Reference guide for Pharmaceutical calculations ‘Krisman Second Edition 7 7 REFERENCE GUIDE FOR PHARMACEUTICAL CALCULATIONS SECOND EDITION 2002 - 2003 MANAN SHROFE www:pharmacyexam.com 1Refetenice guide for Pharmaceutical calculations : Krisman - Second Edition . « This reference guide is not intended a a substitute for the advice Of a physician: Students or readers must consult their physician about nty existing problem. Do not use any information of, this reference guide for any kind of self treathient, Do not administer any dose of mentioned drugs in this reference guide without consulitig your physician. This is onby'a review guide for” preparation of pharmaceutical calculations. ‘The author of this reference guide is not responsible for any kind of misinterpreted, incorrect or misleading information or any typographical errors jn.this guide. Any doubsful or questionable answers should be checked in other available reference sources. 2 All rights reserved. No part of this guide may be reproduced of transmitted in any form or by any means, clectroni- cally photocopying, recording or otherwise, without prior written permission of the publisher. RXEXAMG® is a registered trademark.of Pharmacy Exam of unauthorized use of this trade mark wil be considered a viola hnd Publication ine. Arty ‘of law: [NAPLEX® and FPOBED exam ae federally episod tademark owned by Nationl Asiocation Boar of Pharmacy (NABP).ETCB it ‘be teak oaedy Pay Tn Corin Do evio pldosin no way authried or sponsred by NABP orPTCB, \wwrw.pharmacyexam.comReference guide for Pharmaceutical calculations Sate Second Edition PREFACE Reference guide for Pharmaceutical calculations is a resourceful practice guide for preparation of the NAPLEX®, FPGEE® , California Pharmacy Board Exam and PTCB@ exams, It contains more than 400 calculation problems to prepare students to tackle an actual exam. NAPLEX®, FPGEE®, California Pharmacy Board Exam and PTCB® exams are currently putting more emphasis on calculation problems. 25 % to 30% of NAPLEX®, FPGEE®, California Pharmacy Board Exam and PTCB® exams consist of calculations. Calculations related to LV,, IV. infusion, TPN and dosages are very important in retail and institutional pharmacy settings. This guide will provide complete practice on related calculation problems and help to achieve an exceptional score on the examinations. Best of luck, Manan Shroff www>pharmacyexam.com 3Reference guide for Pharmaceutical calculations Second Edition TABLE OF CONTENTS SECTION - I 1. CALCULATIONS 1 2. ANSWERS 36 SECTION - I 1. PRACTICECALCULATIONS © 72 2. ANSWERS 195 swwwipharmacyekam.com Krisman0.001 milligrams (weight in Ibs / 150) x adult dose ~ (body surface area of child / 173 mm?) x adult dose (age in months / 150) x adult dose = 10° grams = 10° grams i 65 milligrams = 1000 ce ounce (oz) = Wee 16 ounce (02) = 480ce = Lpint 1 pint = 480 cc 1 quart = 960ce = 2pints 1 gallon = .3840ce 8 = Spits = 4quarts 1kg = 22 Ibs 1b = 454 grams 1 teaspoonful = Sec Ltablespoonfil = = 15 1 teacupful 120 ec Density a weight/volume Proof gallon = (gal x % v/v strength) / 50% v/v 9% strength = proof spirit /2 Proof gal = gal x proof spirit) / 100 PV = aRE PV = WMxRxT Equivalent we = molecular weight / number of valence mEq = equivalent weight in mg / 1000 ‘mOsmoV/L. = (Weight of substance [g/L] x no of species x 1000) / mol we] pH = pKa + log (salt/acid) ‘Young (child) = (agein years /age +12) x adult dose FP of blood 052°C Each gm of hydrous dextrose provides = 3.4 calories / kcal Each gm of anhydroys dextrose provides 4 calories / keal Each gm of fat provides 9 calories /keal Each gm of protein/aminoacid provides 4 calories / kcal Each gm of medium chain triglyceride (met)= 8,3 calories / kcal Each gm of glycerol provides 433 calories /Keal Each ec of alcohol provides 5.6 calories / kcal 1 ce of 10% fat emulsion provides 1 co of 20% fat emulsion provides 1.1L ealoties / keal 2.0 calories / keal wwwphamacyexam.com 5Reference guide for Pharmaceutical calculations Krisman 52 Second Edition PRA Tog Galvacid) or Gonizedunionized) (or weak acid) 7 pKw - pKb + log (base/salt) (for weak base) B= 23xC Kax Ho (Van slyke’s buffer capacity equation) vo 0 0.576xC Acceleration gravity (g) t Gas constant (R) I calorie Avogrado’s number K = 2,303 log Co t i i 0.693/K, MIC, R, = Cssx VdxK CssxV, Normality (N): ‘Molarity (M): Molality (m): Ka+ HOF where C = total buffer concentration, H,0* = hydrogen ion concentration where C = total buffer concentration ‘Temperature conversion: (maximum buffer capacity) 980 emi/sec? (0.082 lit atm / mole deg 4.184 x 10" erg 6.0221 x 10 mole" where t,, = half life of drug where K’= rate constant where V, = volume of distribution where M = amount of drug in body where C, = plasma concentration of drug where R, = sate of infusion where Css = steady state plasma concentration where Vd = volume of distribution where K = drug elimination constant where L, = loading dose of drug steady state plasma concentration volume of distribution Itis defined as the presence of riumber of gram equivalent weight of solute in 1000 ml or (IL) sohition.. Ikis defined as the presence of number of moles of solute i 1000 ml or (IL) of solution." Ikis defined asthe preschoe of aun ot moles ot solute in 1000 gm of solvent, 23! 90C) = 5CF)-160 vewwpharmacyexam.comReference guide for Pharmaceutical calculations oKrisindiy Second Edition tains? QUESTIONS eet ‘www-pharmacyexam.comReference guide for Pharmaceutical calculations Second Edition 1, ‘Sulfar 3% Salicylic acid 3% ‘White Petrolatum.. ys. 80 gm Find out the amount of Sulfur required to fill the above prescription? a 12gm b. 24gm c 3.0gm 4 48sm 2. How many grams of Dextrose are re- quired to prepare 5% of 500 ce solution? a 25 em b 25m c 55m wo a Sem * é 3. How much Lidocaine is required to prepare 1 : 1000, 30 cc of solution of Lidocaine? a 10mg b. 0.03 mg c. 30mg 4 300mg 4. How many milligrams are equal to 1/150 ge of Nitroglycerine? a 150 mg ’. 65mg c 55mg da 043mg 5. How much Atropine is required to dis- pense 1 quart of 1 in 100 solution? a 9.6mg db. 1.48gm c 23mg 9600 mg ‘www,pharmacyexam.com 6. Krisinan ts How many ce of 75% alcohol should be mixed with 10% of 1000 ce alcohol to pre~ pare 30% of 500 ce alcohol solution ? 7. 346.16 ce 234.43 cc 153.84 cc 121.12 cc How many grams of Heparin are re- quired to prepare 1 quart of 0.45% solution? 8. 2.16 gm 432m 0.45 gm 45 om ‘Ifaprescription reads “Augmentin 875 mg po bid x 10 days,” how many co of Aug- rientin 250 mg/5 cc are fequired to fill a ten-day supply? Bore a 350 ce 35 ec W5ce See 1£ 250 mg of Cefazolin powder are di- uted with water up to the 250 cc mark, what is the % of drug in the final solution ? ee ee 10. 10% 0.1% 11% 0.01% If 1 teaspoonful of Thioridazine con- centrated solution (30 mg/cc) is diluted up t6 the 480 co mark with plain water, what is the strength of drug in mg/ml in the final solution? spy Img/ee 0.52 mg/ceReference guide for Pharmaceutical calculations Second Edition c. 0.31 mg/ee 4. 0.75 mgiee Ui. If a prescription reads “Diphenhy- dramine 50 mg po hs x 30 days”, what would be the dispensed quantity of drug in ml (12.5 mg /5 cc) for thirty-day supply? a 20ce b. Sec c. — 300ce d. 600 ce 12. Erythromycin 2% 60 ce topical solu- tion contains: a. 2gmerythromycin, b. 2.4 gmerythromycin ¢. 0.6 gmerythromyein a 1.2 gmerythromycin 13. 1f60mgof elementary ion are present in 325 mg of ferrous sulfate, what is the % of elementary iron? a. 20.00% b. 10.25% ce 18.46% ad 9.25% 14, If 60 gm of 1% hydrocortisone are mixed with 80 gm of 2.5% hydrocortisone, what is the % of hydrocortisone in the final mixture? a 2.2% whw b. 1.85% wiw cc. 0.25% wir da 1.75% wiw 45. Ifa prescription reads “100 meg cy- anocobalamin im. every week”, how many ampuls of 1000 meg / cc are required to fill a month supply? ‘www: pharmacyexam.com ‘Krisman, pose ewe 16. If 1000 tablets of Risperdal 1 mg cost $2250 and the mark-up on prescription is 20%, what would be the retail price for 30 tablets? a $150 b. $7 c $500 a $8l 17. How much Clobetasole is present in 60 gm of 0.5% ointment? a 12gm b. 3.0gm c 21gm 4 03gm 18. Ifthe ratio of ionized to unionized spe- cies of drugs is 10° and PKa=2.2, whatis the pH of the solution? a 22 b 08 Ceo a 30 19, _ Ifaprescription reads “Augmentin 875 img by mouth twice a day”, how many cc of Augmentin 400 mg/S cc are required to dis- pense a 10 day supply? a 10.93 ce b. 218.75 ce ce. — 75.00ce 4 — 100.00cc 20, Find out the weight in gm of 500 cc glycerine. [Specific gravity = 1.25 gm/ml]Reference guide for Pharmaceutical calculations Second Edition a 625m b. 50gm ce. 400gm ad 0.25 gm 21. Find out the volume of 5 Ib of glycer- ine. [density = 1.25 gm/ml] a 1816 ce b. 6.25ec ce. 637cc 4d 40ce 22, — Calculate the weight of 500 ce of acid. [density of acid = 2.5 gm/ml] a. 1000 gm bd. 1250gm ce. 500gm 4d 200gm 23. Find out the ratio of ionized to union- ized species of drugs at pH = 7. {pKa = 5] 10 1 100 1000 a b c a 24, If the pH of the solution is 3, what is the concentration of HO" in gm ion /L? a. 0.01 gavion/L, b. 1x10" gm-ion/t, . ©. 0.05 gm-ion/L, 4. 10° gmion/L. 25. Whatis the pH of a solution having a ratio of ionized to unionized species of drugs of Lx 106 )PKa=7] weww.pharmacyexam.com es Krisman, 26. How many 500 mg tablets of erythro- mycin are required to prepare 240 ce of 2% solution of erythromycin? a3 ies GO) a 10 27. How many milligrams are equal to 1 150 grains? a 065mg b 121mg c 043mg a4 156mg 28. How many 975 mg tablets of aspirin are required to prepare 100 tablets of 1 grain? a 6 tablets b. 10 tablets cS tablets d. 3 tablets 29, 163 capsules of 150 mg of Clindamy- cin are added to 150 ce of 1% Cleocin topical solution, what is the % of Clindamycin in the final mixture ? a 15% b 13% ce 11% da 0.9% 30. The adult dose of a drug is 500 mg. What is the dose for a2 year old child? fuse young rule] a 71.42 mg b. 101.53 mg ce. .25.46mg a 3118 mg 10 } iReference guide for Pharmaceutical calculations: Second Edition 31. eeoe 32. 35. pup oe ‘The adult dose of a drug is 750 mg, what is the dose for child weighing 20 Ibs? 100 mg 250mg 500 mg 425 mg If adropperis calibrated to deliver 325 mg of iron sulfate in 0.6 cc and an adult dose of drug is 325 mg, what is the dose of a drug in ce for a 15 month old infant? 12ce 0.3cc 0.06 ce. 0.01 ce Tf an adult dose of a drug is 100 mg, ‘what would be the dose for a child having a ‘body surface area of 20 mm? ? a: 5.51 mg bd -12.32 mg c. 20.60mg a 11.56mg 34, Howmany milligrams arin 10 grains ‘of aspirin? 81mg 60 mg, . 325mg 4 650mg If a normal dose of a drug is 10 mg/ g/day, how many 250 mg/100cc ready-infu- ‘Sion bags are required to fill the above order? [Patient's weight is 156 Ibs.] 1 bag 2bags 3 bags S bags www:pharmacyexam.com 36. Krisman If the prescription calls for “50 micro- grams of a drug three times daily for 10 days”, how many 1/100 grain tablets are required to fill the above order ? a Stablets b. 3 tablets ce. Ltablet dG tablets 37. Ifaprescription reads “Lanoxin 0.125 mg by mouth every day”, how many ce of Lan- oxin 50 megice are required to dispense a 30 day supply? a 7560. bv. —-50ce & — 100ce 4 240ce 38. Ifa prescription reads to dissolve 2 gm of guaifenesin in 100 ce of water, how many agains of guaifenesin are present in I tesspoon- ful of solution? a 1.53 grains bd. 2.61 grains c. 3.15 grains 44.20 grains 39. If 100 mg of Lactin is equal to 4500 units, how many milligrams are required to obtain 1 unit? a 2.22mg b. 002mg ce. 325mg a 450mg 40. Ifa prescription reads “Ampicillin 50 mg by mouth twice a day” for a 7 year old child, how many ce (125 mg/5 ce) are required to dispense a7 day supply of the drug? iReference guide for Pharmaceutical calculations Second Edition 150 ee 240-ce 28 ce 56 ce Rese 41. Whatis the dose of a drug fora person having 110 m? body surface area? The aver- age adult dose of the drug is 750 mg. a 1089mg b. 625mg c. 531mg a4 477mg 42. How many grams of a drug are re- quired to prepare 240 ce of 10% solution? a 12m b 36m 48gm 4 24gm 43. How many grams of sodium chloride are required to make 750 ce of 0.9% normal saline solution? a 135m b. 250m e675 gm a 12.25 gm 44. How many grams of dextrose are present in 500 ce of D,,W solution? a 50 grams >’. 