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MARY YVETTE ALLAIN TINA RALPH SHERYL BART HEINRICH PIPOY KC JAM CECILLE DENESSE VINCE HOOPS CES XTIAN LAINEY RIZ KIX EZRA GOLDIE BUFF MONA AM MAAN ADI KC
PENG KARLA ALPHE AARON KYTH ANNE EISA KRING CANDY ISAY MARCO JOSHUA FARS RAIN JASSIE MIKA SHAR ERIKA MACKY VIKI JOAN PREI KATE BAM AMS HANNAH MEMAY PAU
RACHE ESTHER JOEL GLENN TONI
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üCognition and sometimes consciousness are ü Scalp hair falls out easily, eventually becoming
impaired. sparse, but eyelash hair may grow excessively.
üTemporary lactose deficiency and achlorhydria ü Alternating episodes of undernutrition and
develop. adequate nutrition may cause the hair to have a
üDiarrhea is common and can be aggravated by dramatic “striped flag” appearance.
deficiency of intestinal disaccharidases, ü Total starvation is fatal in 8 to 12 wk. Thus, certain
especially lactase (see Malabsorption Syndromes: symptoms of PEM do not have time to develop. be
Etiology). apathetic but become irritable when held.
üGonadal tissues atrophy.
ü PEM can cause amenorrhea in women and DIAGNOSIS
loss of libido in men and women. Ø Diagnosis can be based on history when
Ø Wasting of fat and muscle is common in all dietary intake is markedly inadequate. The
forms of PEM. In adult volunteers who fasted cause of inadequate intake, particularly in
for 30 to 40 days, weight loss was marked children, needs to be identified. In children
(25% of initial weight). If starvation is more and adolescents, child abuse and anorexia
prolonged, weight loss may reach 50% in nervosa should be considered.
adults and possibly more in children. Ø Physical examination findings can usually
Ø Wasting (called cachexia in adults) is most confirm the diagnosis.
obvious in areas where prominent fat depots Ø Laboratory tests are required to identify
normally exist. Muscles shrink and bones causes of secondary PEM.
protrude. The skin becomes thin, dry, üMeasurement of plasma albumin,
inelastic, pale, and cold. The hair is dry and
ü total lymphocyte count, CD4+ T lymphocytes,
falls out easily, becoming sparse. Wound
and
healing is impaired. In elderly patients, risk of
ü response to skin antigens may help determine
hip fractures and decubitus ulcers increases
the severity of PEM (see Table 3: Undernutrition:
Values Commonly Used to Grade the Severity of
Ø With acute or chronic severe PEM, heart size
Protein-Energy Malnutrition )or confirm the diagnosis
and cardiac output decrease; pulse slows and
in borderline cases.
blood pressure falls. Respiratory rate and vital
capacity decrease. Body temperature falls,
ü Measurement of C-reactive protein or soluble
sometimes contributing to death. Edema,
interleukin-2 receptor should be measured when the
anemia, jaundice, and petechiae can develop.
cause of undernutrition is unclear ; these
Liver, kidney, or heart failure may occur.
measurements can help determine whether there is
Ø Cell-mediated immunity is impaired,
cytokine excess.
increasing susceptibility to infections.
üMany other test results may be abnormal: eg,
üBacterial infections (eg, pneumonia,
decreased levels of hormones, vitamins, lipids,
gastroenteritis, otitis media, UTIs, sepsis) are common
cholesterol, prealbumin, insulin (HUMULIN NOVOLIN)
in all forms of PEM
growth factor-1, fibronectin, and retinol-binding
. ü Infections result in release of cytokines, which protein.
produce anorexia, worsen muscle wasting, and cause
ü Urinary creatine and methylhistidine levels can
a marked decrease in serum albumin levels.
be used to gauge the degree of muscle wasting.
Ø Marasmus in infants causes hunger, weight ü Because protein catabolism slows, urinary
loss, growth retardation, and wasting of urea level also decreases. These findings rarely affect
subcutaneous fat and muscle. treatment.
