TYPES OF HYPERSENSITIVITY

TYPE I:IgE Mediated

TYPE II: Cytotoxic & Cytolysis

TYPE III: Immune Complex

TYPE IV: Delayed Hypersensitivity

Antigen: exogenous pollen, Food, drugs, dust

cell surface of RBC basement membrane

extracellular fungal, viral, bacterial

intracellular or extracellular

Antibody Involved:

IgE

IgG, IgM

IgG, IgM

none

Complement Involved:

no

Frequently

Yes

no

Mediators Of injury: - histamine - mast cells - leukotrienes - prostaglandins

- complement lysis - macrophages in tissues

- neutrophils - complement lysis

- cytokines - T cytotoxic cells - Monocytes/ macrophages - lysosomal enyme

Examples: -Allergic rhinitis - Asthma

-Transfusion rxn - Goodpasture Syndrome - Autoimmune Thrombocytopenic purpura - Graves dses.

- SLE - RA

- Contact dermatitis to poison ivy

Skin Test: wheal & flare

none

erythema & Edema in 3-8 hrs.

eythema & edema in 24-48 hrs. (eg. TB test)