125 grams c. 75 grams 4. 25 grams 45. How much Lidocaine is required to prepare 30 ce of 1:1000 solution? a 30mg bd. 0.03mg www-pharmacyexam.com Krisman ce 0,003 mg 4 300mg 46. How much Povidone-lodine is re- quired to prepare 1000 ce of 1 in 750 solu- tion? a 133. gm b. 3.12 gm e125 gm 4 0.95 gm 47. How many grams of dextrose are needed to prepare SL of 1 in 250 solution? a 7Sem b. 20m c. 80gm a4 Slgm 48. Whatis the % of boric acid in 1 in 20 solution? a 05% be 25% 5.0% d 15% 49, To dispense 5% of 250 cc solution of thioridazine, how many cc of 30 mg/ce are required? a -225¢c bv. :153¢e c Silee a 417 ce : 50. If 20 cc ofisperdal 1mg/oc are diluted ‘with water up o 240 ce mark-what would be the strength of drug in mg /ml? a. -2,2:mglee : b. Lmg/ec i cc. 0.1 mg fee aes? 0.08 mg/ee 2Reference guide for Pharmaceutical calculations Second Edition 51. How much 70% alcohol is required to prepare 750 ce of 20% alcohol? a. SOLO cc b. 335.16 ec ce. 2142806 a 428.12 cc 52. How much Atropine is required to pro- pare 3 quarts of 1 in 500 solution? a 221 gin b.-5.76gm c. 3.47 gm a 248m 53. How much Povidone-Iodine is re- quired to prepare 300 ce 10% solution? a 50gm b | Sem 10g 4 25gm 54, In what proportion should 5% of sali- cylic acid be mixed with 1000 grams of 1% salicylic acid to prepare 500 grams of 3% sali- cylic acid? a’ 250gm bv. 490m © 125 gm. ad 375 gm 55. How much atropine is required to pre- pare 240cc in such way that when 1 teaspoon- fal of the solution is diluted to 1 pint gives it 1 in 500 solution? a 225m b. 46.08 gm e 35.15 gm 4 2535 gm ‘wow.pharmacyexam.com 56. How many ampuls of compazine 5mg/ 2 cc ar required to prepare 2 quarts of 0.1% solution? a 125 b. 256 e384 a 4a 57. How many grams of 0.25% triamei- nolone ointment can be made from 2 grams of an active ingredient? a. 200gm b. 500gm c- 600'gm 4 800gm 58, How much sodium bicarbonate pow- det is required to prepare 240 ce of 0.10 N solution of sodium bicarbonate? = 84 em/mole) How many cc of concentrated HCL acid are required to prepare 500 ce of 0.05 N acid solution ? (molecular weight = 36.5 gm/mole, purity of HCl =37 % w/v, density = 1.2 gm/ce) a 10.11 ce b -3.35¢c ce. 2.05cc a 421c0 60. 1£60 grams of 2% hydrocortisone are mixed with 80 grams of 1% hydrocortisone, what would be the % of hydrocortisone w/w in final mixture? 13Reference guide for Pharmaceutical calculations Second Edition a, 321% b. | 142% c 421% a 5.76% G1. If 1 quart of 30% alcohol is mixed with 3 pints of 40% alcohol, what would be % of alcohol in w/v in the final mixture? 36.08% 42.18% 15.23% 8.15% Bese 62. In what proportion should 3% acetic, acid and 1% acetic acid be mixed to prepare 200 ce of 2.5% acetic acid? a. 150. and 50c¢ b. 100 and 100 ce ce. TS ccand 125 ec ad 175.cc and 25 ce 63, How many grams of 60% w/w HCl acid should be added to 500 gm of 40% w/w HICI acid to prepare 400 gm of 55% w/w HCL 250 gm 300 gm 100 gm 150 gm 64. How many cc of purified water should be added to 45% alcohol to prepare 750 cc (25% alcohol? a 125 ce bd. 222ce ©. 4:3338.¢c a 451cc 65, How many cc of D,,W solution should be mixed with D,W solution to get 700 ce of DW solution? www.pharmacyexam.com «Krisman a ice b. — 15lee e 5560 da 175ce 66. How much taxable alcohol is present in 1 quart of alcohol usp? a 1.25 gallons b. 2.31 gallons c. 0.56 gallons a 0.479 gallons 67. How many proof gallons are present in 1 pint 50% wiv alcohol? 0.10 gallons 0.51 gallons 2.30 gallons 0.125 gallons epee 68. How much diluted alcohol USP can be prepared from 1 pint of 0.5 proof gallon? 2 035 gallons b. . 3.25 gallons c. . 0.51 gallons 4. 4.21 gallons 69, How many proof gallons“are present in2 pints 10% alcohol? ; a 0.25 b. 0.05 ce. 0.45 ad 051 70. How much 95% alcobol can be pre- pared from 1 pint of alcohol labeled as 1/2 proof gallon? a 0.263 4 | iReference guide for Pharmaceutical calculations Second Edition b. 0.153 ce. 0.287 ad 0.351 71. How much boric acid is required to dispense 240 cc of a saturated solution? [solubility of boric acid is 1 gm/12 cc} a 20gms b. 10 gms e 1gm a 15 gms 72. A 250,000 IU vial of Abbokinase is reconstituted with 5 cc of sterile water for jection. If2 cc of this resultant solution is ine jected into 500 ce of 5% dextrose solution, ‘what is the final concentration of solution in units/ml? a 100 units/eo b. — 200units/ee cc. 350 units/ee a. 1250 units/oe 73. A prescription calls for Valproic acid 600mg by mouth three times a day for 10 days, how many cc of 250 mg/5 cc are required to fill the above prescription? a 120cce b 240 ce c 360ce a 480ce 74, — Bach tablet of Ibert contains 525 mg of ferrous sulfate, what is the % of elemen- tary iron in each tablet? (elementral iron = 105 a 10% b. 5% c. 15% 4. 20% {www pharmacyeram.com Krisman 75, Each ccof Ibert-500 liquid provide 25 mg of elementary iron, how many cc of Ibert- 500 are required to fill 105 mg of elementary iron? a 11200 b. 15¢c e 1Bee ad lee 76. The recommended dose of Nembutal sodium in pediatric patients is 4 mg/im/kg . How many ampuls of Nembutal Na (100 mg/ 2.c0) are required in a child weighing 50 Ibs? Be gP eae 77. Albuterol sulfate inhalation solution is available as 0.083% w/v. How many milli- grams of albuterol are required to prepare a 2.5 cc unit dose vial? a. 0.083 mg b, 2g ce. . 163mg ad 312mg 78. A prescription for Alomide reads as follows: Alomide 0.1% eye drop sig: 2 gtts ou qid x 30days, How many milligrams of Alomide are present in per day dose of the drug? (J drop=0.1ec) a 16mg b, .23mg ce 4tmg a 0.15mg 15Reference guide for Pharmaceutical calculations Second Edition 79. . Aquasol (Vitamin A) is available as '50,0001.U//ec. How many milligrams of vitamin A are present in 5 cc? [ 11.U. =0.3 meg of. vitamin] 75mg 150 mg 37.5 mg 22.2 mg pose 80. . How many milligrams of Lidocaine are present in 30 cc of 2% Lidocaine viscous solution? a 1000 mg b. 600mg cc. 2000mg ad 60mg 81. How many cc of Megace (40 mg/ec) oral solution are required to dispense a'800 mg dose? a 0ce b. 120cc c 20ce 4 60cc 82. If 2 grams of Videx pediatric powder are reconstituted with 200 cc of purified wa- ter, and 10 cc of this resultant solution are mixed with 200 ce of Maalox plus, what would be the strength of videx in mg/ec? a 10mg/ee dD. 0.05 mg/ee e — Smgfee ad 0.5 mglee 83. Ifa prescription for Cefzil reads “500 mg by mouth four times a day”, how many ce of Cefzil oral suspension (125 mg/5 cc) are required to fill a 7-day supply ? ‘www pharmacyexam.com » Krisman_ a 20 cc b. 80ee c 100 cc 4 560 84. How many ce of Niferex liquid (100 mg elementary iron/5 cc) are required to pro- vide 325 mg of ferrous sulfate? [20% elemen- tary iron is present in ferrous sulfate} a 3.25 ce b. 16.25ce c 819¢C 4. 923e¢ 85. In what proportion should 5% HCL acid be mixed with 20% of concentrated HCL to prepare 500 cc of 8% HCI? a 400ce b.— 100ce. c — 250ce ad 320cc 86. 1 gmofRocephin (mixed with 250 ce 0.9% NaCl) is administered via slow IV. in- fusion over 24 hours. If the LY. set delivers 20 drops/cc, what would be the rate of flow in drops/min? or vb. 347 ‘ 5.13 a& 421 87. If adult dose of heparin is‘5000 units, ‘what is the dose of drug in 2 patient havingia 123mm? body surface areagasiai 2 ss Ba a, 1212.30 units b. 2523.20 units f c. 3554.90 units gd $432.10 unitsReference guide for Pharmaceutical calculations Second Edition 88... Howmany milligrams of Lidocaine are present in 5 ce of 1% Lidocaine solution? a 125mg bmg c, 100mg a4 50mg 89. A prescription reads for Hurnulin N as follows; “10 U SQ in am and 20U SQin pm.” How many days will one vial of Humulin N (10 U/ cc, 10 cc) Last? a 15 days b. —_2.0days c. 4.25 days d 3.33 days 90. . How many grams of Acetic acid are required to prepare 250cc of 7% w/v solution ? a 7.0gm »’. 10.2 gm e175 em a 145gm 91. How many grams of Hydrocortisone are present in 60 grams of 0.05% Hydrocorti- sone cream? a 120mg >. 30mg c 60mg 4 90mg 92. The recommended adult dose of Mezlocillin is 250 meg/kg/day. How many milligrams of drug are required in patients weighing 155 Ibs? a 17.61 mg b. 1.13 mg ce. 21.410mg a 15.17mg ‘wwwipharmacyexam.com Krismai, 93. _ Howmany gramsofPovidone Iodine aé required to prepare 480 ce of 10 in 100 solu- tion? a 48gm ’. 30m c 16 gm a Bem 94, In what proportion should 5% dextrose solution be mixed with 25% dextrose solution to prepare 500 cc 18% dextrose solution? a. 305.55 ec b. 194.440 c. 275.12¢e a 333.15 ce 95, How many cc of Hydrochloric acid are required to prepare 750 cc of 0.25 NHC1? [density of HCL = 1.2 gm/ml, molecular weight = 36.5 gm/mole, purity of HC = 37% wh] a 10.12c€ b 23.20 ce ce 1541 cc d. 5.80 ce 96. Aluminium (AI*) has a géam atomic weight of 27. What is it’s mEq weight? 2 pegs eau 97. How many meq of Nat are present in 0.9% 250 ce normal saline solution? [Na* = 23, Cr =35.5] a. 23.12 meq b. 15.17 meq ce. 53.15meq ad 38.46meq iwe guide for Pharmaceutical calculations Edition 982-2Howmany meq of K* are present in 750 mg of aKCl capsule? [K*=39, Cl =35.5] a. 11.11 meq b. 13.21 meq ec. 10.06 meq a 14.71 meq 99. ‘How many meq of Mg’? are present in 50 cc of 20% magnesium sulfate solution? {molecular weight = 246 em] 101.52 meq a b. 41.25 meq c. 31.56 meq - & — 81.30meq 100. How many grams of CaCl, are re- quired to prepare a 480 ce solution that coh- tains 200 meq of Ca'?? [mw CaCl, = 111 gm mole] 212em 314gm 415 gm 1.1 gm pose 101. How many milliequivaients of Al+3 are present in aluminium chloride? [106.5 gm/ mole} : a 21.2meq ’. 46.7 meq c. 35.5meq a 80.9meq 102. How many milliequivalents of ferrous sulfate are present in 325 mg of ferrous sul: fate? [MW = 151.85 gm/mole] a 5.6meq b. 4.28 meq ce — 7.50meq 4 10.12 meq www>pharmacyexam.com Krisman 103, Howmany milliequivalentsof sodium are present in 50% 200cc of sodium bicarbonate solution? [MW = 84 gm/mole] a 1190.47 meq b. 960.52 meq ce. 321.15 meq 655.23 meq 104. How much KCl is required to prepare 1 quart of syrup that contains 5 meq of K* in each teaspoonful’? [MW = 74.5 gm/mole} a 71.52gm b. 101.23 gm ce. 231.20gm 4 89.90 gm 105. How many milliequivalents of Na‘ are present in a 10% 1 quart NaPO, solution? [molecular weight = 164 gm/mole] a. 1012.23 meq b, 1756.31 meq 960.23 meq a 480.15 meq 106. How many milliequivalents of Li* are present in a 300 mg capsule of Li,CO,? [MW = 74 gm/mole] a 10.1. meq b. 4.23 meq c. 8.10 meq a 5.98meq 107. Mr. X has the following chart fot his daily blood pressure: 4 Day Blood prinmmHg Jan 180 SreSect Jan 2 160 Jan3 170 18Reference guide for Phaimaceutical calculations ‘Second Edition Jan4 175 Jan 5 160 Jan 6 183 Jan7 187 ao oe 108. 110. All. ‘What is the mean blood pressure in mm Hg 2 175 182.11 165.12 173.57 If the probability of success in a Null hypothesis is 0.6, what would be the probabil- . ity of failure? a 03 vb 09 c 06 eee 04 109, What is the degree of freedom in a 2X3 contingency table in a Chi-Square test? boas ‘Whatis the “mode” or “median” of the following values? 