& http://apecexam.com/mod/quiz/attempt.php?q=1&page=0 1 Marks: --/1 Autoclaving is usually undertaken at Choose one answer. a. 121 C for 15 minutes b.

111 C for 15 minutes c. 121 C for 30 minutes d. None of these options e. 111 C for 30 minutes Question 2 Marks: --/1 Benzyl alcohol is classified as: Choose one answer. a. Diluent b. Preservative c. Suspending agent d. Emulsifying agent Question 3 Marks: --/1 Bioavailability in ophthalmic solutions are usually at what percentage? Choose one answer. a. 15-20% b. 10-15% c. 1-3% d. 3-10% * * *

e. 20-30% Question 4 Marks: --/1 Death due to cyanide toxicity results from: Choose one answer. a. Inhibition of Cytochrome oxidase (respiratory enzyme) b. Coronary vessel embolism c. Cyanide hemoglobin complex formation d. Cyanide combining with the RBCs e. All of the above Question 5 Marks: --/1 Dissolution is affected by which of the following options? Choose one answer. a. All of these b. Temperature c. Viscosity d. None of these e. Surface area Question 6 Marks: --/1 Flu vaccinations are NOT generally recommended for which patient group? Choose one answer. a. Chronic renal failure. b. Patients who have diabetes. c. Chronic heart disease. d. Patients over 50 years old * * *

e. Patients with asthma or chronic respiratory disease. Question 7 Marks: --/1 In respects to carbidopa, which of the following is a correct statement? Choose one answer. a. Carbidopa decrease the plasma half-life of levodopa b. Carbidopa is a prodrug of serotonin c. Carbidopa crosses the Blood Brain Barrier d. Carbidopa inhibits DOPA carboxylase e. Carbidopa induces peripheral conversion of levodopa to dopamine Question 8 Marks: --/1 In respects to enteric coated tablets which of the following is true? Choose one answer. a. They are protected from gastric acid b. They are protected from moisture c. They do not dissolve in the gastric tract d. They are protected from the relatively alkaline e. They are cheaper to manufacture Question 9 Marks: --/1 Malaria is an infectious disease. It is NOT caused by which of the following organisms? Choose one answer. a. Plasmodium falciparum b. Plasmodium malariae c. Plasmodium ovale d. Plasmodium malicipare * * *

e. Plasmodium knowesli Question 10 Marks: --/1 Mr K presents at the pharmacy requesting various medications for his upcoming holiday. You know he has moderate renal impairment (creatinine clearance of less than 20ml/min). Which of the following drugs should he not be sold? Choose one answer. a. Chloroquine b. Loperamide c. Omeprazole d. Ibuprofen e. Domperidone Question 11 Marks: --/1 Mr. H is seeking advice about this wife, Mrs. H (aged 30). They have just returned to Australia from their holiday in Thailand and Mrs. H is complaining of a stiff inflamed lower leg. He says it is quite red and hot. She is not taking any medication except the oral contraceptive pill, What is the most appropriate advice? Choose one answer. a. make an appointment to see her GP b. sell aspirin for DVt prophylaxis c. seek medical help immediately * d. sell ibuprofen 400mg and tell her to take it regularly for five days e. recommend that she follows the RICE approach and seek further advice if no improvement after seven days Question 12 Marks: --/1 The following question concerns the chemical structures shown below: SPLIT Which of the following statement(s) is correct? * *

A Choose one answer. a. A is an immediate precursor of B.

b. A can cross the Blood Brian barrier whereas, B cannot c. A is excreted with greater ease and therefore does not stay in bioavailability for long enough d. A is metabolised faster than B and therefore cannot reach the bioavailability Question 13 Marks: --/1 Topical products for acne may contain benzoyl peroxide as a (an)... Choose one answer. a. Bactericidal b. Keratolytic c. Antimicrobial d. Retinoid e. Emollient Question 14 Marks: --/1 What dose of folic acid is used to prevent secondary recurrance of neural tube defects? Choose one answer. a. 5 milligrams b. 600 milligrams c. 400 milligrams d. 200 milligrams e. 2.5 milligrams Question 15 * *

