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Use of immunomodulatory therapy in children with pyoinflammatory diseases
S.V. Minayev, R.A. Motorina, S.V. Timofeyev


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The addition of licopid to the complex therapy of children with the local form of acute hematogenic osteomyelitis allowed their earlier
(by an average of 60.5 days fewer) activation, body temperature normalization, reductions in ESR and leukocytosis, and blood count
normalization. The use of licopid caused a treatment time reduction. The significant decrease in the blood levels of proinflammatory
cytokines (tumor necrosis factor-, interleukin-1) and C-reactive protein suggested that the intensity of the inflammatory process
became less. Furthermore, a rapider healing of postoperative wounds was noted in licopid-treated children with pyoinflammatory
diseases of soft tissues, which reduced the duration of antibacterial therapy by an average of 5 days. Treatment with licopid decreased
the frequency of septic complications by 2,7 times (from 50 to 18,75%) and mortality rates by 2,4 times (from 15 to 6,25%).
Key words: children, pyoinflammatory diseases, licopid.

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