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Meninges
-are three connective tissue membranes that invest the spinal cord and brain.
-consist of the pia mater and the arachnoid (together known as the leptomeninges)
and the dura mater (pachymeninx).
A. Pia mater
1. Denticulate ligaments
-consist of two lateral flattened bands of pial tissue.
-attach to the spinal dura mater with 21 teeth.
2. Filum terminale
-consists of a nonneural band of tissue that is a condensation of the pia
mater.
-extends from the conus medullaris to the end ofthe dural sac and fuses
with it.
Lower part of spinal cord showing filum terminale and dura
B. Arachnoid
-is a delicate. Nonvascular connective tissue membrane located between the dura
mater and the pia mater.
-enter the venous dural sinuses and permit the one-way flow of cerebrospinal
fluid (CSF) from the subarachnoid space into the venous circulation.
-are found in large numbers along the superior sagittal sinus but are associated
with all dural sinuses.
2. Subarachnoid space
-is located between the pia mater and the arachnoid.
-contains CSF.
-surrounds the entire brain and spinal cord.
-extends, in the adult, below the conus medullaris to the level ofthe second
sacral vertebra, the lumbar cistern
c. Dura mater
-is the outer layer of the meninges and consists of dense connective tissue.
-The supratentorial dura is innervated by the trigeminal nerve; the posterior fossa is
innervated by the vagal and upper spinal nerves.
-forms three major reflections and the walls of the dural venous sinuses:
1. Falx cerebri
2. Tentorium cerebelli
-separates the posterior cranial fossa from the middle cranial fossa.
-separates the temporal and occipital lobes from the cerebellum and
infratentorial brainstem.
-contains the tentorial incisure, or notch, through which the brainstem passes.
3. Diaphragma sellae
4. Dural sinuses
-are endothelium-lined, valveless venous blood channels.
D. Meningeal spaces
1. Spinal epidural space
-is located between the dura and the vertebral periosteum.
-contains loose areolar tissue, venous plexuses, and lymphatics.
-may be injected with a local anesthetic to produce a paravertebral nerve
block.
-is a potential space between the periosteal and meningeal layers of the dura.
-contains the meningeal arteries and veins.
3. Subdural space
4. Subarachnoid space
5. Subarachnoid cisterns
-are dilations of the subarachnoid space, which contains CSF.
-are named after the structures over which they lie (e.g., pontine, chiasmatic,
and interpeduncular cisterns).
Ventricles
-are lined with ependyma and contain CSF.
-contain choroid plexus, which produces CSF at a rate of 500 ml/day.
- consist of four fluid filled communicating cavities within the brain
A. Lateral ventricles
- Are the two ventricles located within the cerebral hemispheres
-communicate with the third ventricle via the interventricular foramina of Monro.
-consist of five parts:
2. Body
-is located in the medial portion of the frontal and parietal lobes.
-has choroid plexus.
-communicates via the interventricular foramen of Monro with the third
ventricle.
5. Trigone (atrium)
-is found at the junction of the body, occipital horn, and temporal horn of the
lateral ventncIe.
Clinical Importance
• Excessive accumulation of CSF in skull along with enlargement of head
is known as hydrocephalous
Blood-Brain Barrier
Remember- BBB is easily permeable for H2O, CO2, O2 and lipid soluble
substances.
Not well developed in infants- bile pigments which normally do not cross
BBB are able to pass through BBB in infants.
Certain areas of brain are devoid of BBB:
• Pituitary – helps in carrying hormones from pituitary to target organs via
blood
• Subfornical organs
• Pineal region
• Supra-optic area
• Median eminence
• Choroid plexus