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  • HUMAN HERPES VIRUS Types 6

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    80% of adults are sero(+) for HHV 6 infection frequently develops in infancy as maternal Ab wanes. HHV type 8 Isolated in 1994 and 1995 in tissues from kaposi's sarcoma (KS) and body cavity-based lymphoma in AIDS patients.

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    80% of adults are sero(+) for HHV 6 infection frequently develops in infancy as maternal Ab wanes. HHV type 8 Isolated in 1994 and 1995 in tissues from kaposi's sarcoma (KS) and body cavity-based lymphoma in AIDS patients.

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    HUMAN HERPES VIRUS Types 6

    Caricato da

    api-3704562
    80% of adults are sero(+) for HHV 6 infection frequently develops in infancy as maternal Ab wanes. HHV type 8 Isolated in 1994 and 1995 in tissues from kaposi's sarcoma (KS) and body cavity-based lymphoma in AIDS patients.

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    HUMAN HERPES VIRUS types 6, 7, & 8 Chapter 166 page 1052

    HHV type 6 HHV type 7 HHV type 8


    Isolated in 1986 from peripheral blood Isolated in 1990 from peripheral blood T- Isolated in 1994 & 1995 in tissues from
    leukocytes of persons w/ lymphocytes of a healthy 26 y/o man kaposi’s sarcoma (KS) & body cavity-
    lymphoproliferative disorders based lymphoma in AIDS patients
    ♥ Aka KS-associated herpesvirus
    (KSHV)
    Worldwide distribution more common in central & southern Africa
    80% of adults are sero(+) for HHV 6 concurrent epidemics of HIV-1 & HHV-8 in
    homosecual & bisexual men
    • Infection frequently develops in Infection frequently acquired during • Infects certain B lymphocytes &
    infancy as maternal Ab wanes childhood endothelium-derived spindle cells
    • Congenital infections (mostly due to • Also related to:
    HHV-6B) -AIDS-related B-cell body-cavity-based
    lymphomas &
    -multicentric Castleman’s dse
    (a lymphoproliferative B cell disorder)
    INFANTS & CHILDREN: • No human dse had yet been IMMUNOCOMPETENT
    • Examthen subitum (roseola definitively linked to HHV-7 although • Asymptomatic infection
    infanticum) – fever w/ subsequent the ff diseases are associated:
    rash ♥ Exanthema subitum IMMUNOCOMPROMISED
    • Febrile seizures w/o rash ♥ Childhood febrile illness • Neoplastic disorders
    OLDER AGE GROUPS: ♥ Neurologic syndromes
    • Mononcleosis syndromes (encephalitis, flaccid
    • Focal encephalitis paralysis)
    IMMUNOCOMPROMISED: ♥ Pityriasis rosea
    • Pneumonitis
    • Disseminated dse
    TRANSPLANT RECIPIENTS:
    • Graft dysfunction

    *implicated in Multiple sclerosis – further


    study needed
    MOT: saliva, genital secretions Commonly present in saliva of healthy Saliva, organ transplantation, IV drug use
    adults
    Now has 2 genetically distinct variants:
    HHV-6A and HHV-6B
    Susceptible to Ganciclovir & foscarnet Susceptible to Ganciclovir & foscarnet Susceptible to Ganciclovir, foscarnet &
    *clinical evidence is lacking *clinical evidence is lacking cidofovir
    *clinical evidence is lacking
    Antiretroviral therapy for HIV (+)
    individuals led to ↓ KS among individuals
    dually infected w/ HHV-8 & HIV
    HHV-6, HHV-7 & CMV infections may cluster in transplant recipients, thus it is difficult
    to sort out the roles of the various agents in individual clinical syndromes.

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