ü Ribs and facial bones appear prominent. Loose,
thin skin hangs in folds. Table 3. Values Commonly Used to Grade the Severity of
Protein-Energy Malnutrition
Ø Kwashiorkor is characterized by peripheral
edema. Measurement:
ü The abdomen protrudes, but there is no ascites. Ø Normal ---------------------- 90–110 (%)
ü The skin is dry, thin, and wrinkled; it can become Ø Mild Malnutrition------------85–90 (%)
hyperpigmented and fissured and later Ø Moderate Malnutrition ----75–85 (%)
hypopigmented, friable, and atrophic. Ø Severe Malnutrition -------<75 (%)
ü Skin in different areas of the body may be Body mass index
affected at different times. Normal ------------------------ 19–24*
ü The hair can become thin, reddish brown, or gray. Mild Malnutrition------------18–18.9
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Moderate Malnutrition ----16–17.9 urinalysis,
Severe Malnutrition ------- < 16 urine culture,
Serum albumin (g/dL) blood cultures,
Normal-----------3.5–5.0 tuberculin testing, and
Mild---------------3.1–3.4 a chest x-ray are used to diagnose occult
Moderate--------2.4–3.0 infections because people with PEM may
Severe---------< 2.4 have a muted response to infections.
Serum transferrin (mg/dL) PREVENTION AND TREATMENT
Normal-----------220–400 Ø Worldwide, the most important preventive
Mild---------------201–219 strategy is to reduce poverty and improve
Moderate--------150–200 nutritional education and public health
Severe-----------< 150 measures.
Total lymphocyte count (per mm3) Ø Mild or moderate PEM, including brief
Normal--------------2000–3500 starvation, can be treated by providing a
Mild------------------1501–1999 balanced diet, preferably orally.
Moderate-----------800–1500
Ø Liquid oral food supplements (usually lactose-
Severe--------------< 800
free) can be used when solid food cannot be
Delayed hypersensitivity index†
adequately ingested.
Normal---------2
Ø Diarrhea often complicates oral feeding
Mild-------------2
because starvation makes the GI tract more
Moderate------1
likely to move bacteria into Peyer's patches,
Severe---------0
facilitating infectious diarrhea. If diarrhea
persists (suggesting lactose intolerance),
In the elderly,
yogurt-based rather than milk-based formulas
üBMI < 21 may increase mortality risk.
are given because people with lactose
ü †Delayed hypersensitivity index quantitates the intolerance can tolerate yogurt.
amount of induration elicited by skin testing using a Patients should also be given a multivitamin
common antigen, such as those derived from Candida supplement
sp or Trichophyton sp.
ü Induration
• Severe PEM or prolonged starvation requires
grade 0 = < 0.5 cm, treatment in a hospital with a controlled diet.
grade 1 = 0.5–0.9 cm, üThe first priority is to correct fluid and electrolyte
grade 2 = ≥ 1.0 cm. abnormalities (see Fluid and Electrolyte Metabolism)
Other laboratory tests can detect associated and treat infections.
abnormalities that may require treatment. ü Next is to supply macronutrients orally or, if
üSerum electrolytes, necessary, through a feeding tube, a nasogastric tube
ü BUN, (usually), or a gastronomy (G) tube.
ü glucose, and ü Parenteral nutrition is indicated if malabsorption is
severe (see Nutritional Support: Total Parenteral
ü possibly levels of Ca,
Nutrition (TPN)).
ü Mg,
ü Other treatments may be needed to correct
ü phosphate,
specific deficiencies, which may become evident as
ü and Na should be measured. weight increases.
Ø Levels of blood glucose and electrolytes ü To avoid deficiencies, patients should continue to
(especially K, phosphate, Ca, and Mg and take micronutrients at about twice the recommended
occasionally Na) are usually low. daily allowance (RDA) until recovery is complete.
Ø BUN is often low unless renal failure is IN CHILDREN:
present. • Underlying disorders should be treated.
Ø Metabolic acidosis may be present.
ü For children with diarrhea, feeding may be delayed
Ø CBC is usually obtained; normocytic anemia for 24 to 48 h to avoid making the diarrhea worse.
(usually due to protein deficiency) or
Feedings are given often (6 to 12 times/day) but,
microcytic anemia (due to simultaneous iron
to avoid overwhelming the limited intestinal absorptive
deficiency) is usually present.
capacity, are limited to small amounts (< 100 mL).
üStool cultures should be obtained and checked
During the first week, milk-based formulas with
for ova and parasites if diarrhea is severe or does
supplements added are usually given in progressively
not resolve with treatment.
increasing amounts;
üSometimes:
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after a week, the full amounts of 175 kcal/kg and Anabolic steroids have positive effects (eg, increase
4 g of protein/kg can be given. lean body mass, possibly improve function) in patients
Twice the RDA of micronutrients should be given, with cachexia due to renal failure and possibly in
using commercial multivitamin supplements. elderly patients
After 4 wk, the formula can be replaced with Correction of PEM in adults
whole milk plus cod liver oil and solid foods, including ügenerally resembles that in children.
eggs, fruit, meats, and yeast. ü For most adults, feeding does not need to be
delayed;
• Energy distribution among macronutrients should ü small volumes are given often.
be: ü A commercial formula for oral feeding can be
ü about 16% protein, used.
