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1.) MEBENDAZOLE is a (synthetic) broad- Indications and Usage: • Your doctor has prescribed this
spectrum anthelmintic available as chewable Mebendazole tablets are indicated for the medicine to treat an infection caused
tablets, each containing 100 mg of treatment of Enterobius vermicularis by an intestinal worm. Follow your
Mebendazole. Inactive ingredients are: (pinworm), Trichuris trichiura (whipworm), doctor’s instructions carefully. In
anhydrous lactose NF, corn starch, magnesium Ascaris lumbricoides (common roundworm), addition to your doctor’s treatment,
stearate, microcrystalline cellulose, sodium Ancylostoma duodenale (common you can help prevent reinfection and
lauryl sulfate, sodium saccharin, sodium hookworm), Necator americanus (American infection of other people by
starch glycolate, stearic acid, and FD&C hookworm) in single or mixed infections. understanding a few simple facts about
Yellow #6. worms.
Contraindications: • PINWORM: Pinworms look like tiny
Mebendazole is contraindicated in persons white threads and live in the bowel.
who have shown hypersensitivity to the drug. Usually at night, they travel to the
rectal opening and lay eggs on the
Adverse Reactions: outside skin. This sometimes causes
Gastrointestinal: itching which may be very annoying.
Transient symptoms of abdominal pain and That is why restless sleep is a frequent
diarrhea in cases of massive infection and sign of pinworms, especially in
expulsion of worms. children. Scratching will cause
Hypersensitivity: pinworm eggs to stick to the fingers.
Rash, urticaria and angioedema have been Reinfection will result if the fingers are
observed on rare occasions. placed in the mouth.
To help prevent reinfection follow these
Central Nervous System: rules:
Very rare cases of convulsions have been
• Wash hands and fingernails with soap
reported.
often during the day, especially before
Liver:
eating and after using the toilet.
There have been liver function test elevations
• Wear tight underpants both day and
[AST (SGOT), ALT (SGPT), and GGT] and
night. Change them daily.
rare reports of hepatitis when Mebendazole
• For several days after treatment, clean
was taken for prolonged periods and at
dosages substantially above those the bedroom floor by vacuuming or
Neutropenia and agranulocytosis. (See • After treatment, wash bed linens and
2.) DOMPERIDONE (trade name Motilium, Indications and Usage: Patient Consultation:
Motillium or Costi) is an antidopaminergic As an aid to patient consultation, refer to
Gastrointestinal problems:
drug, developed by Janssen Pharmaceutica, Advice for the Patient, Domperidone
and used orally, rectally or intravenously, (Systemic).
Domperidone is used, together with
generally to suppress nausea and vomiting. It In providing consultation, consider
metoclopramide, cyclizine, and 5HT3 receptor
has also been used to stimulate lactation. emphasizing the following selected
antagonists (such as granisetron) in the
information (» = major clinical significance):
treatment of nausea and vomiting.
Domperidone has also been found effective in
Before using this medication
» Conditions affecting use, especially:
the treatment of gastroparesis, a stomach
Sensitivity to domperidone
motility condition, and for paediatric
Gastroesophageal reflux (infant vomiting). Pregnancy:
Side/adverse effects:
Effects:
Asthenia, change in urinary frequency, CNS
Domperidone elevates serum prolactin effects (dry mouth, headache, nervousness,
concentrations. dizziness, thirst, irritability), conjunctivitis,
dysuria, edema, endocrinological effects (hot
flushes, menstrual irregularities, mastalgia,
galactorrhea, and gynecomastia,
extrapyramidal effects (difficulty in speaking
and loss of balance or muscle control),
gastrointestinal effects (abdominal cramps,
diarrhea, heartburn, constipation, and changes
in appetite), leg cramps, lethargy, palpitations,
pruritus, stomatitis, and urticaria
Treatment of overdose:
There is no specific antidote or specific agent
for domperidone overdose. However,
anticholinergic agents , antiparkinsonian
medications, or antihistamines with
anticholinergic properties may be useful in
controlling the extrapyramidal reactions
associated with domperidone toxicity.
To enhance elimination :
Gastric lavage as well as the administration of
activated charcoal may be useful in facilitating
the elimination of domperidone.
Supportive care:
Close observation and supportive therapy are
recommended.
Patients in whom intentional overdose is
confirmed or suspected should be referred for
psychiatric consultation.