120, 135, 140, 118, 175, 105, 115, 190 135 118 127.5 115 How many grams of cocoabutter are re- ured to dispense 12 suppositories of tannic acid each weighing 2 gm, and containing 400 mg of tannic acid? [DV of tannic acid= 0.9} = www pharmacyexam.com Krisman 21.23 gm 18.67 gm M.12gm 13.25 gm ae oP 112, How many grams of base are required to dispense 20 suppositories of boric acid each, ‘weighing 2.gm and containing 500 mg of boric acid? (DV of boric acid = 1.5] 33.34 gm 30,00 gm 40.00 gm 21.00 gm ee oe 113. follows: Prednisone 60 mg po qdx2days, Prednisone 50 mg po qd x 2 days, Prednisone 40 mg po qd x 2 days, Prednisone 30 mg po qd x 2 days, Prednisone 20 mg po qd x 2-days, Prednisone 10 mg po qd x 2 days, then DIC. ‘How many tablets of prednisone 10 mg are required to fill the above prescription? a 42 b 31 eeeaa ad 60 114, ‘A tapering dose for prednisone is as If the concentration of reactant M is half in a reaction that is third order in M, by ‘what factor will the rate of reaction change? a. U8 times b. U4times ce. times ad 4times 19Reference guide for Pharmacentical calculations Second Edition 115. What is the rate of constant after 90 minuies f the initial concentration of a drugis 500 mgfcc, and SO mgfce after 90 minutes? [first order kinetic] a. 0.051 min? b. 0,025 mint ce. 0.33 mint d. 0.86 min? 116. Whatis the half-life of a drug that has a rate of constant of 0.067 days"? [first order Kinetic] a 21.12 days b. 3.15 days a ce. 10.34days @ 35.13 days 117. Whatis the rate of constatof heparin in first order kinetic if 500 units/ec of hepatih remain in a solution after 10 days? © 7° Giitial concentration of heparin was"5000 ‘units/cc} - a 0.56 days" b. 1.23 days e 232days 2 sayy 4 023days: 118. How long will it take to decompose Janoxin to one half of its original concentra: tion? [Rate of constant K = 0.023 min'] a. 40.45 minutes b. 50,60 minutes c. 75,80 minutes 4. 30.13 minutes 119. If the concentration of reactant A is double in areaction thatis second order inA, by ‘what factor will the rate of reaction change? www-pharmacyexam.com Krisman a 2times b. 16 times c 4 times d 1/2 times 120, What is the half-life of a drug that is in second order if the initial concentration of ‘the drug was 0.002M? [Rate of constant K = 7 litet/mote min] a 50.15 minutes b. . 13.65 minutes c 42.12 minutes Be a. 71.42 mimutes 121. How long will it take to decompose radioactive radium to 10% from its initial con- centration of 100%? [K = 3x 10+ per month] 1.23 x 10° months 3.12 x 10° months 4.15 x 10° months 0.76 x 10* months pose 122, How long will it take to decompose ethyl acetate to half of its original value? The initial concentration of dug was 0.01M and 0.001M after 40 minutes. : a 132.10 minutes 2 >. 60.8 minutes 23.20 minutes ‘ 4 12.15 minntes 123. The radioactive iodine has a'degraded constant of 0.016 year*, How long will it take to decompose to 10% of its initial coticentra tion? [Assume the initial concentration 100%] : a -25.56years. - © b. 32.20 years 143.93 years d 15x 10° years 20 | | | | |Reference guide for Pharmaceutical calculations Second Edition 124, Whatis the apparent volume of distibu- tion of 0.25 mg lanoxin ifthe plasma concentra- tion of the dragiss 0.10 nanogram/ml? a 3.2x10"L bo -25x10L ce 12x10L ad 4x10L 125, Ifthe LV. dose of a drug is 25 mg/L.V. kg, what would be the plasma concentration of drug in a patient weighing 156 Ibs? An ap- parent volume of distribution of drug is 0.5 L/ kg. a. 0.049 mg/ml b. 1.25 mg/ml cc. 2.36 ing/ml 4.28 mg/ml 126. What is the plasma concentration of a drug after 12 hours if the elimination half-life of the drugis 3.62 hours? The initial plasma con- centration of the drug was SOmg/ec. a Smgjee b, 2S mglec c — 40mg/ee a 50:mgfee 127. What is the rate of infusion of pheny- toin ina patient that requires steady state plasma concentration of 20 meg/ml ? ‘The elimination half-life of phenytoin is 4 hours and an apparent volume of distribution is ISL. a 4085 mg/hr b. 51.975 mg/hr ce 70.19mgfar 4 123,20 mgfhr = 128. Whatwouldbe the loading dose ofa drug to achieve 2 20 meg/ml steady state plasma www.pharmacyexam.com Krismaii concentration ? The apparent volume of distribu- tion is 4.5L. 8 é 129, The rate of infusion of Rocephin is 20 mmg/hr. How long will it take to infuse 500 mg 1100 ce Rocephin? a. 10 hrs, b. 20 brs ce Shs a 2Shrs 130; If the total body clearance in a patient is 2100 cc/hr, and hepatic clearance is about 300 cefhr, what is the status of renal function? a. Excellent b. . Normal c. Moderately impaired Severely impaired 131. How many milligrams of sodium chlo- tide are required to prepare 250 cc of 1% bo- ric acid solution to isotonic with eye tears? FP of 1% boric acid = -0.29°C FP of 1% sodium chloride = - 0.58°C FP of blood = -0.52°C 250mg 325mg 991 mg 1221 mg apse 132. How many grams of sodium chloride are required to prepare 100 cc of water iso- tonic with blood? FP of 1% sodium chloride =-0.58°C 21Reference guide for Pharmaceutical calculations Second Edition a 045gm bv. 2.3gm c 14gm 4 09am 133, How many grams of sodium chloride are required to prepare a 1 in 100 solution of cocaine isotonic with blood? FP of 1% sodium chloride =-0.58°C FP of 1% cocaine = - 0.09C a 0.74 gm db. 035m e 150gm a 3.57gm 134, How many grams of boric acid are re- quired to prepare a 300 ce 1% procaine hy- drochloride solution isotonic with tears ?° FP of 1% boric acid = -0.29° C FP of 1% procaine = - 0.122°C a 110gm b& 4.1lgm c 2.21 gm 4 151gm 135. Whatis the maximum buffer capacity of bicarbonate buffer with a total concentra- tion of 0.075 mole/liter? a 0.015 b. 0.210 c. 0.043 da 0.145 136. What is the pH of a solution contain- ing 0.01 moles of acetic acid and 0.1 mole of sodium acetate per liter of solution? [Pka = 4.15] a 3.15 be 41S ‘woerphamacyexam.com Krisman, e 245 a 5.15 137. What is the molar ratio of salt/acid re- quired to prepare a buffer having pi =5 and pKa =4.00? a 10:1 b. 50:1 ce 10:1 pen ee sa 138. What s the pH of the solution contain- ing 0.5 molés of ephedrine and 0.05 moles of ephedrine HCI per liter of solution? [ PKb = 4.56] a 5.65 b 7.56 c 8.90 d 10.44 139, The ratio of ionized to unionized ace- tic acid in a solution is 100:1. What is the pH of a solution having pKa 5.5? paar) bea e 45 a 75 140. What is the % of hydrocortisone in.a mixture of 15 gm of 0.1%, 60 gram of 0.25% and 80 gram of 0.5% whw hydrocortisone?. | a 0.36% ww b. 0.50% wiw . c. 1.25% whw a a.Reference guide for Pharmaceutical calculations Second Edition c. 1:500 d 12500 142. What is the pH of a solution having a hydrogen ion concentration of 10° moles/lit? pegse AVE 5 143. An adult LV. dose of Neupogen is 20 meg/kg/week. How many milligrams will a 150 Tb patient receive weekly? a 2.210mg b. 3.120mg cs. 1.363 mg d4.152mg 144, How many ce of 0.75% sodium hy- pochlorite stock solution are required to pre- pare 1 quart of 1 in 500 solution? a :128ee b. Bi2ec ce — 256ce ad Alec 145. If | gm of Cefazolin is reconstituted with 12.5 cc of SWEI, and the resultant solu- tion is inserted into 50 ce of 0.9% sodium chlo- tide, what would be the final concentration of, drug in mg/ml? a. 12mg/ec b. 10 mgiee 16 mgfee a 20mglee 146. 1f2.ce of (5000 units/10ee) Heparin are inserted into 100ce of DSW solution, how many units of drug are present in each ml of solution? www pharmacyexam.com Kristiaii a 10 unitsice bv. 1Sumits/ee ce. 4Sunits/ee d 98 units/ee 147, Ifan.V. admixture contains 1000 mg/ 250 cc of drug and should be infused within a 5 hour period, what would be the flow rate in drops/min? [LV. set delivers 20 drops/cc] a. 10 drops/min b. 17 drops/inin a 35 drops/min_ 4.21 drops/min 148. If 250 mg/500 ce theophylline solu- tion are given in a patient over a 6 hour pe- riod. By 100cc infusion every hour, what ‘would be the strength of theophylline in meg/ ml? a 250mgice bd. 750megice c. > $00mog/oc 4. 340meg/ce 149. 250 mg/500 cc Rocephine solution should be administered to a patient weighing 155 Ibs. The recommended adult dose of drug is 1.5 meg/kg/min. What would be ate of flow in ml/min? a 1.23 ml/min b. 4.21 ml/min ec 0.211 ml/min a& (0,590 m/min 150. If 20 ce of 10% KC! injection are added to 250cc of normal saline solution, what would be the concentration of KCI in meq/ ce? [mw of KCl = 74.5 gnv/mole] a L2meglee b. 0.650 meg/ce ce. 0.423 meq/ee a 0.099 meq/ce 23Reference guide for Pharmaceutical calculations Second Edition 151. Howmany milliequivalents of sodium are present in 480 cc of 20% sodium bicarbonate solution? [muy sodium bicarbonate =84 gm/mole] a 960.65 meq b 425.35 meq c. 686,66 meq 4 1142.85 meq 152, 120 ce of KCI solution (4 meqfec) are diluted with water up to the 250.ce mark, what would be the concentration of drug in mg/ec’? (mw of KCl = 74.5 gm/mole] a 12.23 mg/ec b. 42.25 mg/co c. 23.84 mgfoo a 63.15 mglee 153. Ifaprescription calls to dispense 120ce of KCI in such a way that 1 teaspoonful of solution contains 10 meq of drug, how many grams of KCl are required to prepare the above prescription?[mw of KC1=74.5 am/mole} a 12.25 gm b. 21.15 gm » ce 13.20gm d. 17.88 gm 154, How many cc of Povidone are required to prepare 5 Ib of 10% povidone iodine oint- ment? [density of povidone = 2gm/ec} a 3.20 b. 15.6 ce ce — 10.1ce do 22,7 ce 15S. 1°5000mg oftriamcinolone powder are mixed with 1 Ibof 1 triamcinolone cream, what isthe % of triamcinolone inthe final mixture ? ww.pharmacyexam.com Krisman a 125% ww b. 3.56% wiw ce. (2.19 whw da 42% ww 156. How many cc of Hydrochloric acid are required to prepare 1 gallon of 2.5% hydro- chloric acid? [the purity of HCI acid = 35% w/w, the spe- cific pravity of HCI = 1.25 gm/ml] a 102.11 ee b. 303.15cc ce 219.42cc a 151.15 ce 157. What is the % of elementary iron in 325 mg of anhydrous ferrous sulfate? [iron = 65 mg] a 10% 7 b. 35% ce. 45% da 20% 158. In what proportion should water be mixed with 7.5% acetic acid solution to pre- pare 1 gallon of 0.5% acetic acid? a. 1220¢c b. 2568.ce c.. 1091ec d. 3584cc 159. Ifthe prescription for Cipro reads 500 mg by mouth three times a day, how many days will a bottle of Cipro (10%,100 cc) last? 2.34 days 3.21 days 4.25 days 6.66 days ao geP 24Reference guide for Pharmaceutical calculations Second Edition 160. How many cc of 2% erythromycin topi- cal solution are requised to prepare 480cc of 0.25% topical solution? a 6Dec bd. — 120ce c 30ce da 45ce 161, In what proportion should 3% acetic acid be mixed with water to prepare a 0.5% 1000 ce acetic acid solution? a 166.66 cc b. 108.51 ce c 323.15 ce ad 421.16 ce 162. 178 tablets of 150 mg of amitriptyline are added in 240 ce cherry syrup, how much drug will present in 5 cc of solution? a 50mg b. 25mg c. 15mg 4 125mg 163. How much hydrocortisone powder is required to prepare 240 gm of 1% hydrocorti- sone ? a 12gm b. 3.6 gm. c 24gm a 48gm 164. 3 gms of sodium thiosulfate powder are mixed with 120 gm of aquaphore. What is the % of sodium thiosulfate in a final mix- ture? a Swi b. -2.5% wiw c 125% ww a 10%wiw www-pharmacyexam.com Krismaii 165. If 60 grams of 1% triamcinolone aré mixed with 60 grams of aquaphore ointment , what isthe % of triamcinolone in the final mix- ture? a 0.5% why b. 15% whe c — 3.0% whw da 4.5% wiw 166. 