ü 50% fat, and ü Nutrient supply should be given at a rate of 60
ü 34% carbohydrate. kcal/kg and 1.2 to 2 g of protein/kg.
ü An example is ü If liquid oral supplements are used with solid food,
they should be given at least 1 h before meals so
a combination of powdered cow's skimmed milk that the amount of food eaten at the meal is not
(110 g), sucrose (100 g), vegetable oil (70 g), and reduced
water (900 mL). ü Treatment of institutionalized elderly patients
Many other formulas (eg, whole [full-fat] fresh with PEM requires multiple interventions,
milk plus corn oil and maltodextrin) can be used. ü including environmental measures (eg, making the
Milk powders used in formulas are diluted with dining area more attractive);
water. ü feeding assistance;
Usually, supplements should be added to formulas: ü changes in diet (eg, use of food enhancers and
- Mg 0.4 mEq/kg/day IM is given for 7 days; caloric supplements between meals);
- B-complex vitamins at twice the RDA are given ü treatment of depression and other underlying
parenterally for the first 3 days, usually with disorders;
vitamin A, ü and the use of orexigenics, anabolic steroids, or
- phosphorus, zinc, manganese, copper, iodine, both.
fluoride, molybdenum, and selenium ü The long-term use of gastrostomy tube feeding is
SELSUN essential for patients with severe dysphagia; its use in
(More in Mosby's Drug Consult) patients with dementia is controversial
Because absorption of oral iron is poor in children ü Increasing evidence supports the avoidance of
with PEM, oral or IM iron supplementation may be unpalatable therapeutic diets (eg, low salt, diabetic,
necessary. low cholesterol) in institutionalized patients because
Parents are taught about nutritional requirements these diets decrease food intake and may cause
severe PEM.
IN ADULTS: Complications of treatment:
üDisorders associated with PEM should be treated. Treatment of PEM can cause complications (refeeding
üFor example, if AIDS or cancer results in excess syndrome), including:
cytokine production, megestrol acetate or ü fluid overload,
medroxyprogesterone may improve food intake. ü electrolyte deficits,
üHowever, because these drugs dramatically ü hyperglycemia,
decrease testosterone Trade Names DELATESTRYL ü cardiac arrhythmias, and
in men (possibly causing muscle loss), testosterone ü diarrhea.
DELATESTRYL should be replaced.
Diarrhea is usually mild and resolves;
ü Because these drugs can cause adrenal
however, diarrhea in patients with severe PEM
insufficiency, they should be used only short-term (< 3
occasionally causes severe dehydration or death.
mo).
Causes of diarrhea (eg, sorbitol used in elixir tube
üIn patients with functional limitations, home delivery
feedings, Clostridium difficile if the patient has
of meals and feeding assistance are key.
received an antibiotic) may be correctable.
Ø An orexigenic drug, such as the cannabis extract
Osmotic diarrhea due to excess calories is rare in
dronabinol ARINOL, should be given to patients
adults and should be considered only when other
with anorexia when no cause is obvious or to
causes have been excluded.
patients at the end of life when anorexia impairs
quality of life. üBecause PEM can impair cardiac and renal function,
hydration can cause intravascular volume overload.
ü Treatment decreases extracellular K and Mg.
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üDepletion of K or Mg may cause arrhythmias. •Very young children may develop mild mental
ü Carbohydrate metabolism that occurs during treatment retardation, which may persist until at least
stimulates insulin) release, which drives phosphate into school age.
cells. • Permanent cognitive impairment may occur,
Ø caused by a prolonged QT interval. depending on the duration, severity, and age
Ø Hypophosphatemia can cause muscle weakness, at onset of PEM.
paresthesias, seizures, coma, and arrhythmias. Key Recommendations for the General Population
With parenteral feeding, phosphate levels should
be measured regularly. ADEQUATE NUTRIENTS WITHIN CALORIE NEEDS
ü During treatment, endogenous insulin • Consume a variety of nutrient-dense foods
(HUMULIN NOVOLIN More in Mosby's Drug Consult) and beverages within and among the basic
may become ineffective, leading to hyperglycemia. food groups while choosing foods that limit the
ü Dehydration and hyperosmolarity can result. intake of saturated and trans fats, cholesterol,
üFatal ventricular arrhythmias can develop, possibly added sugars, salt, and alcohol.
