Actin Reorganisation

Focal Adhesion Turnover

Cell Survival

Permeabiliby

Migration PGI2 production Proliferation

VEGF
Mini-Catalog VEGF Signaling Pathway

Vascular endothelial growth factor (VEGF) is a major regulator of new blood vessel growth and an important inducer of vascular permeability. VEGF binds the receptor VEGFR2 leading to a cascade of different signaling pathways, which result in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. VEGF is expressed in virtually all cells in the body and is such a potent regulator of

vascular development that its dosage must be tightly regulated. Disruption of a single allele of the VEGF gene in mice results in embryonic lethality due to severe vascular defects. A variety of physiological and pathological processes are associated with upregulation of components of the VEGF/VEGFR-system, including embryogenesis, the female reproductive cycle, pregnancy, wound healing, tumor growth, diabetic retinopathy and ischemic diseases.

Function
Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. CASP9 is processed by the caspase APAF1 and this step is thought to be one of the earliest in the caspase activation cascade.

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Function
This protein belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. Defects in HRAS are a cause of cancer. The antibody specifically recognizes HRAS and does not bind NRAS or KRAS.