1 cc of atropine (0.4 mg/ec) is mixed with 49 cc of ocean nasal mist, what is the concentration of atropine in mg/ml? Smoglee 0.1 meg/ee 10.5meg/ce 20.1 megiee ae oe 167. To prepare 60 gm of 2.5% xylocaine ointment, how many cc of xylocaine 10% are required? a 10ce. b See ce 25ec d See 168. The prescription for magic mouth reads as follows: aa 60ce Hydramine elixir. Alamag oral susp. Nystatin oral susp. ‘Lidocaine viscous Total. sssencee How many ce of lidocaine viscous solution are required to compound the above prescrip- a 120ce b.— 180ce ce — 60ce ad 90ec 25Reference guide for Pharmaceutical calculations‘ Second Edition 169. If 13 capsuled of Dicloxaeiltin, gach weighing 500 mg, are added to 500 cc of Alamag suspension, how many milligrams of drug are present in 5 cc of the final solution? a 13mg b. 26mg c 65mg ad 52mg 170. 8 cc of 10% Povidone-lodine solution are diluted up to the 1000 ce mark with p fied water. What would be the concentration of Povidone-Iodine in mg/ec? a 1.2mg/ec : b,-24mg/ec c. 3.2 mgfoe 4. 08 mg/ee 171. 2capsules of chloramphenicol 500mg are added to 30 grams of fluocinonide cream. ‘What is the % of chloramphenicol in wiv? a 2.52% b. 4.12% 5.63% ad 3.33% 172, 8 capsules of clindamycin each weigh- ing 150 mg are added to 60 cc cetaphil cleanser, What would be the concentration of drug in mg/ec? a 12 mg/ec. b. Omgiee 35 mglee a 20mglee 173. To prepare 60 gm of 2% Clindamycin topical gel, how many capsules of Clindamy- cin each weighing 150 mg are required? a 2caps bd. Bcaps ‘www pharmacyexam.com Krisman ce caps a Acaps 174, To prepare 1000ce of 0.25% of Dakin solution, how many cc of 5% sodium hy- pochlorite are required? a 100 cc b.50ce co 60cc ad ' 40ce 175. To prepare 1 mg/5 ce (120 cc) solu- tion of Trilafon, how many ce of Trilafon (img/ce) are required? a Wee one 35.60 e. Weo a 0c 176. 2c of Vancomycin injection (250 mg/ cc) are added to 8 ce of isoptotears. What is the final concentration of drug in mg/cc? a. 75 mglee b. 25 mgfec ce. 50mg/ee a 80mglee 177. Anadministration of 1.5 gm/kg/day of amino acid via peripheral infusion normally achieves optimal fat metabolism and spares protein catabolism. What would be the dose of amino acid in grams for 155 Ib patient? a 23.45 gm b 190.60 gm_ c 89.65gm ad 105.68 gm 178. Howlong willit take to administer 2500 ccof TPN solution with arate of 60ml/ke/day in patient weighing 140 Ibs?Reference guide for Pharmacentical calculations Second Edition a 15.71 hours b. 22.24 hours c. 10.86 hours d. 9.75 hours 179. How many éalosies are provided by 500 ce of D,,W solution? a, ‘145 calories b. 510 calories ce. 325 calories 4252 calories 180. How many total calories are provided by 1000 ce of 5% dextrose and 5% alcohol? a. 131 calories b. 450 calories c, 253 calories 4. 75 calories 181. The maximum recommended rate of infusion of dextrose solution is 0.1gm/kg/br. How many hours will it take to infuse 1000 co of D,,W solution in a patient weighing 155 bs ? a. 10.15 hours b. 30.12 hours c. 42,58 hours 4.7.15 hours 182. 2.4 liters of 5% alcohol solution are administered to a patient with a rate of 0.33ce! min, How many hours will it take to finish the whole infusion? a 121.21 hours b. 90.15 hours c 45,65 hours 4. 75.67 hours 183. Refersing tothe ahove question, ethanol ismetabolized at arate of 20 cc/hr. Will it make. the above patient sedate? ‘www pharmacyexam,com ‘Krisman “Yes No Cannot say 4 Cannot be caloulated ere 184, What is the volume of dextrose solu- tion required to prepare a peripheral parenteral nutrition for Mr.Shroff that provides 1100 nonprotein calories and 30 gm of amino ac~ ids? The formulation should provide 45% of nonprotein caloties as fat and have a maxi- mum dextrose concentration of 12.5%. a $76.15 ce b. — 823.18cc ce. — 1423.52ce gd. 390.63 ce 185. How many cc of amino acid solution are required to prepare a 3% amino acid solu- tion containing 30 grams of amino acids? a 500ce b. — 1000ee c — 250ce dd 355¢ce 186. Using the Harris Benedict's equation, whats the Basal Energy Expenditure for Mrs. Shahel? es ‘Age = 35 years, W = 1201bs, H = 5*2” BEE,,..,= 655.10+9.56xW+ 1.85xH ~4.86xA = weightinkg heightinem ageinyears a 1100.11 calories b. 986.5 calories c. 1304.03 calories d. 825.05 calories 21Reference guide for Pharmaceutical calculations ‘Second Edition 187. What would be the total calories provided by a TPN mixture containing 1200 ce of DSW, 1000 ce of 10% amino acids, 100 ce of 5% alcohol and 300 cc of 20% fat emulsion ? a 575 calories b.. 250 calories ©. 680 calories d. 1172 calories 188. Ifa prescription for TPN calls for pro- viding 55% of 1500 nonprotein calories as a dextrose, how many ce of D,,W are required? a 451.52.ce b. -323.32c¢ ce. 808.82 cc 616.15 ce 189, If a prescription reads to compound TPN that provides 45% of the 2000 nonpro- tein calories as fat and the remaining 55% as, dextrose, how many ce of 20% fat solution are required? a 1000ce b.-250ce c — 750ce d 500ce 190. How many ce of 5% amino acid solu- tion are required to provide 2gm/kg/day ina patient weighing 165Ibs? a 1500ce b. 500ee c 3000 ce 4 2000ce 191. How many calories are provided by 250 coofS% glycerol? a. 101.S2calories b. —-75.82calories www pharmacyexam.com ‘Krisman c. 53.75 calories d 41.11 calories 192. How much calories are provided by 500 cc of 20% lipid solution? a 500 calories b. 750 calories ce. 475 calories d. 900 calories 193, A prescription reads “Alphagan 0.2% drop, 1 drop od gid x 10 days”. How many milligrams of Alphagan are present in each drop of solution? (1 drop =0.1cc) a 12mg b-24mg c 02mg 4. 0,002 mg 194, How much Timolol is present in 10 cc of 0.5% Timolol opthalamic solution? a 500mg b 05mg c 5gm a4 50mg 195, Ifa prescription for Haldol decanoate Teads “75 mg im. twice a week x 4 months”, how many vials of haldol decanoate (100 mg/ co, 1 ec) are required to fill the above order ? a 2Avials b. 12 vials c. 10vials 50 vials ot son gates 28 | | |Reference guide for Pharmaceutical calculations Second Edition ce. 80calories d. 90 calories 197. In what proportion should 2% acetic acid be mixed with 10% acetic acid solution to prepare 500 co of 5% acetic acid solution?” a 102.12 ce b. 204.15 ce c. 312.50ce 4. 405.90 ce 198. A tapering dose for prednisone is as follows: “40 mg po qdx | day then taper 10 mg everyday until D/C”. How many tablets of 5 mg are required to fill the above order? 10 tablets, 5 tablets 20 tablets 15 tablets ao oe 199. How many milliequivalents of sodiumbi- carbonate are present in 50 ce of 50% so- dium bicarbonate? [mw = 84 gm/mole] 131.15 meq 204.25 meq 302.10 meq 297.61 meq pe re 200. Whatis the half-life of a drug in a day, if the degraded constant of the drug is 9.9 x 10° days? [first order kinetic} a 3Sdays b. 60 days: © 70 days d 105 days 201. How many grams of Ainoxicillin are present in 200 cc (250mg/5 cc) of Amoxicillin sotution? www.pharmacyexem.com ‘Krisman a Sgm b. 1Sgm c. 10 gm. a 20gm 202. A prescription calls for Demerol, “75 mg IVP q6h pr pain x 7days”. How many vials of Demerol (100 mg/cc) are required to fill the above order 7 a. 10 vials b. — Lyials c. 15 vials d > 21 vials 203. Which of the following are correct DEA numbers for Dr. Sheghi, Rama? a. . BS4312567 b. AR3252181 c. —_ BR4530895 d. 482332764 204, How long will ittake toinfuse 250 cc of D,,W solution ina patient with a flow rate of 0.5 celsecond? a. 2.50 minutes b. .60 minutes c. 8.33 minutes 4. 10.12 minutes 205. If an adult recommended dose of a drug is 5 mg/kg/day, how many milligrams of the drag will a patient receive every 4 hours? [patient weight = 110 Ibs} 55.12 mg 101.23 mg, 41.66 mg 24.84 mg pose 29Reference guide for Pharmaceutical calculations Second Edition 206. How many calories are provided by 500 cc DW, 300 cc 3% amino acid and 500 ce of 10% lipid solution? 123 calories 205 calories 401 calories 571 calories ae gp 207. How many milliequivalents of Kr are present in 400 cc of 20% solution of KCI? (mw of KCl = 74.5 gm/mole) a 576,80 meq b. 432.11 meq c. — 808.16meq 4 1073.82 meq 208, What is the ratio of ionized to union- ized drugs at pH = 6? [PKa= 4] eoge 209. A drug with a weak base property has aPKb value of 85. Whatis the ratio of unionized toionized drugs at PH=6.5? a. 100:1 bho cy lO a&. 1:100 210. A Viracept powder (144 gm) prescrip- tion is written as follows: “1250 mg by mouth twice a day”, How many scoops (each 50 mg) are required per day? 100 scoops : 5 scoops 50 scoops 25 scoops ee oP wvvepharmacyexam.com Krisman 211. Referring tothe above question, how long vwillit take to finish the whole bottle of drugs? a 23.1 days b. 14.5 days c. 33.5 days 4 57.6days 212. fan .V. order is prescribed to admin- ister 0.2 mg/kg/day of theophylline, how many, milligrams will patient receive per day? {patient weight = 120 Tbs} a7 123mg bd. 856mg c 421mg ad 109mg 213. How many capsules each of 750 mg KCl are required to prepare a 10% 180 cc so- lution of the drug ? (aw of KCI= 74.5 gm/mole) a 10 b 15 Gaal a 24 2114,. How long will it take to decompose the drug to 50 mg/ce? The initial concentra- tion ofthe drug was 500 me/ee with a half life of 9.9 x 10 minutes. a 0.15 minutes b. 1.29 minutes c. 0.329 minutes 4. 0.809:minutes i { iReference guide for Pharmaceutical calculations Second Edition a 10mg b 15mg ce 25mg a 55mg 216. Ifthe sensitivity of the balance is 4 mg, ‘what's the minimum permissible quantity hat can ‘be weighed on a balance? [an error of +5 is per- missile] a 80mg b. 100mg ce 150mg d& 250mg 217. If the sensitivity of balance is 3 mg, what is the minimum permissible quantity that can be weighed on a balance when an error of + 1is acceptable? a, 300mg bd. 250mg ce. 75mg a. 50mg 218. ifabalance hasa sensitivity of 3mg, what isthe % error allowed? [minimum weighable quantity is 150 mg] a 41% db. -£2% c £5% a #10 219. In essay of ethyl nitrite spirit, nitric oxide gas is liberated from a spirit and col- lected ina gas burette that occupies a volume of 50.ce at a temperature of 25°C and a pressure of 710mm Hg. What is the volume of gas at °C and 760 mm Hg? [assume that gas behaves ideally] a 101.23 ce b. 42.79 ec www-pharmacyexam.com Krisinan ce 2.15ec ad 80.85 ce 220. Calculate the value of the molar gas con- stantR at STP. The volume of gas found is 22.4 Titers at 1 mole of an ideal gas. a. - 0,064 atm lit mole K° b. 0.152 atm lit/ mole Ke c. 0,082 atm lit/ mole K° 4. 0.76 atm|lit/ mole K* 221. What is the volume of 3 moles of an ideal gas at 20° C and 740 mm He? IR = 0.08205 lit atm/ mole deg] 25.151, 35.10L 74.07L 52.10L, Be oP 222. If 0.5 gm of methylacetate in the va- por state occupies 500 ce af'a pressure of 780 mm Hg and temperature of 120° C, what is the molecular weight of methylacetate? a.» 20.15 gm/mole b. 31.41 gm/mole c. 1050 gm/mole 4 5.60.gm/mole 223. 1f50 gms of ferrous sulfate are diluted with water up to 1000 cc, what would be the molarity of the solution? [mw of FeSO, = 151.90 gm/mole] a 05M b. 12M c. 0331M ad 21M 224, Whatis the % mole fraction of ferrous sulfate in a solution containing 25 grams of ferrous sulfate in 1000 gm of water? [mw of FeSO, = 151.9 gm/mole, mw of HO =18gm/mole} 31Reference guide for Pharmaceutical calculations Second Edition a 752% db. 23.11% c 0.29% a | 99.71% 225. 