• Meet recommended intakes within energy
PROGNOSIS: needs by adopting a balanced eating pattern,
• In children, mortality varies from 5 to 40%. such as the U.S. Department of Agriculture
• Mortality rates are lower in children with (USDA) Food Guide or the Dietary
milder PEM and those given intensive care. Approaches to Stop Hypertension (DASH)
• Death in the first days of treatment is usually Eating Plan.
due to electrolyte deficits, sepsis,
hypothermia, or heart failure.
• Impaired consciousness, jaundice, petechiae,
hyponatremia, and persistent diarrhea are
ominous signs.
• Resolution of apathy, edema, and anorexia
are favorable signs.
• Recovery is more rapid in kwashiorkor than in
marasmus.
• Long-term effects of PEM in children are not
fully documented.
• Some children develop chronic malabsorption
and pancreatic insufficiency.
• Very young children may develop mild mental
retardation, which may persist until at least
school age.
• Permanent cognitive impairment may occur,
depending on the duration, severity, and age
at onset of PEM.
• In adults, PEM can result in morbidity and
mortality (eg, progressive weight loss
increases mortality rate by 10% for elderly Basic of a healthy diet
people in nursing homes). 1. Balance- a diet consisting of Carbohydrate at 50-
• Except when organ failure occurs, treatment 60%, Protein at 10-15% maximum of 20% and
is uniformly successful. Fats at 20- 30% of total calories.
• In elderly patients, PEM increases the risk of 2. Moderation- Dietitian help clients learn to plan
morbidity and mortality due to surgery, food portion sizes appropriately.
infections, or another disorder. - involves learning the distinct difference between
• Recovery is more rapid in kwashiorkor than in hunger satisfaction and fullness.
marasmus. 3. Variation- All healthy diets involve the inclusion of
• Long-term effects of PEM in children are not several food-types, to obtain required amount of
fully documented. essential nutrients. Helps avoid food-boredom.
• Some children develop chronic malabsorption
and pancreatic insufficiency.
* Source: WholeFitness.com
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• Underwater measurement
• Dual energy XRay Absorptiometry (DEXA)
• FAT Thickness
• Bio-Cutaneous Meter
Treatment: EXERCISE
-30-60 minutes of aerobic exercise 3-4 times a Cholesterol
week • Risk of heart disease increases as
-Increase physical activity at home and at work Cholesterol increases
Treatment: DRUGS • Good cholesterol – HDL > 35 mg/dl
• Bad cholesterol – LDL < 130 mg/dl
Top 10 Benefits of Being Active • Low fat, low cholesterol diet
1. Improve blood glucose management. Activity
• Fruits and vegetables
makes your body more sensitive to the insulin you
make. Activity also burns glucose (calories). Both • 20-30 mins. Exercise - 3 days a week
actions lower blood glucose.]
2. Lower blood pressure. Activity helps your heart Supplements to Boost your Health
pump stronger and slower. Vitamin B12 – needs stomach acid to be absorbed
** supplement form- No Acid needed
3. Improve blood fats. Exercise can raise good Symptoms:
cholesterol (HDL) and lower bad cholesterol (LDL)
• Anemia
and triglycerides. These changes are heart
healthy. • Blood cell disorders
4. Take less insulin or diabetes pills. Activity can • Neurological disorders
lower blood glucose and weight. Both of these • Changes in gait
may lower how much insulin or diabetes pills you 2.4 microgr/day
need to take. Folate ( Folic acid)
5. Lose weight and keep it off. Activity burns calories. • B Vitamin that reduces levels of
If you burn enough calories, you'll trim a few HomoCysteine
pounds. Stay active and you'll keep the weight off. • Found in dark green, yellow and orange
6. Lower risk for other health problems. Reduce fruits and vegetables
your risk of a heart attack or stroke, some • Beans, nuts, fortified grain products –
cancers, and bone loss pasta and flour
7. .Gain more energy and sleep better. You'll get
• Spinach, orange juice and lentils
better sleep in less time and have more energy,
Calcium and Vitamin D
too.
o 1,200 microgm/day
8. Relieve stress. Work out or walk off daily stress.
9. Build stronger bones and muscles. Weight- o Calcium carbonate – citrate
bearing activities, such as walking, make bones o Skin – main producer of Vitamin D
stronger. Strength-training activities, such as lifting o Elderly people – 10 – 15 mg/ day
light weights (or even cans of beans), make
muscles strong.
10. Be more flexible. Move easier when you are “…DIETARY SUPPLEMENTS ARE NOT DIETARY
active. SUBSTITUTES…”