HLA A HLA B HLA C

What are the MHCI Human Leukocyte Antigen types?

HLA DR HLA DP HLA DQ

What are the MHCII Human Leukocyte Antigen types?

A3 MHCI

HLA subtype: hemochromatosis? Is this MHCI or MHCII?

B27 MHCI

HLA subtype: Psoriasis? Is this MHCI or MHCII?

B27 MHCI

HLA subtype: Ankylosing sponylitis? Is this MHCI or MHCII?

B27 MHCI

HLA subtype: Inflammatory Bowel Disease? Is this MHCI or MHCII? HLA subtype: Reiter Syndrome? Is this MHCI or MHCII?

B27 MHCI

B8 MHCI

HLA subtype: Grave Disease? Is this MHCI or MHCII?

DR2 MHCII 4

HLA subtype: Multiple Sclerosis? Is this MHCI or MHCII? What HSR type?

DR2 MHCII

HLA subtype: hay fever? Is this MHCI or MHCII?

DR2 MHCII 3

HLA subtype: SLE? Is this MHCI or MHCII? What HSR type? HLA subtype: Goodpasture? Is this MHCI or MHCII? What HSR type? HLA subtypes: Diabetes Mellitus Type I? Is this MHCI or MHCII? What antibody?
HLA subtype: Rheumatoid Arthritis? Is this MHCI or MHCII? What antibody? What HSR type?

DR2 MHCII 2 DR3 DR4 MHCII Anti glutamate decarboxylase DR4 MHCII anti IgG 3 DR5 MHCII 2

HLA subtype: Pernicious Anemia? Is this MHCI or MHCII? What HSR type?

DR5 MHCII 4 anti microsome anti thyroglobulin

HLA subtype: Hashimoto Thyroiditis? Is this MHCI or MHCII? What HSR Type? what antibodies? HLA subtype: Steroid Responsive Nephrotic Syndrome? Is this MHCI or MHCII?
In order to be activate T cells, antigen must be present by MHC. This does not happen without a peptide component to the antigen. Thus, antigen that lacks a peptide compoment does not generate class switch or memory. These antigens are termed what?

DR7 MHCII

Thymus independent

pemphigus vulgaris

Type 2 HSR (antibody to cell surface antigen). Anti desmoglein (a cadherin).

spleen follicle

What organ is this? Where are the B cells?

spleen PALS

What organ is this? Where are the T cells?

marginal zone macrophages

Where are the cells that clear encapsulated organisms? What are these cells?

Salmonella S. pneumoniae H. influenzae Neisseria meningitidis

Macrophages in the spleen marginal zone clear encapsulated organisms. What are the encapsulated bacteria?

Marginal zone Red Pulp

Where are the APCs in the spleen? Where are the RBCs?

lymph node paracortex

What organ is this? Where are the T cells?

follicle medullary cords

Where are the b cells in the spleen? where are the plasma cells?

germinal center
What histological differentiates an active B cell producing follicle (2nd degree) from an inactive 1st degree follicle?

high endothelial venule

B cells and T cells gain entrance to the lymph node from the blood thru this structure?

paracortex 22q11
What are of the lymph node is small with DiGeorge Syndrome and large during a severe cell mediated response (to virus)? What is the microdeletion of DiGeorge syndrome?

medullary sinus
Where are the macrophages of the lymph node?

thymus cortex

What organ is this? Where are the immature T cells?

cortex
Where does positive selection (MHC restriction) of T cells occur in the thymus?

medulla
Where does negative selection (prevent self reactivity) of T cells occur in the thymus?

medulla
Where are the mature T cells found in the thymus

DAF Paroxysmal Nocturnal Hemoglobinuria C1 esterase inhibitor Hereditary angioedema

There are 2 OFF switches for complement, functional deficiencies of which describe disease. What are the OFF switches and associated diseases?

viral neutralization
C1-4 function in addition to cascade?

C3a C5a
Anaphylactic components of complement?

C5a
Complement neutrophil attractant?

C5-8
Deficiency->neisseria bacteremia?

gramThe Membrane Attack Complex defends primary against what?

C3
Deficiency->recurrent pyogenic sinus/respiratory infections and susceptibility to Type 3 HSR (Antibody to antigen).

IgM IgG
Antibodies capable of activated the classic pathway?

Bruton agammaglobulinemia X linked recessive Bruton Tyrosine Kinase 6 months maternal IgG

B cell disorder=blocked maturation;differentiation. Recurrent Pyogenic Infections. What disease? What inheritence? What is the defective gene? At what age would infections start? Why not before this age?
Immunesuppressant: Blocks calcineurin. Calcineurin->+NFaT c NFaT c->transcibes IL2. What drug? What cells is activated by IL2? Along with treatment for certain autoimmune diseases, what is this drug used for?

cyclosporine CD8+ T suppress transplant rejection

nephrotoxic mannitol diuretics

What is the non-immunology toxicity of cyclosporine? What is used in conjunction to prevent this?

sirolimus rapamycin kidney transplant

Immunosuppressant. Binds mTOR. Prevents CD8+ proliferative in response to IL2. What drug? Used to prevent rejection after what procedure?

sirolimus rapamycin CD8+ T IL2

Immunosuppressant with toxicity: Hyperlipidemia. Neutropenia. Thrombocytopenia. What drug? Blocks which cell from responding to which cytokine?

macrophage Th1 differentiation

Which cell produces IL12? What process does it drive?

These cytokinase act upregulate ribonuclease in uninfected cells->prevents translation of viral rna. Monoclonal antibody to IL2 receptor (CD8+T). Prevents renal transplant acute rejection.

interferon

daclizumab

Chronic Granulomatous Disease NADPH oxidase neutrophils Chediak Higashi Syndrome microtubule phagocytosis Leukocyte Adhesion Deficiency type 1 CD18 LFA1 integrin

Immune deficiency: Susceptible to catalase+ organisms? What enzyme is deficient? What cells primarily? Immune deficiency: Recurrent staph/strept. Albinism. Peripheral neuropathy? What cell component is defective? What process is disrupted? Immune deficiency: Recurrent bacterial infection. No Pus formation. Delayed separation of umbilicus? What is defective? Immune deficiency: Thrombocytopenic purpura. Infections. Eczema? What inheritence?

Wiskott Aldrich Syndrome X linked recessive

DNA repair enzymes IgA

Ataxia Telangiectasia is an immune deficiency that is the result of a defect in what? What Ig is deficient?