Types of blood disorder Platelet & non-plateletIt’s importance * Acquired bleeding disorders are varied and occur more frequently than inherited disorders. Common ones include multiple factor deficiencies caused by liver disease or vitamin K deficiency (since many coagulation factors are produced in the liver and several are vitamin K dependent) and factor inhibitors (especially factor VIII inhibitor, an antibody against factor Vill). .Schematic gram of the Coagulation System INTRINSIC EXTRINSIC Contact surface Cellular breakdown [xi] y+» tla Platelet Tissue phospholipid | thromboplastin PK) [HMWE x | xt «ea Vill) | ——— se 2 —Y + ix} —* Twix VIIA PB Cav] <-[_Carpra-viia_ |<" {vii) a =Y: | v Y ex cl * Heparin + AT it Inhibition