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Number of patients per indication Israel Medical Cannabis Program November 2011
indications pain cancer Multiple sclerosis Neurological disorders Various diseases Psychiatry (mostly war-related PTSD) Parkinson Gastro ALS
DIABETES
Cannabis consists of the dried flowers of the female Cannabis sativa L plant, also known as hemp or marihuana. Cannabis contains a number of active substances, like THC and Cannabidiol (CBD) THC is mainly responsible for the effects of cannabis, but others like CBD may also influence the effectiveness of the drug. The chemical composition of the cannabis determines the effects and side effects. Cannabis dispensed by pharmacies complies with the strictest quality standards and is intended for medicinal use only. Therefore, it is called medicinal cannabis.
Disadvantages
No protection from the weather or diseases of the plants, no standardization, no control over flowering and light Substantial investment required, If money available use heating and cooling equipment and energy is expensive.
Remarks
Only few MC growers, mostly in California, grow outside
Greenhouses
Indoors
Very Hi initial investment + Industrial rent + on going climate control expenditure on energy. Possible leakage, hi initial investment, requires sophisticated recycling of fluid, if control of fluid is not good all plants may be affected Requires a lot of labor, climate control of soil/roots is difficult
Soil
Greenhouse equipment
Greenhouse cover. Darkening curtain. Eco-lights. Heating/cooling
Growing tables
Lab analysis should include: edible products analysis, potency testing, microbiological screening, pesticide residue screening, For edible products: test to determine the total THC, CBN, and CBD present. Specifically, determine if the major
cannabinoids are decarboxylated properly, transforming the naturally occurring but inactive form of 9-THC-A (THCA) into active 9-THC (THC). THC is usually present at a quite low level in fresh plant material and is considered to be derived artificially from THCA by non-enzymatic decarboxylation during storage and consumption (e.g. smoking, vaporizing, or cooking).
Potency testing
Avermectin The active ingredient in AVID, a potentially harmful miticide. Pyrethoids The active ingredient in Pyrethrum, a potentially toxic insecticide. Organophosphates The active ingredients in a variety of insecticide products. Screen for the most commonly used organophosphates including parathion, malathion, methyl parathion, chlorpyrifos, diazion, dichlorvos, phosmet, tetrachlorvinphos, and azinos methyl
Use High Pressure Liquid Chromatography (HPLC) technology to directly quantify the total cannabinoid content of medical cannabis. Beginning with dry-weight determination, analyze the percentage of water contained in each sample to ensure proper preparation during the curing process. The quantification process then identifies and measures the amount of total THC (9THCA + 9THC + 8THC), Cannabinol (CBN), and Cannabidiol (CBDA + CBD). These key Cannabinoids give cannabis many medicinal properties
The following are possible microorganisms that may be detected through testing: Alternaria - A plant pathogen and allergen to humans. Exposure can cause hay fever and may evolve into asthma. Exposure can also cause infections in patients with immune system deficiencies. Aspergillus - One of the most deadly molds to humans. Some species have been known to produce large amounts of aflatoxin, a toxin & a carcinogen. Exposure can cause allergic reactions and/or infections in patients with immune system deficiencies. Botrytis A necrotrophic fungus that affects many plant species. It is also known as Grey Mold and Bud Rot.
Cladosporium A plant pathogen which can cause cannabis to reduce the size of the yield & quality. This is the group that contains the most common molds & generates no mycotoxins. Over exposure can cause asthma attacks and/or pneumonia in some patients. Escherichia Coli - Negative bacteria that lives in the mammalian gastrointestinal tract. Most strains of E. Coli are harmless , however several can cause food poisoning in humans. Penicillium - Exposure can cause severe allergic reactions in patients who are sensitive to the antibiotic Penicillin. Yeast - A group of microorganisms that are often found in cannabis. Some are pathogenic and/or allergenic & should be avoided by patients with immune system deficiencies
Source:
Results from lab analysis conducted for the Ministry of health 2007
Current distribution
Agency
+ Home delivery Patients Need Specialist Docs recommendation Distr. Through pharmacies
patients
Growers
1. Government establish the Medical Cannabis Agency to comply with UN drug conventions and for a complete regulation of MC 2. Government issues tender for growers Few growers are selected 3. Growers output All cannabis bought by the government 4. All cannabis is stored in government warehouse 5. Distributed to pharmacies 6. Patient purchase MC in participating pharmacies if they obtained specialist doctor recommendation 7. Home delivery option
Cost of medical cannabis (& extract medications) in various countries (In US Dollars)
USA
CANADA
Holland
Israel
$ 10 $21 gr. (average is $17 per gram) $300- $630 for 30 gr.