1f0.2M solution of acetic acid dissoci- ates in 1.2.x 10* moles each of hydrogen and acetate ions at 25°C, what is the dissociation constant Ka for acetic acid? a 12x10¢ b. 24x 108 ce 72x10" d 35x 10% 226. The ionization constant Kb for a mor- phine base is 3 x 10% at 25°C. What is the hy- droxylion concentration of a3 x 10*M aque- ous solution of morphine? a. 9x10" moles/lit b. 3x 10% moles/lit c. 1x10? moles/lit d_ , 9x10*molesit 227. Aduantity of hydrochloric acid (0.1 M) ‘isadded to increase the H' ion concentration from. 1x 10" to 1 x 107 moles/liter. What is the new ‘hydroxyl concentration? a. 1x10*molestliter b. 1x10" molesfliter ce. 1x10 moles/lter @ 1x10” molesfiter 228. Ammonia has a Kb of 1.5 x 10% at 25° C. What is the Ka for its conjugated acid NH4* at the same temperature? a 12x10¢ b.085x10" ce 066x108 a. 034x104 worw.pharmacyexam.com, Krisman 229, Themeasured solubility ofsilver chloride ‘in water at 25° Cis 1 x 10+ moles/liter. Whatis the solubility product ofthis salt? a 1x 10" been 108 G, 1x 107 dixie 230. What is the solubility of silver chro- ‘mate in moles/lter in an aqueous solution con- taining 0.08 M of silver nitrate? The solubil- ity of silver chromate (Ag,CrO,) in water is 8 x 10% [KSP=2x 10] 105.56 x 10 moles / liter, 85.23 x 10* moles / liter 43.56 x 10 moles / liter 312.5 x 10" moles / liter ao oP 231. When boric acid is distributed between water and methylalcohol, the concentration in water and methylalcohol were found to be 0.06 molesfiiter and 0,03 moles/liter. What is the distribution coefficient? a lors b. 20r05 c. 40r2 d 150r3 232. 10 gmof aspirin powder is dissolved im 100 cc of solution. The solubility of aspirin, at 25°Cis 0.33 gm/100 ce. The first order rate constant for aspirin degradation is 5 x 10$sec- ‘ond. What is the zero order rate constant? a. b $ c 1.30 x 10%. a@ 142x104: i 233. Theinitial concentration ofadrag decom- posing according to first order kineiis 10? units! ml. When the concenitration of drug falls below 32Reference guide for Pharmaceutical calculations Second Edition 10° units/ce, it should be removed from the ‘market. What would be the expiration date for this product? (K = 2.303 x 10" hour! } a. 20x 10° hours b. 40x10? hours ce. $x 10? hours a 40hours 234, A sample of methylspirit rose to a eight of S cm at25°C in a capillary tube hay- ing an inside radius of 0.05 cm. What is the surface tension of methylspirit at 25°C ? Den- sity of methyl spisit is 1.5 m/em. 121.56 201.11 183.93 305.12 ap oP 235. If a droplet of oleic acid is placed on water having a surface tension of 72.8 dynés! em at 20° C and an interfacial tension of 30 dynes/om. Will the oleic acid spread on wa- ter? Surface tension of oleic acid at 20°C:= 35 dynes/cm. a 105 b. 201 cc 355 da 128 236, An O/W emulsion containing turpen- tine oil with a specific gravity of 0.45 is dis- persedin aqueous phase having specific gravity of 1.05. Ifthe ol particles have an average diam- eter of 10 micrometers and the viscosity of external phase is 0.25 dynes/om®, What is the velocity of creaming in cm/day? [g= 981 om/sec*] a 24x10" b.-13 x 108 wwwpharmacyexam.com Krisman c 23x10 ad 31x10" 237. How many milliosmols per 100 ce ate present in 500 ce D,.W solution ? [mw of dextrose = 180 gm/mole] a 138.88 be 1388.88 e. 456.23 ad 520.15 238. What is the osmolarity of 500 cc of 25% sodium bicarbonate solution ? [mw = 84 gm/mole} a $952.38 b. 2763.18 c. 7032.11 4. 1809.09 239. How many milliosmols per liter of CaCl, are representated by 50 ce of 20% CaCl, solution? a $405.4 b. 1232.11 c. 2516.15 a 3315.23 240. In what proportion should 3% 200cc boric acid solution be mixed with 8% boric acid solution to prepare a5% 100 ce boric acid solution? a —-:100ce b. 60ce c. 40ce ad 50ce 241, How many milliequivalents of Nat ions are present in a 50% 50 ce solution of sodium bicarbonate? [mw of NaHCO, = 84 gm/mole} 33Reference guide for Pharmaceutical calculations Second Edition a 105.32 b. 325.16 ce. 297.61 a 40119 242. One teaspoonful of chlorpromazine concentrated solution (30 mg/cc) is diluted up to 240 ce with distilled water; 10 cc ofthis resultant solution are diluted up to 1000 ce with distilled water, What would be the concentration of drug jinmegfoe inthe final solution? a 625 esse 62's) e625 d 0.00625 243. Calculate the osmolarity of 200 cc of 0.9% sodium chloride solution. a 805.11 b 307.69 e. 420.11 a 105.21 244, How many milliosmols/L are represen- tated by 30 ce of 10% KCl solistion? a 1232.11 Db. 980.05 c. 2684.56 a 1411.23 245. An LV. order for250mg/100 ce should be administered via LV. infusion overa 12 hour period. Ifthe LV. set delivers 20 drops/cc, what Would be the flow rate in drops/min’? a 128 b. 15.60 c 8.90 427 www.pharmacyexam.com Krisman 246. 20ccof 10%KCI sotution, 50.ccof 25% ‘NaHCO3 solution and 30 cc of 20% CaC2 are mixed with 5% 1000 cc dextrose sdlution. The infosion should be administered over Shouts. What isthe flow rate in drops/min ?[L. set delivers = 10 drops/cc] a 13.19 b 14.05 c 18.01 d 22.91 247. How long will it take to infuse 500 cc of DSW solution if the flow rate of the solu- tion is 20 drops/min? [LV. set delivers 20 drops/ec] a 1.Shours b. 10.11 hours c. 5,60 hours ad 8.33 hours 248. Calculate the flow rate in drops/min to infuse 300 cc of clindamycin solution over a4 hour period. [LV. set delivers 15 drops/ec] a 20.12 v8.75 e 75 ad 1630 249. if the normal therapeutic recom- mended dose of metronidazole is 10 mg/ke/ day, how many infusion bags of 250 mg/100 ce are required? [pt weight = 155 Ibs] ° peep wre 250. How much dextrose is required to pre- pare 1 in 100, 50 cc dextrose sofution? 34crpneeenmcanpeenee=e trseoyenr Reference guide for Pharmaceutical calculations Second Edition a 05em b 2gm ce i5gm a4 36gm Ba www.pharmacyexam.com Krismant 35Reference guide for Pharmaceutical calculations Second Edition ANSWERS www>pharmacyexam.com 36Reference guide for Pharmacentical calculations Second Edition 1. (b) 2.4 grams. The amount of sulfur required to fill the above prescription is 80x3 = 2.4 grams. 100 2, (b) 500 ce of 5% Dextrose solution con- tains: 500x5 = 25 grams of dextrose. 100 3. (©) 1: 1000 is generally interpreted as 1 ‘gm in 1000 cc of solution, The amount of Tidocaine in’30 cc of 1:1000 solution can be calculated as follows: = 30x 1000 0.03 gm = 30 milligrams. 4, (d) 1 grain is equal to 65 milligrams, there- fore 1/150 grains are equal to: =1x65.5 150 43 milligrams 5. (d) 1 in 100 solution is interpreted as 1 gm of drug in 100 cc of solution, We want to find ‘outhow much atropine is required to dispense 1 quart (960 cc) of 1 in 100 solution, there- fore: = 960.x1 = 9.6 gm atropine = 9600 mg. 100 6. (c) To solve this type of problem, we need to use the alligation method. So (75%) Ce eo (10%) ‘Total parts 65 (30%) www>pharmacyexam.com ‘Krisinaa ‘To prepare 65 (30%) 20 parts (75%) needed To prepare 500 (30%) ? = 500.20 = 153.84 cc (75%) alcohol 65 If we mixed 153.84 cc of 75% alcohol with 346.16 cc [500 ce - 153.84 ce] of 10% aleo- hol, then we can get 500 ce of 30% alcohol solution. 7. (b) We want fo prepare 1 quart (960 cc) of 0.45% heparin solution, therefore we can say = 960x045 = 100 432m. 4.32 gms of heparin are required. 8. (a) This type of calculation is classified as a dosage calculation and can be calculated as follows: ‘We have a suspension of Augmentin 250 mg/ S.cc and we want to dispense dose of 875 mg, =S.x875 = 17.5cc 250 ‘The patient is taking 875 mg twice a day and therefore: =2x 17.5 co =35 cc per day. Patient is taking drug for 10 days therefore, = 35 x 10 = 350 ce would be the dispensed quantity of drug. 9. (b) 250 mg (0.25 gm) of cefazolin pow- der are diluted with water up to 250 ce mark and we want to find out the % of drug in the final solution. 37Reference guide for Pharmaceutical calculations ‘Second Edition = 100x025 = 0.1% 250 10. (c) 1 teaspoonful (5 cc) of Thior- idazine solution (30mg/cc) contains 150 mg of drug. This solution is diluted up to a mark ‘of 480 ce therefore: = 150 = 031 mg/ml 480 IL. (@) ‘We have 12.5mg/Scc Benadryl solution. We want to dispense 4 50 mg dose: = 50x5 = 20ce for I day 125 For 30 day supply: = 20x30 =600ce. 12. (d) Erythromycin 2% topical soli- tion contains = 60x2 100 = 1.2 gmof erythromycin. 13.(€) ‘The % of elementary iron can be found as follows; = 100x60 325 18.46% 14. (b) in 60 gm, 1%: ‘The amount of Hydrocortisone 60 = 0.6 gm of hydrocortisone. 100 Amount of hydrocortisone in 80 gm. 2.5% 80.2.5 = 2 gm hydrocortisone 100 f cortisone in. ixture, wwwpharmacyexam.com Krisman = 100x2, m. 140 (80 gm+ 60 gm) = 1.85% wiw. 15.(c-) — Lampul Pationt is taking 100 meg of the drug LM. ev- exy week, therefore: = 100 = 0.1 cc of drig every week. 1000 of ce requir =0.1x4=04cc The correct answer should be 1 ampul, 16. (d) 1000 tablets of Risperdal Img cost $2250. The % mark up on prescriptions is 20%. ‘Therefore the retail price of 1000 tablets would be: = 1202250 = $2700 100 ** Each $100 cost = $120 retail cost** Price for 30 tablets would be: = 30x2700 = $81 1000 i 17.4) We want to find out the quan- tity of Clobetasole present in 60 grams of 0.5% ointment. = 60x05 = 03 gmof clobetasole. 100 es 7Reference guide for Pharmaceutical calculations Second Edition 18. (c) A pH of the solution can be found by the following formula: pH = pKa + log io unionize = 2.2 + log lO 2.2 +3 52 19. (b) We have 400 mg/5 cc Aug- ‘mentii in stock. We want to find the dispensed quantity for a 10-day supply. = 815x5 = 10.93 ce for each dose 400 ‘The patient i taking a dose twice a day for 10 days therefore : = 10.93x2x10 = 218:75¢c 20. (a) sper Weight in grams = no of ml x = 500ce x 1.25 gm/co = 625 gm 21. (a) Weight = density x volume Volume = weight density = Sx 454 1.25 (Ib =454 gm) 1816 ce glycerine. 22.(b) Weight = density x volume =2.5x500 = 1250 gm of acid. ww w,pharmacyexam.com Krisman, 23.(c) pH = pKa + log salt acid 7 = 5+log salt acid log [saltacid] = 2 salt/acid = 10?, ratio of ionized to unionize drug will be 100. 24.() pH = - log [H,0°] 3 = - Jog [H,0°] log [H,0°] TH,0°} = 10° gmion 25.(d) pH = pKa + log [salt/acid] + log[ 105} 1-6 =i 26. (d) 240 cc 2% Erythromycin so- Jution contains: = 40x 2 = 4.8 gm of Erythromycin 100 ‘The number of 500 mg tablets of Erythromy- = 4800 = 9.6 = 10 tablets. 500 27. (©) 1 grain is equal to 65 mg there- fore: 1/150 grains will contain: = Lx 65 =0.43 mg 150 28. (a) 100 tablets of Lgrain of Aspirin contains: 100% 65 = 6500 mg of Aspirin, 39Reference guide for Pharmaceutical calculations Second Edition ‘Thenumber of 975 mg tablets of Aspirin: = 6500 = 6.66 = 6 tablets 975 29. (b) contains: 1 % 150 ce Cleocin solution = 150x1.= 1.5 gm Clindamycin 100 ‘The addition of 3 capsules each weighing 150 ing will result in: 1.5 gm +045 gm = 1.95 gm % of Clindamycin in final mixture would be: = 195x100 = 13% 150 30. (a) 71.42 mg ‘Young rule = age in year x adult dose age + 12 = 2. x 500 =71.42 mg 4 31. (a) 100mg Clark’s rule = Weight in ibs x adult dose 150 = 20 x 750 = 100mg 150 32.(0) 0.06 ee According to Fried’s rule: = agein months x adult dose 150 15x 225 = 325 mg 150 www.pharmacyexam.com Krisman ‘The dropper is calibrated to deliver 325 mg of Iron sulfate in 0.6 cc, therefore: = 0.6325 = 0.06ce 325 33. (d) 11.56 mg A child dose can be calculated by: = Body surface area of child x adult dose 173 mot = 2x10 173 = 156mg 34.(d) 1 grain is equal to 65 mg, there- fore 10 grains contain = 10x65 = 650 mg of the drug. 35.(c) _ Patient weight is 1561bs, there- fore weight in Kg would be 156 ='70.9 kg. 22 A normal therapeutically,recommended dose of drug is 10mg/kg/day, therefore the dose in the above patient is: = ie 10x 70.9 109 mgReference guide for Pharmaceutical calculations Second Edition = 1x65.x1000 100 = 650 micrograms [1 mg = 1000 meg] A prescription calls for 50 meg of adrug three times a day for 10 days, therefore the number of tablets required to fill the order is: = 50x3x10 = 2.30 = 3 tablets 650 37.