cancerisbadembryo.com The Oncogerminative Theory of Cancer Development by Dr. Vladimir Vinnitsky, M.D., Ph.D., D.Sc.

Oncogerminative Model of Cancer Development The Theory proposed a new Oncogerminative Model of Cancer Development, which explains the set of malignant properties common to all types of solid cancers: Cancer starts with a reprogramming of a mortal somatic cell into a potentially immortal mimic germ-line cell which is cancer stem cell. The malignant reprogramming of a somatic cell lies in its germinalization: the switching over of its somatic cells genetic program to the germ-line cells genetic program with a subsequent awakening of a dormant tool of its potential immortality. This means that like an immortal germ-line cell a cancer stem cell realized its potential immortality by performing of its life cycle. Therefore we named a cancer stem cell oncogerminative cell. A distinguishing characteristic of any cancer stem cell is its aspiration to realize its potential immortality by passing through its life-cycle and developing a mimic blastula-stage embryo, which in fact manifests in host body as a malignant tumor. Malignant tumor development is a multi-stage event which includes: The First stage parthenogenetic multiplication of oncogerminative cells. (This stage mimics cleavage-stage embryo) The Second stage aggregation of oncogerminative cells and formation of tumor germ. (This stage mimics morula-stage embryo) The Third stage tumor germ becomes a tumor spheroid with a heterogeneous cell population, which consists of malignant oncogerminative and oncotrophoblastic cells, and non-malignant oncosomatic cells. (This stage mimics avascular blastocyst-stage embryo) The Fourth stage vascularization of the tumor spheroid and its further growth as a vascularized tumor. (This stage mimics post-implantation blastocyst-stage embryo) The Fifth stage disaggregation of oncogerminative cells and it metastatic spreading within body tissues. (This stage mimics primordial germ cells migration) Only oncogerminative cell is able to develop a metastatic tumor. After settling in host body tissues, a metastatic oncogerminative cell may repeat its life cycle again and give rise to new generation of metastatic tumor. A circulating oncogerminative cell alone is unable to implant, invade, and to develop a metastatic tumor. Just as a fertilized germ-line cell creates a blastocyst before the implantation, a circulating oncogerminative cell must first create a multicellular structure (tumor spheroid) in order to proceed with the development of a new metastatic tumor. Cancer and embryo share similar defense mechanisms that protect it against host-versus-graft immune response. In case of embryo such mechanisms are transient and are restricted by the term of pregnancy. Unlike embryo cancer is protected by such mechanisms constantly. Cancer is a phenomenon of developmental biology, which we have termed a desperate asexual self-cloning event. In mammals this phenomenon manifests by cancer development which represents desperate attempt of cancer stem cell to implement it potential immortality by cloning the host body. From the standpoint of developmental biology to have a cancer is the same as to be gestating with a bad embryo. In order to get rid of cancer the host body needs help to give birth to malignant tumor forcibly. Ideally that means the removal of critical mass of cancer cells combined with the overcoming of selective immune tolerance toward remaining metastatic cancer cells. We welcome you to our new website cancerisbadembryo.com