USD $ 10 gr. variety SIMM 18 per gr. (2005) $ 11 + per gr. for variety Bedrocan The prices are built up as follows: 1. the OMC's selling price per gram SIMM 18: $ 8.68 Bedrocan: $ 10.07 2. the pharmacy's fee:$ 7.44) per prescription +3. 6% tax
Exported:
in Germany $ 23.3 gr.
Some insight:
This open pilot study was designed to test (29 subjects) the effects of smoked cannabis on symptoms of chronic combat PTSD (Post Traumatic Stress Syndrome) Smoked medical indica cannabis of roughly 23% THC and less than 1% CBD was dispensed to the subjects: at an amount of no more than 100 grams per month (based on their licenses limit and set at a high level to thwart undue distress) Cannabis was added to subjects' standing treatment Subjects were instructed to smoke the cannabis daily at times, frequencies and amounts of their own choosing until they felt relaxed.
Bedrocan
19%
<1%
Bedrobinol
12%
<1%
Bediol
6%
About 7.5%
oil
Crystals
flowers
mixture
Due to higher THC content, patients need consume only a fraction of the harmful, non.medically-active tars and gases in cannabis smoke in order to achieve the same effective dose
(USA - Recreational)
1. Cleaned & dried, Cannabis flowers 2. Cannabis laced brownies 3. Ready made joints 4. Vaporizers (approved for use in hospitals) 5. Oil in small bottles with peptide
A trade-off exists between the number of bottles and the weight of dried flowers a patient can receive
Office of Medical Cannabis Netherlands info. for patients There are different types of medicinal cannabis varieties available. These varieties differ from each other in composition, and strength, and therefore also in operation. In the pharmacy are three varieties available: Bedrocan, Bedrobinol and Bediol (see table). The variety that is most suitable to a patient depends on the symptoms and reaction differs from person to person. In consultation with the doctor determine which variety is the best choice for you. There is evidence that cannabis with a combination of a high content of THC and CBD (such as Bediol) provides MS patients good relief from the pain.
What are you suffering from? How bad is it (1-10)? For how long? What kind of medications have you been using? Do you have experience with cannabis? Do you know how to roll joints? Have you ever smoked cigarettes? Do you have kids or minors in your house? Do you have someone to take your cannabis from the distribution center? Do you have someone to be with you in the house while you smoke the MC? These are the possible side effects (*)
Psychotic episodes Panic attacks Generalized Anxiety Disorder A-motivational Disorder
(*)The side effects are quoted from a presentation of Dr. Y. Baruch, the director of the MC program and a
psychiatrist
Americans for Safe Access (ASA USA) Patient Education Guide to Using Marijuana
Smoking Vaporizing
Tincture Compress Rectal THC Eating Tea Marinol
Side effects
Patients generally tolerate medicinal cannabis well. A low dosage often provides sufficient relief, so that side effects rarely occur. When they do, it is usually the result of a high dosage or combined use with a substance such as alcohol that intensifies the side effects. Known side effects of medicinal cannabis are: mood-altering effects, insomnia and heart palpitations. Other effects are: relaxation, fits of laughter, feeling hungry, heightened sensitivity to the perception of e.g. color and music, lethargy and distorted temporal and spatial awareness. Your reaction time may also be slower, especially during the first hours after use. If you take a large dose, you can get high. This is a feeling of euphoria which slowly subsides into feeling satisfied, peaceful and calm. The altered perception may cause you to feel confused. These effects usually disappear after a few hours. If you have a genetic predisposition to psychosis (like schizophrenia) or other mental health problems, please consult your specialist before using medicinal cannabis. You should also consult your doctor if you are a cardiac patient. Continuous use of cannabis during pregnancy can affect the fetus. Also, certain components of cannabis - like THC - end up in breast milk. That is why the use of medicinal cannabis is not advisable during pregnancy and while breastfeeding. For more information, consult your doctor or pharmacist.