(a) A patients taking 125 meg of Lanoxin every day, therefore to fill a 30 day order, = 30x 125 = 3750 meg of Lanoxin. Each ml of Lanoxin elixir provides 50 meg of admug, therefore the number of cc required to fill the entire order is: = 3750 = 75 cc of Lanoxin el 50 38. (a) A prescription reads to dis- solve 2 gm of Guaifenesin in 100 ce of plain water, therefore the amount of drug present in. 1 teaspoonful (5 cc) of solution would be 39. (b) 100mg of Lactaid is equal to 4500 units, there- fore 1 unit is equal to: = 100 = 0.02 mg of Lactaid 4500 40. (c) 2B ce AT year-old child is taking 50 mg Ampicillin by mouth twice a day for 7 days, therefore: www pharmacyexam.com Krisman = 50x2x7 = 700mg of Ampicillin ‘We have 125 mg/5 ce suspension in stock: = 5x00 = 28ce : 125 41.) 477mg An adult dose of drug can be calculated by the following formula: Body surface area x adult dose 173 mm* = 110 x 750 = 476.87 mg-= 477 mg 173 42. (@) contain: 240ce of 10% solution will = 240x110 = 24 gm of drug. 100 43. (c) 6.75 gm sodium chloride ‘The amount of sodium chloride required: = [50x09 = 6.75 gmof sodium chloride 100 44. (b) D,,W. will be interpreted as 25% Dextrose solution. ‘The amount of dextrose present; 00x25 = 125 gm of dextrose. 100 45. (a) 1: 1000 solution isinterpreted as 1 gm of dmg in 1000 cc of solution. 41Reference guide for Pharmaceutical calculations Second Edition = 30x1 =0.03 gm =30 mg of Lidocaine 1000 46. (a) 1.33 gm of Povidone-Iodine. Thea Pe Todi = 1000 = 1.33 gm of povidone iodine 750 47. (b) 20 gm of dextrose tof dextrose requir = 5000x1 = 20 pm of dextrose 250 48.(c) 1 in 20 solution is interpreted as 1 gm of drug in 20 ce solution, =100x1 = 5% boric acid 20 49. (d) An amount of thioridazine re- quired: = 2505 = 125 gmof drug = 12,500 mg "100 tock soluti wii = 12,500 = 416.66 ce = 417 cc 30 50. (d) 20 ce of 1 mg/cc Risperdal so- ution contains 20 mg of drug. Sire in the ut = 20°= 0.08 mg /ee 240 ‘www:pharmacyexam.com Krisman 51.(¢) To solve this problem we can use the ratio-proportion method. V,C, = V,C, V1 = 150x0.2 = 214.3 cc of 70% alcohol 07 52.(b) 1 500solutionis interpreted as 1 gm of drug in 500 ce solution, therefore: = 3x960x 500 5.76 gm of Atropine. 53. (a) 50 grams. = 500x10 = 50 grams of Povidone Iodine 100 54.(a) To solve this problem, we can use the alligation method. 5, 2(S%) ee [ 3 os 2(1%) Total parts 4%) To prepare 4 parts (3%) 2 parts (5%) ‘To prepare 500 gm ? 3 = 5002. = 250 gm of 5% salicylic acid. 4 55. (b) To solve this problemi, we imust first find out the amount of drug present in ‘the final solution. ‘The amount of airopine in 1 pint, Lin 500 sol" 2 3h Ogg ; = 480 x1 '= 0.96 gal of atropine, 500ce guide for Pharmaceutical calculations Second Edition Now, 0.96 gm of drug must be present in 1 teaspoonful of the drug solution, therefore we can say: See (I teaspoonful) contains 0.96 gm 240ce solution requires? = 240.x.0.96 = 46.08 gm of atropine, 5 56. (c) The amount of compazine present in 2 quarts of 0.1% solution = 24960401 = 1.92 gmof drug. 100 ‘Number of ampuls required: = 1920mg = 384 ampuls 5 mg 57.(d) 800 gms ointment. = 100.x2 = 800 gm ointment 0.25 58. (d) ‘The gram equivalent weights of solute in I liter of solution is defined as normality, therefore 1N solution of sodium bi- carbonate will contain 84 gms in 1000 cc. ‘We want to find the quantity of sodium bicarbonate in 240 cc, 0.1 N solution. LN solution contains 84m 0.1 Nsolution contains? =0.1 x84 = 8.4 gms/1000 ce. 240 ce = 240x 8.4 = 2.016 gm of NaHCO, 1000 59. (0) IN solution of HCI will con- tain 36.5 gms per 1000cc, therefore 0.05N solution will contain: ‘veww.pharmacyexam.com Krisman = 0.05. 36.5 = 1.825 gm HCV1000cc 1 '500cc solution will contain = 0.912 gm HCI ‘Wenced 0.912 gm C1 acid and purity of con- centrated HCl is 37% wi, For 37 gm pure HCL 100 gm HCl For0.912gmpureHCl 2 = 1000912 = 2.46 gmHCl 37 Volume of cone. HCl = 2.46 12 2.05 ce HCI 60 (b) 1.42% whw 2% 60 gm HC contains % 80 gm HC contains 140 gm HC contain 1.2 gmHC 0.8 gmHC 2.0 gmHC % of HC in final mixture: = 100x2 = 1.42% wiw 140 61. (a) 36.08% w/v alcohol quart 30% aleohol contains: = 960x30 = 288 cc alcohol 100 = 1440x40 = 576 cc 100 ‘Total amount of alcohol is (576 + 288) in (960 + 1440) therefore % of alcohol in final mix- ture is: = 100x866 = 36.08% alcohol 2400 43jReference guide for Pharmaceutical calculations ‘Second Edition 62.(a) _Tosolvethis problem, weneed tovuse the alligation method. tl 1.50 (3%) So 25 1s Ns stga Total parts 2.00 (2.5%) For 2 parts 2.5 % requires 1.5 parts For 200 ce 2.5% requires 2 = 200x115 2. = 150 ce of 3% acetic acid should be mixed with (200 co-150 cc) 50 ce of 1% acetic acid to prepare 200 cc of 2.5% acetic acid, 63.(b) To solve this problem, we can use the alligation method, or 15 (60%) ow 58, 40 ss Total parts 20 (55%) For 20 (55%) parts 15 parts (60%) require For 400(55%) 2? = 400x 15. 20 = 300 gm 60% w/w HCI acid is required. 64. (c) 333cc water is required, Se 25 (45%) 25 sh eo 20.(0%) Total parts 45 (25%) www>pharmacyexam.com Krisman For 45 (25%) parts 20 parts of water req For 750 (25%) alcohol. 1 = 150.x 20 45 = 333 ce water. 65. (d) 175 ce of 25% dextrose solu- tion. “Cp 5 (25%) 10, ‘Total parts 20 (10%) For 20(10%) parts 5 parts (25%) require For 700 cc 10% 7 = 0x5 20 = 115 ce of 25% dextrose solution, 66. (d) A quantity of solution that con- tains 1/2 gallon of pure alcohol (absolute) is said to be 1 proof gallon: Alcohol USPiis 95% vi. Taxable alcohol means numbeis of proof gallons. eso 1 gallon = 4 quarts Proof gallon = gallon x % strength ¥ 44 ponies 4 we elueieessReference guide for Pharmaceutical calculations Second Edition = U8 x50 50 = 0.125 gallons. 68. (c) Proof gal = gal x % v/v strength 50% viv fluted al JSP is 49% gal = proof gal x 50% % strength = 05 x 5 49 0.510 gallons. 69. (b) 0.05 proof gal Proof gallons = gal_x_% v/v 50% . = 28x10 = 0.05 proof gallon 50 70. (a) 0.263 gallons Proof gal = gal x_% v/v strength 50% Gal = 50_x proof gal, % VIN = 50 x05 = 0.263 gallons 95 Tl. (a) ‘To prepare saturated solution, 1 gm of boric acid should be dissolved in 12 cc of solution. 240x1= 20 grams of boric acid. 2 www pharmacyexam.com Krisman 72. (b) 200 units/ec ‘The amount of Abbokinase units in 5 cc of reconstituted solution: },000 units/ec 2.ce of this resultant solution are injected into 500 cc of 5% dextrose solution: 100,000 500 = 200 units/ec. 73. (©) 360 ce, ‘The ce of Valproic acid will need to fill 600 mg dose, = 5x600 = 12ce 250 ‘A patient is taking 600 mg three times a day for 10 days, therefore: 74. (d) 20% elementary iron 525 mg of Ferrous sulfate contains 105 mg elementary iron. = 100x105 = 20% 525 75. (d) 21 ce. = 5x105 = 2lec of Tbert-500 liquid. 25 76. (c) The weight of a child in kg 50 = 22.72kg. 22 45Reference guide for Pharmaceutical calculations Second Edition ‘The recommended therapeutic dose in a child is 4 mg/im/kg, therefore: 2.72x4 = 90.9 mg Number of ampuls =90.9 = 0.9 = 1 100 77. (b) 2mg. A nilligram of albuterol sulfate is required to prepare 2.5 cc 0.083% solution, = 2.5x0.083 = 0.002 gm = 2mg 100 78. (a) A patient is taking 2 drops in each eye four times a day, therefore the total number of ml would be 1.6 cc (Ldrop =0.1c¢). ‘Thenumber of mg of Alomide present in daily dose: = 16x01 = 0.0016 gm = L6mg 100 79.(a) 75mg U. in 5 ce. = $x 50,000 =250,0001.U. Each LU. contains 0.3 meg of vitamin-A: = 250,000 x 0.3 meg = 75000 meg =75 mg 80, (b) The amount of Lidocaine present in 30 cc of 2% Lidocaine viscous so- ution is: = 30x2 = 06em 100 = 600 mg. ‘weww>pharmacyexam.com Krisman 81. () ‘The number of ec of Megace oral solution re- quire: = 800 = 20 cc 40 82. (d) 2. gram (2000 mg) of Videx powder are reconstituted with 200 ce of puri- fied water: = 2000 = 10mg /ce 200 10.ccof this resultant solution (10x 10 = 100mg videx) is mixed with 200 cc of Maalox plus: = 100 = 0.5 mgiee. 200 83. (€) —Thenumber of ce of Cefail oral suspension are required to fill one dose are: = S00x5 = 20cc 125 20ce x4.x7 560 cc. 84. (a) The amountofelemeiitary iron present in 325 mg of ferrous ‘sulfate: = 325x20 = 65 rig of elementary iron’ 100 7 ‘The number of ce of Niferex liquid required: od blsoald Blew oirod™ = 5x65 = 3.25.6 of Niferex solution.Reference guide for Pharmaceutical calculations Second Edition 85. (a) ‘Tosolve this problem, we should use the alligation method, x 3 (20%) ao 2.(5%) ‘Total parts 15 (8%) ‘To prepare 15 parts 12 parts To prepare 500 ce a = 50x12 15 = 400 ce of 5% Hydrochloric acid should be mixed with (500 cc-400 ce = 100 cc) 100 ce of 20% Hydrochloric acid to prepare 500 cc ‘of 8% Hydrochloric acid. 86. (b) 1 gm of Rocephin in 250 cc 0.9% NaCl should administer within 24 hours, therefore = 250cc 24x60 min = 0.173 ccfmin. An LY set delivers 20 drops per ce, therefore: For lec 20 drops require For 0.173 cc ? 0.173 x 20 3.47 drops per minute. 87. (c) An adult dose of drug can be calculated by the following formula: = Patient's surface area in mm? x adult dose 173 mm? wwwpharmacyexam.com = 123 x 5000 173 = 3554.9 units of heparin. 88. (d) The milligrams of lidocaine presents in 5 cc of 1% lidocaine solution are: = 5 = 0.05 gm = 50mg 100 89. d) The total amounts of Insulin used by patient per day: = 10+20 = 30units. ‘The number of days the insulin (100 units/10 cc) vial will last: = 100 = 3.33 days, 30 90. (©) ‘The amount of Acetic acid re- quired to prepare 250 ce 7% wit, = 250x7 100 = 175 gmof acetic acid. 91. (b) —Theamount of Hydrocortisone required to prepare 60 gm of 0.05%: = 60x0.05 100 = 0.03 gm of hydrocortisone = 30mg of hydrocortisone. 92. (a) Patient weight in kg = 155 ee = 70.43 kg aTReference guide for Pharmaceutical calculations Second Bdition ‘The recommended adult dose of Mezk 250 moglkg/day. 93. (a) preted as 10 gm of drug in 100 cc of solution, therefore 10 in 100 solution is inter- 480x10 100 = 48 gins of povidone iodine, 94. (b) << (25%) 1 By using the alligation method, ‘Total parts 20 (18%) To prepare 20 parts (18%) 7 parts (5%) ‘To prepare 500 cc (18%)? = 500x7 18 = 194.44 cc of Dextrose 5% solution is re- quired. 95. ©) 1 N HCI solution contains 36.5 gm of HCl acid in 1000 ml solution, therefore 0.25 N solution contains = 025x365 = 9.125 gm of HCV1000 ce 1 ‘The amount of HCl acid in 750 ce solution is: viww:pharmacyeram.com Krisman = 9125x750 = 6.84 gm HCl 1000 ‘The purity of HCI acid is 37% wiw, therefore the total amounts of HCI acid required are: = 100x684 37 = 18.49 gm of HCl acid ‘The number of ce of HCl acid required: = 15.41 cc of HCI acid. 96. (@) Aluminum has a gram atomic weight of 27 and valence of 3: equivalent weight = gram atomic weight number of valence ' oR ' © 5 97. (d) ‘The amount of sodium chlo- tide presents in 250 éc of 0.9% NaClis: . = 250x0.9 = 2.25 gmNat 100 7 ‘Total. equivalents Najzpweight in gm 48 ssi signa Weipa stesReference guide for Pharmaceutical calculations Second Edition mEq of Na* = equivalents x 1000 0.03846 x 1000 = 38.46 meq of Nat 98. (©) An equivalent weight of KCL is Equivalent weight= molecular weight number of valence = 145 = 745em 1 Total equivalents of K* = weightin gm equivalent wt Total equivalents of K* = 0.75. gm 745 gm = 0.0100 equivalents of K* mEqofK* = equivalents x 1000 0.01006 x 1000 = 10.06 meq 99. @) An equivalent weight of MgSO, is: Equivalent weight= molecular weight number of valence = 246 = 123 em 2 Total equivalents of Mg"? = weightin gm equivalent wt 50 ce 20% MgSO, solution will contain = 50320 = 10m MgSO, 100 = 10 = 0.0813 equivalents 123 wwwpharmacyexam.com Krisman mEq of Mg = equivalents x 1000 0.0813 x 1000 = 81.30 meg. 100. (d) An equivalent weight of CaCl, will be: Equivalent weight = molecular weight number of valence = ll = 555em 2 ‘Total meq of Ca’? in 480 ce solution are 200, therefore mEq of Ca? = equivalents x 1000 Equivalents = 200 = 02 1000 ‘Total equivalents of Ca’ = weightin em equivalent wt Weight in gm = total equivalents xeq wt = 02%555 = 11.10 gmof CaCl, 101. (©) The gram atomic weight of Aluminum chloride is 106.5 gm/mole. equivalent weight = gram atomic weight number of valence = 1065 2 = 35.5 gm mEq = eqweightinmg 1000 = 35,500 = 35.5 of Aluminum? 