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Metabolism of Amino Acids-2

Degradation of Amino Acids


Faisal Khatib MD; PhD Faculty of Medicine, University of Jordan

Fate of the Carbon Skeleton of Amino Acids

Glucose

Degradation of Amino Acids

C4 Family

C5 Family AA that form glutamate

Arginase

Aminotransferase

C5 Family AA that form glutamate

C3 Family AA that form pyruvate


Tryptophan Glycine

Pyruvate

Amino Acids that Form Fumarate

Methionine
Isoleucine Valine

Amino Acids that Form Succinyl CoA

Succinyl CoA

TRANSAMINATION
Branched Chain amino acid aminotransferase

DEHYDROGENATION
OXIDATIVE DECARBOXYLATION

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Methionine

ATP

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S-Adenosylhomocysteine

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Homocysteine

B12

Adenosine

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B6

Folic Acid: Carrier of one carbon units

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Vit
B12

Vit B12

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Formate Histidine Glycine Serine

One Carbon units pool


Purines Methionine Thymidine

TetraHydroFolate is the Active Form (THF)


Folate

Dihydrofolate

Tetrahydrofolate

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Methionine
Isoleucine Valine

Amino Acids that Form Succinyl CoA

Succinyl CoA

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