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MECHANI SM OF ACTION
The drug passes unchanged into the colon where bacteria break it down to organic acids that increase the osmotic pressure in the colon and slightly acidify the colonic contents, resulting in an increase in stool water content, stool softening, laxative action. This also results in migration of blood ammonia into the
INDICATIO NS
Treatment of constipation. Prevention and treatment of portalsystemic encephalopat hy.
CONTRAINDICATION S
Contraindicated with allergy to lactulose, lowgalactose diet. Use cautiously with diabetes, pregnancy, and lactation.
SIDE EFFECTS
Abdominal fullness, flatulence, belching.
ADVERSE REACTIONS
GI Transient flatulence, distention, intestinal cramps, belching, diarrhea, nausea. Other Acid-base imbalances
REMARKS