Marks: --/1 What is the definition of acute agitation? Choose one answer. a. acute onset of impairment in consciousness and cognition associated with a medical/physical cause b. acquired global impairment of cognitive function c. state of anxiety accompanied by motor restlessness * d. excessive and uncontrollable worry e. behaviour leading to self assertion Question 16 Marks: --/1 What is the latin abbreviation before food? Choose one answer. a. ac b. rc c. cc d. pc e. dc Question 17 Marks: --/1 What type of reaction is illustrated below? " border="0" hspace="0" alt="?" vspace="0" src="http://apecexam.com/file.php?file= %2F4%2FReaction_Arrow.png" width="374" height="144" Choose one answer. a. Nucleophillic enentiomerisation b. Nucleophillic electophilisation c. Nucleophillic isomerisation *

d. Nucleophillic substitution e. Nucleophillic addition Question 18 Marks: --/1 Which of the following are Type I hypersensitivity reaction Choose one answer. a. Rheumatic fever b. Diabetes c. Poison ivy d. Asthma e. Myasthenia gravis Question 19 Marks: --/1 Which of the following is NOT a common symptom of Alzheimers? Choose one answer. a. Language decline b. Agression c. Memory loss d. Sensory decline e. Mood swings Question 20 Marks: --/1 Which of the following statements is incorrect? Choose one answer. a. vitamin B toxicity can cause to neurological symptoms b. zinc can aid the absorption of vitamin C c. vitamin D increases the uptake of calcium in the bones * * *

d. vitamin K has a synergistic effect on warfarin * e. excess retinol consumption should be avoided in pregnancy

http://apecexam.com/mod/quiz/attempt.php?q=2

1 Marks: --/1 A Doctor prescibes diazepam to a 80kg. It is to be given as 10mcg/kg/hr. You are given an infusion bag that contains 100ml of a 1 mg in 100ml solution. How long will the infusion last at the given dose? Choose one answer. a. 2.0 hours b. 1 hour c. 3.0 hours d. 1.5 hours e. 1.25 hours Question 2 Marks: --/1 A doctor wants to transfer a patient from 60mg bd morphine to the equivalent diamorphine dose do to hospitalisation, what dose do you recommend? Choose one answer. a. 18 mg bd b. 9 mg bd c. 9 mg od d. 0.9 g od e. 18 mg od * *

Question 3 Marks: --/1 A doctor wants to transfer a patient from 90 mg td morphine to the equivalent diamorphine dose due to hospitalisation, what dose do you recommend? Choose one answer. a. 18 mg od b. 27 mg od c. 27 mg bd d. 27 mg td e. 18 mg bd Question 4 Marks: --/1 A elderly lady is to recieve an infusion of insulin at a rate of 0.1 units/kg/hr. The syringe pump contains 50 units of insulin in 50ml of a standard saline solution. at what speed in ml/hr should the pump be set at for a lady weighing 80 kg? Choose one answer. a. 1 ml/hr b. 6 ml/hr c. 4 ml/hr d. 8 ml/hr e. 2 ml/hr Question 5 Marks: --/1 A patient is given the following reducing dose of prednisolone, what quantity of drug in grams will the receive over the duration of the treatment?: Take 15 x 5mg on day one to two Take 10 x 5mg on day three to four Take 8 x 2mg daily for the remainder of the first week Then take 8 x 1mg daily for the following 3 weeks (4 week duration in all). Choose one answer. * *

a. 0.469 g b. 0.345 g c. 0.444 g d. 0.456 g e. 0.466 g Question 6 Marks: --/1 A patient is on one fentanyl '75' patch what is the approximate equivalent diamorphine dose? Choose one answer. a. 89 mg b. 81 mg c. 72 mg d. 25 mg e. 55 mg Question 7 Marks: --/1 A standard infusion set delivers one drop as 0.05ml. A 400ml of fluid is to be given over two hours what is the drop rate per minute? ( to the nearest 10 drops) Choose one answer. a. 70 drops b. 40 drops c. 50 drops d. 60 drops e. 90 drops Question 8 Marks: --/1 A standard infusion set delivers one drop as 0.1ml. A 300ml of fluid is to be given over * * *