Smoking cannabis regularly is bad for your health. Smoke damages the lungs and could lead to infections of the nose, throat and lungs. For this reason, smoking medicinal cannabis is not recommended. Instead, inhaling cannabis using a reliable vaporiser is a more suitable method.
If you want to make tea for several days, use 1 gram (about 4 teaspoons or 2 measuring scoops) of medicinal cannabis for one litre of water. Then, add a package or teaspoon of coffee creamer powder to the warm tea. This will keep the active substances in the tea from sticking to the inside of the teapot or cup, reducing its effectiveness. Let the tea cool down and store it in the fridge. It will keep for several days. You may reheat the refrigerated tea, and can add sugar, syrup or honey to improve its taste.
Dosage
Start by drinking 1 cup (0.2 liters) of tea in the evening. If this provides insufficient relief after one or two weeks, you can in consultation with your doctor drink an extra cup (0.2 liters) in the morning. If the tea still provides insufficient relief, ask your doctor about inhaling medicinal cannabis using a vaporizer. Inhalation acts faster, and its effect is stronger than cannabis tea. Furthermore, the dose is easier to adjust. ______________________________________________________________ Bedrocan and Bedrobinol are available in the form of dried flower tips (flos). Bediol is provided as granules, as the flower tips have been crushed. All three varieties can be used to make tea or inhaled through an inhaler. It doesn t matter if you use the granules or the flower tips.
Inhalation To inhale medicinal cannabis we advise you to use a reliable vaporizer. Vaporizers with instructions are obtainable in the Netherlands from Stichting NCSM (Volcano) and in pharmacies. The pharmacies order the vaporizers from Fagron BV.
Dosage:
The initial dose should be about 200 mg (1 teaspoon or measuring scoop). Place this in the vaporizer, heat the cannabis, then inhale once. Wait 5 to 15 minutes before inhaling again. Repeat this a few times including the interval between two inhalations until the desired effect is achieved, or until the onset of undesirable side effects (physical or mental). Start by performing this procedure once or twice a day. Its important that you gradually build up your intake. Inhaling several times a day can only be considered after some time has elapsed. Always consult your doctor first, since the dosage and amounts used vary widely between individual patients. Smoking cannabis with or without tobacco is not recommended, nor is using a water pipe as harmful chemicals are also inhaled.
Conclusion: Under UN conventions MC can be grown and consumed as part of a medical and scientific research program. This requires submitting an authorization for a (simple) observational clinical research request to authorities to launch the MC program. Call the MC program A national MC scientific research program as first stage. If the authorities refuse to approve the MC research program take them to court to fulfill their obligation to UN drug conventions and their expose their cruelty to reduce pain and suffering among sick people
1. A Party that permits the cultivation of the (opium poppy) CANNABIS for the production of (opium) CANNABIS shall establish, if it has not already done so, and maintain, one or more government agencies (hereafter in this article referred to as the Agency) to carry out the functions required under this article. 2. Each such Party shall apply the following provisions to the cultivation of (the opium poppy) CANNABIS for the production of (opium and to opium) CANNABIS: a) The Agency shall designate the areas in which, and the plots of land on which, cultivation of the (opium poppy) CANNABIS for the purpose of producing (opium) CANNABIS shall be permitted. b) Only cultivators licensed by the Agency shall be authorized to engage in such cultivation. c) Each license shall specify the extent of the land on which the cultivation is permitted.
1. 2.
3.
4.
Authorities are addicted to the status-quo drug and are not impressed by facts, truth or acts of compassion. Talk the language authorities talk point to how their & the countrys interests will be served, (electoral support, savings money on other medications etc.) Be brief. Prepare a book of abstracts to show that Cannabis is well researched/studied, safe and effective medicine. Lay out a plan that would not cost the state too much money, if at all.
6. 7. 8. 9.
10 common reasons used by governments why not to launch a Medical Cannabis program:
1. Cannabis has no medical value (false) 2. Not enough research/clinical results (false) 3. Conventional treatments are good enough (false) 4. Cannabis is addictive, damaging and also illegal (mostly false) 5. No medicine has been approved in the form of smoking (true but ) 6. Prohibited by UN Drug conventions (false) 7. No good way to control the production and distribution (false) 8. The police/public is against it (false) 9. It is a cover for cannabis legalization (false) 10. During times of recession, the government cant fund such a program (false)