli cell contribute in change of cell shape? A. B. C. D. centriole microtubule protein transport ribosome

37. all are true about blood testicular barrier except... A. B. C. D. it divide into two compartment, basal and adluminal show tight junction between adjacent sertoli cell adluminal compartment contain spermatid, primary spermatocyte and spermatogonia prevent the occurence of autoimmune disease

38. Which of these following are FALSE about spermiogenesis? A. B. C. D. spermatids undergo cytological changes to be spermatozoa all change occur while spermatids are embedded into the luminal surface of Sertoli. undergo successive mitotic & meiotic divisions to be changed into spermatids all changes in the spermatids will be involve change in Golgi body,centrioles, mitochondria & nucleus

39. What is the function of Manchette ? A. B. C. D. digest corona radiata & zona pellucida that surround ovulated eggs after fertilization push cytoplasm to place posteriorly motility of the sperm phagocytosis of the dead spermatids

40. Where is the site for interstitial cells of Leydig ? A. B. C. D. In tunica vasculosa in between seminiferous tubules In visceral part of tunica vaginalis In between spermatogenic cells In tunica Albuginea

41. What are the causes of Acidophilic in Leydig cells? A. B. C. D. macrophages & mast cells macrophages & lipid droplet mitochondria & sER mitochondria & rER

42. Which of the following is true about Leydig cells ? A. B. C. D. Its function to secrete progesterone hormone Its nucleus are large,maybe central or eccentric Its shape are small and rounded Its inhibit spermatogenesis

43. All of those following are process in Golgi phase EXCEPT A. B. C. D. Nucleus become condense & elongated proacrosomal granule will fuse together to form acrosomal vesicle one of centriole will be elongated & spinning the axoneme pair of nucleus moves to the caudal pole of the nucleus

ANATOMY 44. Which of the following is false regarding the scrotum? A. B. C. D. It has dark skin fold It superficial layer contain fat but no dartos muscle It arterial supply are inferior epigastric and deep external pudendal Posterior 2/3 supply by posterior cutaneous nerve of the thigh and scrotal branches of the perineal nerves

45. The following are the arterial supply of penis except: A. B. C. D. Dorsal artery of penis Artery of bulb Cremasteric artery Superficial external pudendal artery

46. The followings are false statement of covering of testis except: A. B. C. D. Dark and smooth skin Colles fascia Internal spermatic fascia Cremasteric nerve

47. Choose the false statement regarding the epididymis: A. B. C. D. Head attached to upper end of testis by 12-30 efferent ductules Highly coiled tube,lies on posterior border of the testis Sinus of epididymis is a recess of tunica vaginalis Tail attached to upper end of testis and continue as the vas deferens

48. Which is the correct statement regarding contents of spermatic cord: A. B. C. D. Genital branch of genitofemoral nerve Vein of vas Vestigue of processus vas deferens Parasympathetic fibers

49. Which of the following is false regarding the testis? A. B. C. D. Suspended by epididymis in the scrotum Supplied by testicular artery from abdominal aorta Left testis drains into left renal vein Its lymphatic drainage is para- aortic lymph nodes

50. The covering of testis includes the following except: A. B. C. D. Dartos muscle Tunica vasculosa Tunica vaginalis Cremasteric muscle

51. The following statements regarding epididymis are true except: A. B. C. D. A highly coiled tube lies posterior to the testis Composed of head, body and tail Sinus of epididymis is a recess of tunica albugenia Arterial supply of epididymis are testicular artery and artery of vas

52. Choose the true statement regarding contents of spermatic cord: A. B. C. D. Internal spermatic fascia Ejaculatory duct Seminal vesicle Pampiniform venous plexus

53. The following statement is true regarding coverings of spermatic cord except: A. B. C. D. Internal spermatic fascia derived from fascia transversalis Tunica albugenia which is the serous sac invaginated by testis Cremasteric muscle fascia from internal oblique muscle External spermatic fascia from aponeurosis of external oblique muscle

54. The following statements is true about the prostate EXCEPT? A. B. C. D. The anterior surface is related to pubic bone and puboprostatic ligament. Prostate is conical in shape where the apex is directed upward and base is directed downward. The inferolateral surface is related to levator ani muscle. It is a compound tubuloalveolar exocrine gland of the male reproductive system.