three hours what is the drop rate per minute? ( to the nearest 10 drops) Choose one answer. a. 40 drops b. 10 drops c. 30 drops d. 50 drops e. 20 drops Question 9 Marks: --/1 Convert 1 mcg/minute to mg/day? Choose one answer. a. 1.44 mg/day b. 1.66 mg/day c. 1.22 mg/day d. 1.00 mg/day e. 2.00 mg/day Question 10 Marks: --/1 Give approximate amounts of potassium ions in 0.5 L of secretion in the small bowel. Choose one answer. a. 50-100 mM b. 2.5-7.5 mM c. 0-2.5 mM d. 7.5-15 mM e. 15-45 mM Question 11 Marks: --/1 * * *

How much potassium chloride is there in a 250 ml infusion of an 8.4% w/v solution? Choose one answer. a. 14.5 g b. 12.3 g c. 16.8 g d. 21.0 g e. 8.61 g Question 12 Marks: --/1 How much sodium chloride is there in a 200 ml infusion of an 8.4% w/v solution? Choose one answer. a. 12.3 g b. 8.61 g c. 16.8 g d. 29.3 g e. 14.5 g Question 13 Marks: --/1 How much sodium chloride is there in a 300 ml infusion of an 23.4% w/v solution? Choose one answer. a. 12.61 g b. 35.8 g c. 22.3 g d. 70.2 g e. 32.5 g Question 14 Marks: --/1 * * *

A prescription for 60 tablets of 60mg morphine tablets is received. You are charged with creating the tablets from scratch as the patient has allergies to all excipients in commercially available preparations. The formulation is as follows: 60mg morphine sulphate 2mg magnesium stearate Make up to 150mg with cellulose When the cellulose dries out after the tablet has been stored the anyhrdous version of cellulose will be 15% less in mass. What will the resulting mass of the tablet be after storage? Choose one answer. a. 126.8 mg b. 93.6 mg c. 8.2 g d. 116.2 mg e. 101.28 mg Question 15 Marks: --/1 The volume of distribution (Vd) is defined as (bioavailability x salt fraction x dose) divided by the concentration. If the bioavailability is 1 the dose is 4g, the salt fraction is 2 and the concentration is 2mg/L what is the Vd? Choose one answer. a. 50 L b. 100 L c. 1000 L d. 4000 L e. 200 L Question 16 Marks: --/1 What weight of base (diluent) do you require to make 10 x 2.2g 7.5 %w/w clotrimazole suppositories? * *

Choose one answer. a. 20.35 g b. 21 g c. 20.55 g d. 20.65 g e. 33.66 g Question 17 Marks: --/1 You are trying to work out your BMI, you weigh 63kg and are 5 foot 8 inches what is your approximate BMI? Choose one answer. a. 29 b. 22 c. 27 d. 26 e. 20 Question 18 Marks: --/1 You have a 0.5% nubuliser solution of salmeterol. What volume of the solution is required for a 5mg dose? Choose one answer. a. 2.5 ml b. 0.5 ml c. 1.5 ml d. 1 ml e. 2.5ml f. 2.0 ml Question 19 * * *

Marks: --/1 You need to give 250mg amoxicillin tds orally each day over a period of a month. You can only order 100ml, 125/5ml bottles, what is the most cost effective approach, how many bottles would you order? Choose one answer. a. 9 b. 8 c. 12 d. 16 e. 15 Question 20 Marks: --/1 You need to give 1g amoxicillin orally each day over a period of a week. You have 250/5ml how much suspension do you need for 4 days? Choose one answer. a. 0.06 L b. 30 ml c. 0.06 ml d. 80 ml e. 0.6 L * *