Pathophysiology of BREAST CANCER

Predisposing factor Gender M<F Genetic/Hereditary

Cell death = Cell replace

Response with carcinogen Damage/Change in genetic material [DNA]

Precipitating factor Life style Sexual practice Virus Environmental Chemical Physical

Hyperplasia Recurrent injury metaplasia Prolonged injury Mutation Loss of P53 Loss of apoptysis Dysplasia anaplasia Decreased T-CELL Neoplasia Promotion CANCER 1cm growth Angio genesis growth factor BREAST Lump Tail of Spence Orange peel dumpling Nipple inversion

Absorb Surrounding Nutrients

Cell starvation Hypothalamus

Lipolysis

Fat loss Weakness

Weight loss

Anorexia
Wasting syndrome

Cachexia

Hypoxia Lactic acid Pain

Anoxia Cell Death

Inflammation kinis PAIN Pyrogen Recurrent fever