55. The following is the structures inside the prostate EXCEPT? A. B. C. D. Prostatic urethra Ejaculatory ducts Seminal vesicle Prostatic utricle.

56. Which of the following is FALSE regarding function of prostate? A. B. C. D. Prostate fluid is expelled together with urine. Prostate fluid has a pH of 7.29 Prostate contain smooth muscle to help to expel the semen during ejaculation. Secrete prostatic fluid which help in prolonging the life span of the sperm.

57. Which of the following is the arterial supply for seminal vesicle? A. B. C. D. Superior rectal arteries. Medial rectal artery Inferior vesicle Superficial external pudendal artery.

58. Which of the following is true regarding the ejaculatory duct? A. It is formed by the union of the duct of seminal vesicle and terminal part of the vas deferens. B. It is a firm partly glandular and partly muscular C. It passes anteroinferiorly to open into the prostatic utricles. D. It is about 7cm long.

PHYSIOLOGY

59. Hormone below secreted by Sertolli cell exept: A. B. C. D. Inhibin Progesterone Oestrogen Mullerian inhibitory factor

60. Which of the following cell get stimulation from Follicle-stimulating Hormone directly : A. B. C. D. Primary spermatocytes Spermatogonia Sertolli cells Leydig cells

61. How ABP secreted by Sertolli cell important to complete process of spermiogenesis? A. B. C. D. It help in shaping of head and tail of sperm It help to provide special environment for germinal cell develop It help in provide appropriate nutrient for newly formed sperm It will bind to testosterone secreted from Leydig cell

62. Those are the functions of Sertolli except: A. B. C. D. Blood-testis barrier Phagocytosis Supportive and nutrition Secretory

63. Choose the false statement about functions of blood brain barrier : A. Prevent protein & other large molecules to pass from interstitial tissue but allows steroids to pass B. Causing peristaltic contractions in uterus & fallopian tubes to move sperm towards ovum C. Protect germ cells from harmful substance from tunica vasculosa D. Prevent blood from antigenic products of germ cell division & from dead sperm 64. Statement below are false except: A. B. ovum C. D. Life span of sperm in male genital tract is about 1-2days. Sperm removed from seminiferous tubule are completely motile and can fertilize Secretion of prostate gland is slightly alkaline from other secretion Absence of growth hormone has no affect to spermatogenesis

65. Statements below are true except: A. Testosterone stimulate meiotic division of primary spermatocyte to secondary spermatocyte B. Secretion of fibrinogen from seminal vesicle reacts with cervical mucus, make it more receptive to sperm C. Sertolli cell helps in spermiation process by help of digestive enzyme in it D. Muellerian inhibitory factor secreted during fetal life to inhibit fallopian tube formation from Muellerian ducts in male fetus

PHARMACOLOGY

66. Steady dosing of GnRH results in the stimulation of FSH and LH. A. B. True False

67. Citrorelix inhibit the action of GnRH by binding to GnRH receptors on the anterior pituitary. A. B. True False

68. Pituitary gonadotrophic hormones include: I. II III IV A. B. C. D. E. FSH LH Dopamine Prolactin I and II I, II and III II and III I, II and IV All of the above

69. Urofollitropin: A. B. C. D. Synthetic FSH Extracted from the urine of postmenopausal women Extracted from the urine of pregnant women Compounds for regulation of menstrual cycle

70. What are the adverse effects estrogens? I. II. III. IV. A. B. C. D. Thromboembolism Osteoporosis Prostatic cancer Edema I and II I and III I and IV II and III

Answers: 1. C 2. C 3. C 4. D 5. C 6. D 7. D 8. A 9. D 10.B 11.D 12.D 13.C 14.B 15.D 16.A 17.D 18.B 19.D 20.D 21.D 22.C 23.C 24.C 25.D 26.B 27.C 28.B 29.D 30.B 31.C 32.D 33.B 34.B 35.D 36.B 37.C 38.C 39.B 40.A 41.C 42.A 43.A 44.B 45.C 46.C 47.D

63 63 64 65 66 66 68,57 68 68

79 79 79 80 80 87 87 87 88

110 112 113 114

48.A 49.A 50.B 51.C 52.D 53.B 54.B 55.C 56.A 57.C 58.A 59.C 60.C 61.D 62.D 63.B 64.C 65.B 66.B 67.A 68.D 69.B 70.C

115 112 113 114 115 115 117 117 116 117