1000 49Reference guide for Pharmaceutical calculations Second Edition 102. (b) equivalent weight = molecular weight number of valence = 1SL85. = 75.92 gm/mole 2 mEq of ferrous"? = weightin mg equivalent weight = 225. = 4.28meq. 75.92 103. (a) The amount of sodium bicar- bonate present in a 50% 200 ce sodium bicar- donate solution would be: = 100 grams Total equivalents of Nat = weight in em equivalent wt = 100 = 1.190 equivalents of Nat 84 mEq of Nat = equivalents x 1000 1.19 x 1000 a = 1190.47 meq. 104. (a) —_Each teaspoonful contains 5 meq of K’, therefore the total meq of K* in 1 quart solution is: = 960x5 5 960 meq of K* mEq of Kt = equivalents x 1000 Equivalents of K"= meq of K* 1000 = 960. = 0.96 equivalents of K* 1000 www.pharmacyexam.com Krisman Equivalents = weight in gram ‘equivalent weight Weight in gm= 0.96 x 74.5 = 71.52 gmof KCL. 105. (b) The amount of Na* present in 10% 1 quart solution of NaPO, = 96010 = 96 gm of NaPO, 100 i Equivalent wt = molecular weight number of valence = 164. = 54.66 gm/mole 3 ‘Total equivalents of Nat = weight in gm equivalent wt = 6 17.56 equivalents. ©. 54.66 mEq ofNat = equivalent x 1000 1.756 x 1000- = 1756.31 meq 106. (©) 8.1 meq. seo Equivalent weight= moleculi Weight -* no of valence =74 = 37 gm/mole 4 : 2 Equivalents of Li -weight in'gmi *** ‘ equivalent weight = 03 = 0.0081 equivalents. 37 savbipe E220, equivalents x 1000 0.0081 x 1000 8.1 meq Pei, HCE Ne 50 = shun watReference guide for Pharmaceutical calculations ‘Second Edition 107. (@) The mean blood pressure of Mr.X would be: 180+ +1 = 173.57 mmHg. 108. (@) The sum of probability of sue- cess and failure would be equal to 1 in Null hypothesis and can be expressed by the fol- lowing formula: p+q = 1, where 4= probability of failure 109. (d) —Thedegree of freedom in Chi- square would be expressed by the following formula: R1) x1 (2-1) x (3-1) 110. (¢) — Median or Mode is generally expressed as a middle value of an experiment; if the number of values are even, then the av- erage of middle values should be considered. To find the median or mode of experiment data, one should first arrange the data in as- cending or descending order. Tn our example: 105, 115, 118, 120, 135, 140, 175, 190 = 1204135 = 127.50 2 ‘www pharmacyexam.com Krisman 11. (6) We want to dispense 12 sup- positories each weighing 2 gm and contain- ing 400 mg of tannic acid, Amount of cocoa butter = 2 gmx 12 = 249m Amount of tannic acid = 0.4 gmx 12 = 48 em, Displacement value of tannic acid is 0.9, there- fore: = 4.8 = 5.33 gmof base will displace 09 428 gm tannic acid = 5,33 gm cocoabutter Amount of cocoa butter = 24 gm- 5.33 gm = 1867 gm 112. (a) 33.34gm Amount of cocoa butter= 2gm x 20 Amount of boric acid = 0.5 x 20 = 10gm Amount a boric acid: = 10 = 666gm 15 Amount of cocoa butter = 40 gm - 6.66 gm = 3334gm 113. (a) 42 tablets of prednisone 10mg. 114. (a) The concentration of reactant Mis half in a reaction that is third order in Kinetic: ds = K(@x)b-x)(c-x) at St‘Reference guide for Pharmaceutical calculations Second Edition k(x)? where a=b=c ky now M=M/2 k(MRY Lk (3 8 115. (b) 0.025 min* - For the first order kinetic, K= 2.303 x log C, t c = 2.308 xlog 500 90 50, = 2,303 x log 10 90 = 0.025 min* 116. (c) —_‘Thehalf-life of a drug ina first order reaction is expressed by the following formula: 0.693 k = 0.693 = 10.34 days 0.067 117. (d) K 303 x log Co t ie = 2308 x log 5000 10 500 2.303 x 10 = 0.230 days? ‘eww:pharmacyexam.com Krisman 118. (d) 30.13 minutes. ty = 0.693 = 0.693 = 30.13 minutes. k 0.023 119, (©) 4 times. ax dt = k(@x) (Ox) wherea=b K (ax? where a-x =A ‘k (AY ‘The concentration &f reactant A is double, therefore'we can say A = 2A. = Kay =4k At 120. (d) The half-life ina second order kinetic is éxpre'ssed by following formula: te 7 : aad = 71.42 minutes ‘i * 0.0027 121. (d). 52Reference guide for Pharmaceutical calculations Second Edition = 0.057 min-1 ty, = 0.693 = 0,693 = 12.15 minutes k 0.057 123. (c) 143 years. t = 2.308 x log Co kK c 0 2.308 x log 100 0016 = 10 143.93 years. 124, (b) Vd =M cp = 0.25x10% gm = 2.5x10° 0.1.x 10? gm 125. (a) Patient weight in kg = 156= 70.9 kg os 22 a Mi listribution: =05x709 = 35.45 L f drug is =25x709 =1772.50mg = 1.72 gm Cp = M = LI = 0.049gm1 Va 35.45 = 0.049 mg/ml 126. (a) Tosolvethis problem, we have to first find out the degradation constant: K= 0.693 = 0,693 = 0.191 hour t 3.62 ha www.pharmacyexam.com Krisman K = 2.308 xlog Co t c 0.191 = 2,303 x log 50 12 c C = Smgke. The concentration of drug after 12 hours would be Smg/ee. 127. (b) _Therate of infusion can be cal- culated by the following formula: Cs = _Ri__ where Kx Vd Css = steady state plasma concentration Ri = rate of infusion K elimination constant Vd. = volume of distribution Ri = Cas x 0,693 Vi tn = 20x 0.693 x 15000 4 = 51975 meg/br = 51.975 mgfhr. 128. (c) The loading dose of the drug can be calculated by the following formula: Id = Cssx Vd where: La loading dose Css steady state plasma conc* va volume of distribution 20 x 4500 90,000 meg = 90mg 129, (d) — 25hours = 500 = 25hours 20 53Reference guide for Pharmaceutical calculations Second Edition 130. (@) The status of renal function impairment can be expressed by creatinine clearance. Cees CC: where: a, ‘Total body clearance ice Hepatic clearance Cl, = Renal clearance 2100 = 300 + O, a, 1800 mi/he 30 ml/min ‘The norinal creatinine clearance generally Ties between 80 to 120 mY/min. A creatinine clear- ance in the patient is 30 ml/min, which would be considered severely impaired. 131. © —_Blood_serum freezes at 0.52° C, and all solutions having this freezing point are isotonic with blood serum. 0.9% sodium chloride have the same freezing point as that of blood serum. FP provides by 1% Boric aci FP of blood 7 FP (needed) by NaCl 0.29°C 052 52-0,29) 23°C Now we know that FP provided by 1% NaCl ‘would be, -0.58° C, therefore one can say: For EP 0.58° needs 1% NaCl For FP 0.23° needs 2 = 0.23x1 = 0396 % NaCl 058 0.396 gm of NaCl/ 100 cc. ‘The amount of NaCl needed for 250 cc, = 250x0,396 =0.991 gm NaCl =991 mg 100 www>pharmacyexam.com ‘Krisman 132. (@)__ FP provided by 1% NaClis -0.58° C. To make an isotonic solution we need EP 052°C: 0.58 FP provide by 1% NaCl 0.52FP provide by? = 052x1 = 0.9% = 0.9 gm/100 c¢ 0.58 133, (a) _1% Cocaine solution provides 0.09°C , therefore the amount of sodium chlo- ride required fo produce an isotonic solution would be (0.52 - 0.09 = 0.43), For FP 0.52 » Wenged 0.9% NaCl For fp 0.43 2 = 0.43x0.9 = 0.74 % NaCl = 0.74 g/100ce 0.52 a zs 134, (b) 1% FP of Boric'acid will pro- vide 0.29° and 1% a will provide Cthere- ba 0.29° FP provided by 1% boric’acid 0.398" FP provided 0.398x1 = 137% C 1.29 oa a i 4 ; Bihan aia abencetteatReference guide for Pharmaceutical calculations Second Edition 137. (©) 10 pH = pKa + log salt acid 5 = 4 +logsalt acid Salt = 10:1 Acid 138. @) 10.44 pH = pKw - pKb + log base salt 14 - 456 + log 0.5 0.05 0 z - & $ B9.@ 75 pH = pKa + log salt acid 55 + log 100 1 5542275 140. (a) (0.36% whw Amountof Ointment Amount of HC 15 gm 0.1% (0.1 x 15/100) 60 gm 0.25% (0.25 x 60/100) 80 gm 0.5% (0.5 x 80/100) 0.015 gm 0.150 gm ———2.400gm 155 gmointment contains 0.565 gmHC % HC = 100x0,565 = 0.36% 155 wwrwepharmacyexam.com Krisman 141. (bl) Weave 100 oc of 0.25% Mes- ‘inon solution, therefore we can say: 0.25 gm_/ 100 ce, now this solution is diluted up to 750 cc mark, 25 gm/750 cc .25 x4 gm/750x4 co 143. (9 1.363 mg Patient weight in kg= 150 = 68.18 kg 22 = 20 meg x 68.18 1363.63 meg weekly. 1,363 mg weekly. 144. (©) ‘The amount of sodium hypochlo- rite in 1 quart of 1 in 500 solution would be = 960x1 = 1.92 gm 500 ‘We have 0.75% stock solution, therefore the amount of stock volume needs to be 1.92 gm sodium hypochlorite. = 100x192 = 256 cc 0.75% solution 0.75 145. (c) 1 gmof cefazolin is reconsti- tuted with 12.5 cc of SWFI and the resultant solution is inserted into 50 cc of 0.9% NaCl. ‘We can say that 1 gm of cefazolin is present in 62.5 cc (50 + 12.5) of solution: = 1 gin 625 cc (50 cc + 12.5 ce) 55Reference guide for Pharmaceutical calculations Second Fdition = 1000 mg in 62.5 cc = 16mg/cc 146. (@) parin solution, ‘We have 5000 units/10 cc he- 5000 units/10 ce = 500 units/ee =2.x 500 units = 1000 units will be injected into 100 ce of D,W solution. (000 units in 102 ce (100 ec + 2.ec) .80 units/ec. 147. (b) The LV. admixture contains 1000 mg/250 ce solution and should be fin- ished within a 5 hour period. 250 ce in 300. min 83 ce / min. N, set delivers 20 drops per ce 20 dropsice 16.66 drops/0.83 ce 16.66 or 17 drops/min 148. (c) We have 250 mg/500 cc theo- phylline solution: = 250 mg/500 cc 250000 meg/500 ce 500 megfee’ 149. (©) We have 250 mg/500 ce of Rocephine solution, Patient weight in kg = 155 = eee 04S kg 5 meg/kg/min = 1.5 meg x 70.45/min = 105.68 meg/min = 0.105mg/min vwww.pharmacyexam.com Krisman ‘We have 250 mg/500 ce Rocephine solution, = 250 mg/500 ce 0.5 mgfec = 0.105 mg/0.211 ce 0.105 mg=0.211 cc = 1 min, therefore we can say: = 0.211cc/min. 150. (@) Earlier in this book we dis- cussed a number of mEq problems, here is another method to solve the mEq problems.’ Eq weigh = molecular weight number of valence 74.5 gm = 74.5 gm/ mole 1 equivalent of KCI = 74.5 gm of KCL ImEgofKCl = 745mg of KCI ‘The amount of KCL in 20 ce of 10% solution: = 20x10 = 2gmKCl = 2000mg KCI 100 2000 mg KCV/270 ec (250 + 20) 7.40 mg KCl'ce Now] mEq=74.5 mg of KCL = 1,40 = 0.099 megee 5 “ 56 aaaReference guide for Pharmaceutical calculations Second Edition = 84gm/mole = 84 gm i 1 equivalent = 84 gm sodium bicarbonate ImEq =84mg sodium bicarbonate mEq of Na* = 96000mg.= 84mg 1142.85 152. (©) Thenumber of mEq of KClin 20 ce (4 mEq/ec): = 20x4 = 80 mEq of KCL Equivalent wt = molecular weight number of valence = T4Sgm/mole = 74.5 gm 1 1 equivalent of KCI 1 mEq of KCI 745 gm 745mg = 80x74.5 mg = 5960 mg = 5960 mg/250 ce = 23.84 mgice 153. (d) The number of mEgq present in 120 ce solution (10 meq/5 cc): = 12010 = 240meq of KCL 5 1 meq of KCl = 74.5 mg of KCI, Milligram of KCI; = 240x745 mg www:pharmacyexam.com, Krisman 17880 mgof KCL 17.88 gmof KCI 154. (A) The amount ofPovidoneingm in 10% 1 1b ointment is : = 10454 = 45.4 gm of povidone 100 ‘The ce of povidone required: = 45.4 gm = 22.7 cc of Povidone 2 gm/ce 155. (c) The amount of Triamcinolone in 1% of 1 Ib ointment: = 454 = 4.54 gm of triamcinolone 100 2. iameinol = 454gm+50gm = 9.54 gm of triamcinolone. 12 % of tri final = 100x954 = 2.1% whw 454, 156. (©) The amount of HCI acid re ‘quired to prepare 1 gallon of 2.5% HICl ist = 3840x2.5 = 96 gm HCI acid na 100 ‘The purty of HCl acid is 35% wh, sow et 96 gm of HCl, we need = 96100 = 274.28 gmof HCL aE 35 ‘TheVolume of HCI acid needed to. prepaye 274.28 gm of HClis: = 27428em = 219.42 ml of HCL 1.25 gm/mi wT.Reference guide for Pharmaceutical calculations Second Edition 157. (d) _ %ofelementary iron in 325mg of ferrous sulfate: = 65.5100 = 20% whw 325 158. (d) To solve this problem, we should use the alligation method, Oy + Ig) Tigo wil spread on water, but not vice versa. 