c


   

   







 

Y Indicate to which branch of the immune system the following statements appluy, using
H for humoral branch and CM for the cell mediated branch. Some statements may apply
to both branches.

a.Y involves class I MHC molecules.
b.  responds to viral infections.
c.   involves T helpers cells.
d.  CM involves processed antigen.
e.  most likely responds following an organ transplant.
f.  involves T cytotoxic cells.
g.  involves B cells.
h.  involves T cells.
i.  responds to extracellular bacterial infections.
j.  involves secreted antibody.
k.  kills virus-infected self-cells.

 compare and contrast the four types of antigen-binding molecules used by the immune
system: antibodies, T-cell receptors, class I MHC molecules, and class II MHC molecules,
in terms of the following characteristics:

antibodies T-cell Class I MHC Class II MHC

receptors
Specificity for *high degree of specificity The specificity Bind to a Bind to a
antigen *antibody combining site of the TCR is spectrum of spectrum of
reacts with more than one determined by antigenic antigenic
antigenic determinant ͞cross the peptides peptides
reactivity͟ combination
*distinguish between of ɲ and ɴ
primary structure of an chains.
antigen, isomeric forms and
secondary and tertiary
structures of an antigen.
Cellular Secreted by plasma cells CD4 and CD8 All nucleated Antigen-
expression lymphocytes. cells presenting
cells
Types of `Y D


 Processed Small Small
antigen 


 antigen antigenic antigenic
recognized   molecules peptides from peptides
  (associated the from the

  with MHC degradation degradation
 

 molecules) of foreign of foreign


Y protein protein
`Y  Y antigen. antigen.
`Y D

 Y
`Y x
Y
`Y x 
 

Y

·ive examples of mild and severe consequences of immune dysfunction. What is the most
common cause of immunodeficiency throughout the world today?

Mild immune dysfunction: allergy and asthma

Severe immune dysfunction: autoimmune disease (Crohn͛s disease, multiple sclerosis,

rheumatioid arthritis͙), immunodeficiency (SCID, lack of IgA, AIDS͙)

The most common cause of immunodeficiency worldwide is caused by HIV, the syndrome
known as AIDS.