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Cushing syndrome

Moon face Plethoric face

Buffalo hump

Abdominal obesity

Moon face
1)-Salt & water retention due to mineralocorticoid action of cortisol 2)- Fat mobilization from the lower part of the body

Hirsutism

Moon , plethoric face Acne, hirsutism Buffalo hump Abdominal obesity Abdominal striae Thin limbs Hypertension Hyperglycemia Polythycemia Lymphopenia

Hypothalamic pituitary-adrenal axis

Primary
Pituitary

Secondary
Hypothalamic

CRH

ACTH

Cortisol

Abdominal striae

Cause:
Rupture of subdermal capillaries due to stretch of thin skin over the abdominal obesity

Addisons disease

Melanin pigmentation Cause:


Increased secretion of ACTH & MSH due to loss of the negative feedback effect of cortisol

Sites of melanin pigmentation:


1)- Mucous membrane of lips &gums 2)- Skin ( pressure areas, aerola of the nipple) 3)- recent scars

Latent tetany

Trousseaus signs

Chovsteks sign

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