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GENERIC NAME None
BRAND NAME Atropine
CLASS Anticholinergic agent
Parasympatholytic; Inhibits action of
acetylcholine at postganglionic
MECHANISM OF ACTION parasympathetic neuroeffector sites.
Increases HR in life threatening
bradyarrhythmias.
Hemodynamically unstable Bradycardia,
Asystole, Bradycardic (<60 beats a
INDICATIONS minute) PEA, Organophosphate
poisoning, bronchospastic pulmonary
disorders.
Tachycardia, Hypersensitivity, unstable
cardiovascular status in acute
CONTRAINDICATIONS
hemorrhage and myocardial ischemia,
narrow-angle glaucoma.
Headache, dizziness, Palpitations, N/V,
Tachycardia, arrhythmias, anticholinergic
effects (blurred vision, dry mouth, urinary
ADVERSE REACTIONS
retention), paradoxical Bradycardia when
pushed slowly or at low doses, flushed,
hot, dry skin.
Pregnancy category C, Moderate doses
NOTES ON ADMINISTRATION
may cause pupil dilation.
Potential adverse effects when
administered with digoxin, cholinergics,
INCOMPATABILITIES/DRUG physostigmine. Effects enhanced by
INTERACTIONS antihistamines, procainamide, quinidine,
antipsychotics, benzodiazepines, and
antidepressants.
DOSE/ROUTE; Adult,Asystole 1mg IV/IO push may repeat every 3-5
and Bradycardic PEA minutes up to 3 doses.
DOSE/ROUTE, ADULT, 0.5 mg IV/IO every 3-5 minutes not to
Unstable Bradycardia exceed 3mg total.
DOSE/ROUTE, ADULT,
Extremely large doses (2-4mg or higher)
Organophosphate Poisoning
0.02 mg/kg IV/IO push. May double for
DOSE/ROUTE,PEDEATRIC second dose. Minimum single dose is 0.1
mg.
0.02 mg/kg IV/IO push. May double for
DOSE/ROUTEChild second dose. Maximum single dose in
child is 0.5mg. Max total dose is 1mg
DOSE, Adolescent single dose 1mg and total dose 2mg.
ONSET OF ACTION Immediate
PEAK EFFECTS Rapid to 1-2 minutes
DURATION OF ACTION Duration 2-6 hours
AZ DRUG BOX SUPPLY (4)prefilled 1mg syringes. Total 4mg
RANGE (1)8mg Multidose vial.
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