SWISS-PROT: P41047 ID AC DT DT DT DE GN OS OC OC RN RP RX RA RA RL RN RP RC RX RA RL RN RP RX RA RA RL RN RP RX RA RA RL CC CC CC CC CC CC CC CC CC CC CC CC CC CC DR DR DR DR DR DR KW KW FT FT FASL_MOUSE STANDARD; PRT; 279 AA. P41047; 01-FEB-1995 (REL. 31, CREATED) 01-FEB-1995 (REL.

31, LAST SEQUENCE UPDATE) 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE) FAS ANTIGEN LIGAND. FASL. MUS MUSCULUS (MOUSE). EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; EUTHERIA; RODENTIA. [1] SEQUENCE FROM N.A. MEDLINE; 94185175. [MEDLINE, MEDLARS] TAKAHASHI T., TANAKA M., BRANNAN C.I., JENKINS N.A., COPELAND N.G., SUDA T., NAGATA S.; CELL 76:969-976(1994). [2] SEQUENCE FROM N.A., AND 3D-STRUCTURE MODELLING. STRAIN=C57BL/6; MEDLINE; 95388076. [MEDLINE, MEDLARS] PEITSCH M.J., TSCHOPP J.J.; MOL. IMMUNOL. 32:761-772(1995). [3] SEQUENCE FROM N.A. MEDLINE; 95196085. [MEDLINE, MEDLARS] LYNCH D.H., WATSON M.L., ALDERSON M.R., BAUM P.R., MILLER R.E., TOUGH T., GIBSON M., DAVIS-SMITH T., SMITH C.A., HUNTER K.; IMMUNITY 1:131-136(1994). [4] CHARACTERIZATION OF VARIANT GLD. MEDLINE; 96091792. [MEDLINE, MEDLARS] HAHNE M., PEITSCH M.C., IRMLER M., SCHROETER M., LOWIN B., ROUSSEAU M., BRON C., RENNO T., FRENCH L., TSCHOPP J.; INT. IMMUNOL. 7:1381-1386(1995). -!- FUNCTION: CYTOKINE THAT BINDS TO FAS ANTIGEN, A RECEPTOR THAT TRANSDUCES THE APOPTOTIC SIGNAL INTO CELLS. MAY BE INVOLVED IN CYTOTOXYC T CELL MEDIATED APOPTOSIS AND IN T CELL DEVELOPMENT. FAS-ANTIGEN MEDIATED APOPTOSIS MAY HAVE A ROLE IN THE INDUCTION OF PERIPHERAL TOLERANCE, IN THE ANTIGEN-STIMULATED SUICIDE OF MATURE T CELLS, OR BOTH. -!- SUBUNIT: HOMOTRIMER (PROBABLE). -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN. MAY BE RELEASED INTO THE EXTRACELLLULAR FLUID, PROBABLY BY CLEAVAGE FORM THE CELL SURFACE. -!- DISEASE: A DEFICIENCY IN THIS PROTEIN IS THE CAUSE OF GENERALIZED LYMPHOPROLIFERATION DISEASE (GLD), AN AUTOSOMAL RECESSIVE DISEASE RESPONSIBLE FOR LYMPHADENOPATHY AND AUTOANTIBODY PRODUCTION. -!- SIMILARITY: BELONGS TO THE TUMOR NECROSIS FACTOR FAMILY. EMBL; U06948; G473565; -. [EMBL / GenBank / DDBJ] EMBL; U10984; G511222; -. [EMBL / GenBank / DDBJ] EMBL; S76752; G913760; -. [EMBL / GenBank / DDBJ] PROSITE; PS00251; TNF. PRODOM [Domain structure / List of seq. sharing at least 1 domain] SWISS-2DPAGE; GET REGION ON 2D PAGE. CYTOKINE; TRANSMEMBRANE; GLYCOPROTEIN; SIGNAL-ANCHOR; APOPTOSIS; DISEASE MUTATION. DOMAIN 1 78 CYTOPLASMIC (POTENTIAL). TRANSMEM 79 100 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN).

FT FT FT FT FT FT FT FT FT FT SQ

DOMAIN DOMAIN DOMAIN DISULFID VARIANT CARBOHYD CARBOHYD CARBOHYD CARBOHYD SEQUENCE MQQPMNYPCP PLPLPPLTPL KVSSFEKQIA INETGLYFVY SYLGAVFNLT

EXTRACELLULAR (POTENTIAL). PRO-RICH. POLY-PRO. BY SIMILARITY. F -> L (IN GLD; ABOLISH BIDING OF FASL TO ITS RECEPTOR). 117 117 POTENTIAL. 182 182 POTENTIAL. 248 248 POTENTIAL. 258 258 POTENTIAL. 279 AA; 31442 MW; AFD84D4B CRC32; QIFWVDSSAT SSWAPPGSVF PCPSCGPRGP DQRRPPPPPP PVSPLPPPSQ KKKDHNTNLW LPVVFFMVLV ALVGMGLGMY QLFHLQKELA ELREFTNQSL NPSTPSEKKE PRSVAHLTGN PHSRSIPLEW EDTYGTALIS GVKYKKGGLV SKVYFRGQSC NNQPLNHKVY MRNSKYPEDL VLMEEKRLNY CTTGQIWAHS SADHLYVNIS QLSLINFEES KTFFGLYKL

100 4 45 200 273

279 69 51 231 273

// ---------------------------------------------------------------------------[Model] Direct Swiss-Model submission [Image] Direct BLAST submission: at GBRI or at NCBI (Bethesda, USA) [Image] Sequence analysis tools: ProtParam, ProtScale [Image] Manuel C. Peitsch