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  • On The Other Hand

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    cestlavie14
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    The HeLa cell line is one of the best known and most used cell models in vitro. Cells lack a functional p53 due to a papillomavirus 16 infection. This renders them insensitive to apoptosis induced by many conventional chemotherapeutic drugs.

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    On the Other Hand

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    The HeLa cell line is one of the best known and most used cell models in vitro. Cells lack a functional p53 due to a papillomavirus 16 infection. This renders them insensitive to apoptosis induced by many conventional chemotherapeutic drugs.

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    10 visualizzazioni1 pagina

    On The Other Hand

    Caricato da

    cestlavie14
    The HeLa cell line is one of the best known and most used cell models in vitro. Cells lack a functional p53 due to a papillomavirus 16 infection. This renders them insensitive to apoptosis induced by many conventional chemotherapeutic drugs.

    Copyright:

    Attribution Non-Commercial (BY-NC)
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    Segnala contenuti inappropriati
    di 1

    On the other hand, cell cultures are an important tool to analyze the precise action mechanism of chemotherapeutic drugs.

    In this sense, the HeLa cell line (established from a human cervix carcinoma) is one of the best known and most used cell models in vitro. HeLa cells lack a functional p53 due to a papillomavirus 16 infection, which encodes the oncoprotein E6 responsible of p53 degradation via the ubiquitin in proteasome, thus rendering them insensitive to apoptosis induced by many conventional chemotherapeutic agents.

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