236. (b) The velocity of creaming can be calculated by the following formula: v = @@ -P) g* = 1.3080 10%.emisee : 237. (a) —_Milliogmols'céni be calculated by the following formula mOsomol/lit 68Reference guide for Pharmaceutical calculations Second Béition Since dextrose is nonelectrolyte, the number of species should be considered as 1. We have 500 ce D25W solution, therefore: 25 gm/100 cc = 250 gm/1000 cc = 250x1x 1000 180 = 1388.88 mOsm/L, = 138.88 mOsm/100 co 238. (a) The osmolarity of sodium bicarbonate solution can be calculated as follows: 25 gm/L00 ce = 250 gm/1000 ce ‘The number of species = 2 = 250.x2x1000 = 5952.38 mOsm/L 84 239..(a) We have 50 oc 20% Calcium chloride solution: 50x02 = 10 gm, 10 gm/SOco = 20 gm/100 ce = 200 g/L. CaCl, = cet ec A number of specises for CaCl, should be 3. = 200x3x1000 = 5405.40 mOsm/L in 240. (b) To solve this problem we should use the alligation method: an & 28%) ‘Total parts 56%) www>pharmacyexam.com Krisman ‘To prepare S parts (5%) 3 parts (3%) To prepare 100ce (5%)? = 100x3 = 60 ce of 3% boric acid 5 241. (c) 297.61 mEq Equivalent wt = 84 gm/mole = 84 gm 1 1 equivalent of NaHCO, = 84 gm 1 mEq of NaHCO, = 84 mg tity of , mEq of Na* = 25000 = 297.61 mEq of Nat 84 242. (c) 6.25 meglee it of = 5x30mg = 150 mg. ‘This 150 mg will be present in 240 co of solution therefore: = 150 mg/240 ce 30.625 mgfeo 10 cc (6.25 mg) of this resultant solution is diluted up to 1000 ce: = 6.25 mp/1000 co = 0.00625 mg/ec = 25 meglee 69Reference guide for Pharmaceutical calculations Second Edition 243. (b) 307.69 mOsm mOsml/E, =wt (g/L x no. of species x 1000 mw (g) Amount of NaCl; 200 x 0.009 gm 1.8 gm/200 co = 9mg/1000 ce wu = 9x2x 1000 58.5 = 307.69 mOsm 244. (©) 2684.56 mOsm/L. of Ke =30x0.1 =3 gm KCV/30cc = 2684.56 mOsm/L. 245. (d) 2.77 drops/min ‘We have to infuse 100 co/250 mg Rocephine via LV. infusion over a 12 hour period: 100 co/12.x 60 minutes 0.138 cofmin LY. set delivers 20 drops/ee: 20 dropsice 2.77 dropsi0.138 ce ‘www pharmacyexam.com Krisman = 2.77 drops/min 246. (d) 22.91 drops/min We need to infuse 20 ce + 50 ce + 30.cc-+ 1000 ce = 1100 ce within 8 hours, therefore, 1100 cel8 x 60 2.291 ccfmin LY. set delivers 10 dropsiec, 10 drops/ec 22.91 drops/2.291 cc 22.91 drops/min 247. @) 8.33 hours ‘We want to infuse 500 ce DSw solution with a flow rate of 20 drops/min. The LV. set delivers 20 drops/ce, therefore one can say: 20 drops/min 20 dropslee or Lee / min ¢ ‘Time required to complete the infusion: = 500 cc/I = 500 minutes = 8.33 hours (248, (b) 18.75 drops/min Flow rate of solution drops/min: 300 cc /4. x 60 minutes 25 eclmin LV. set delivers 15 drops/cc therefore: 70Reference guide for Pharmaceutical calculations Second Edition A normal therapeutic dose in mg is 10 mg/ kg/day: 10x 70.45 mg 704.5 mg, wo ‘The number of LV, infusion bags: = 704.5/250 = 2.82 = 3 bags 250. (a) — 1in 100isinterpretedas 1 gm of dextrose solution in 100 cc: Amount of dextrose: 50/100 05 gm www-phamacyexam.com Krisman 1‘How many milligrams are present in 1/150 gr Nitrostat tablet? a 12mg b. 0.43 mg c 45mg 4 35mg 2. How many 1/200 gr of tablets can be prepared from 500 mg of active ingredient? a 167 b. 432 c 1538 d 1100 3. How many milligrams of Guiafenesin will be present in 480cc (15 mg/5 cc) of solu- a 908mg b. 1440mg ce. 100mg 4 521mg 4. _ If the retail cost of each Zyprexa tab- let is $2.40, what would be the retail cost for 30 tablets? 2 un 24 7 pose 5. How many grams of dextrose are re- quired to prepare a 1000 cc Dw solution? a 125gm bo 15m ce 50gm 4 500gm 6. How much atropine is required to pre- pare @ 1:500, 500 ce solution of atropine ? www>pharmacyexam.com PRACTICE TEST Krisman a 0.5 gm b. 0.005 gm e 10gm a igm 7. How many grams of Lidocaine are re- quired to dispense 1 quartof 1 in 50 solution? 114 gm Sem 19.2.m 21gm -P pooe How many calories are provided by 1 quart of a 1 in 500 solution of dextrose? 11.2 calories 9.55 calories 55.6 calories 6.53 calories aooe 9. How much Xylocaine is required to prepare 30 cc of a 1:500 solution of Xy- locaine? a 120mg v. 90mg c. 60mg 4 30mg 10, In what proportion should 49% alco- hol be mixed with water to prepare 1000 cc of a 25% alcohol solution? a 305ce b 810 e& Mlee ad 5102cc 1. How much Heparin is required to dis- pense a 0.25% 750 cc solution? a. b. es a 2 etdReference guide for Pharmaceutical calculations Second Edition 12.. If. prescription calls for “Biaxin 500 mig po bid x 10 days”, how many cc of Biaxin 125 mg/S ce are required to dispense a 10 day supply? a 200ce b.” 100ce c 400ce da 50ce 13, _ Ifa prescription is writton,to take 50 mg of diphenhydramine by mouth four times a day for 5 days, how many cc.of 12.5 mg/5 cc diphenhydramine solution are required to dispense 5 day supply? a 400ce bee c. 80ce a. 10¢e 14. If 125 meg of a drug are diluted with ‘water up to 50 ce, what is the % of drug ? a 0.25% b. 125% ce. — 0,00025% 4. 0,0025% 45. If 1 tablospoonful of Thioridazine in- tense solution (100 mg/cc) is diluted with wa- ter up fo 1 quart, what is the % of drug in the final solution? a 1.25% b. 0.005% c. 0.156% a 275% 16. If 10 teaspoonfuls of Risperdal oral so- ution (100 meg/5 cc) are diluted with water up to 480 cc, whats the concentration of drag, in meg/ce in the final solution? veww.pharmacyexam.com Krisman a 1.2 meg/ml b. 2.5 mg/ml c. 2.083 meg/ml 4.5.10 meg/ml 17. _ How many cc of 10% Benzoyl perox- ide are required to prepare a 5% 20 cc Ben- zoyl peroxide solution? a 10ee b. 50ee c. 25ee d— 100ce. 18. How many milligrams of Clindamy- cin are present in 60 cc of 0.1% topical gel of clindamycin? a 100mg bd. 30mg c. 60mg a 45mg 19. How many tablets of 250 mg erythro- mycin are required to prepare 500 cc of 2% topical solution of erythromycin? a 10 b. 40 cc © 80 a 0 20, If 325 mg of ferrous sulfate contains 22% elementary iron, how many milligrams ‘of elementral iron will the patientreceive with each dose? a 20mg b. 60mg 715mg ad 50mg 21. If niferex liquid solution provides 10 mg of elemental iron in 1 teaspoonful, how many ce of solution are required to provide 59 mg of elementral iron ? BReference guide for Pharmaceutical calculations Second Edition a 27.5 cc b 12.5¢e c. 25.0cc a 305ec 22. £30 gmof0.19Triameinotone cream are mixed with 70 gm of 0.25% Triamcino- ‘Tone cream, what is the % w/w of Triamcino- lone in the final mixture? a 0.15% b. 0.005% c 0.205% 4 0.27% 23. Ifa prescription reads decanoate IM. every week”, of Haldol decanoate (10 mg/ce, 5 cc) are re- quired to dispense 130 day supply of the drug? peo 24, vials 1 vial 2 vials 10 vials If 1000 tablets of Zyvox cost $8550, and the mark up on the prescription is 15%, ‘what would be the retail price of 30 tablets? Bo oP 25. $294.97 $125.10 $312.5 $111.12 ‘How much betamethasone is required to prepare 80 gm of 0.05% ointment ? pose 25 mg 145 mg 40 mg 75mg wow pharmacyexam.com Krisman, 26. If the ratio of ionized to unionized is 10 and pKa = 3, what is the pH of the solu- tion? Bose Bowe 27. _ If a prescription calls for “Amoxicil- 4in 500mg by mouth twice a day for 10 days”, bow many cc of Amoxicillin 125 mg/5 cc are required to dispense a 10 day supply? a 400ce b -200ce ce — 100ce 4d 30ce 28, What is the weight in grams of 50 cc of glycerine having a specific gravity of 1.25 gm/ee? a 40gm ’. 25em c 0.025 gm i: & 625 em 29. What is the volume of 10 Ibs of chlo- roform having a density of 1.5 gm/ml? a, 3026ce db 12320 456 ce 585 ce a 30. How many milliosmolV/U ate repre- sentated by 1000 cc 0.9% soditinichloride?Reference guide for Pharmaceutical calculations Second Edition [Ka = HO" x CHCOO*] (CH,COOH a 1.256510 b. 25x 106 c 32x10 da 45X10* 142. The measured solubility of sodium. chloride in water at 25°C is 0.1 x 10° mole/ liter. Whatiis the solubility product of this salt? [NaCl is a strong electrolyte and completely dissociates so use Ksp = [Nat] x [CI] a 0.1x10* b. 0.1.x 107 ce 15x10 a. 0.01x10* 143. What is the solubility of silver chro- ‘mate in mole/liter in an aqueous solution con- taining 0.5 M of silver nitrate? The solubility of Ag,CrO, in water is 5 x 10% and KSP is equal to 5.x 105. a 20x 10 b. 2x104 ce 25x10% ad -12x10* 144, How many milliosmols per 100 cc are represented by a 5% 250 cc KCI solution? [mw of KCl = 74.5 gm/mole] a 101.43 bested erao6a4 da. 1342.22 How many milliosmols/L. are repre- sentated by 50 ce of a 5% sodium bicarbonate solution?[mw of sodium bicarbonate = 84 gm/ mole} weww:pharmacyexam.com Krisman a 1234.34 b. 2012.52 c 1190.47 a 560.13 146. In what proportion should 25% aleo- hol be mixed with water to prepare 750 cc of 12% alcohol solution ? a 15060 b. — 600ce ce. | 365ec da 360ce 147, How many milliosmols per liter are representated by 150 ce of 0.25% aluminum chloride solution? [mw of aluminum chloride = 135 gm/mole] a 74.07 b. 12.56 cs 13211 d 435.09 148, How many milligram of lidocaine are required to prepare 1:15000, 100 cc solution? a 125mg b 6.66 mg ce 321mg a 1009mg 149, Calculate the flow rate in drops/min. ‘The LV. set infused 400cc of Clindamycin so- lution over a 6 hour period. [LV. set delivers 20 drops/ec] a. 22.22 drops/min b. 12.5 drops/min cc. 10.25 drops/min d 8.6 drops/min 150, How many milliosmols/L are repre- sentated by 30cc of 1% CaCl, solution? [mw = 111 gmv/mole] 87Reference guide for Pharmaceutical calculations Second Edition a MLZ b. 270.27 c 3015 ad 56723 151, Therecommended therapeutic dose for Levaquin LV. is 7 mg/kg/day. The drug has an elimination half-life of 12 hours and the ‘volume of distribution is 1.2L/kg. What would be the plasma concentration of the drug? [ pa- tient weight = 170 Ibs] ‘What would be the initial plasma con- centration of drug in mg/ml ? {use V, = M/C, } a. © 10.11 meg/ml © 23.12 meg/ml ce, 5,833 meg/ml 4, 33.23 meg/ml 152. _ Referring to the above question, what would be the elimination constant? a 1.2x10%hr b. 3.5x107hr ce. 0.0S7Thr 4. 0.980x 109 hr 153. The recommended steady state plasma concentration of Cipro is 20 meg/mil. If the rug has an elimination half-life of 6 hours and the volume of distribution is 0.5 Likg, ‘what would be the rate of infusion in mg/min? [patient weight = 155 Ibs] a 2.25 mg/min b. 5.60 mg/min 1.35 mg/min aL. mg/min 154, Referring to the above question, what should be the loading dose of Cipro in the patient? www,pharmacyexam.com Krisman a 112.12 mg b. 209.89 mg ce. 704.54mg a 453.29 mg 155. How many grams of dextrose are re- quired to dispense 1 gallon of 1 in 500 solu- tion? a 123gm b. 10.9 gm c © 256gm 4. 7.68 gm 156. How much Lidocaine is required to prepare a 1:30,000, 50 cc solution? a 589mg b. 2.23 mg ©. 1.66 mg 4.» 10.98 mg 157. In what proportion should 10% sali- cylic acid be mixed with white petrolatum to dispense 500 gm of 4% salicylic acid? a 105gm b 400gm G 200 gm d—-160.gm 158. How much heparin is required to pre- pare 1 pint of 1.25% solution? a 125gm b. 250m c. 6am 4 12gm 159. If 1000 tablets of Zyprexa cost $4550 and the mark up'on piesciiption is 20%, what ‘would be the retail price’ for 90 tablets? a,» $123.24 vb. <$30213 88Reference guide for Pharmaceutical calculations Second Edition ce. $560.09 ad $491.40 160, How much sodium bicarbonate is re- quired to prepare a 250 cc 0.3N NaHCO, so- lution? a 12m b. 2.5 gm c. 63m a idgm 161. Find out the ratio of ionized to union ized drugs at pH = 5.5. The pKa of dng is 2 a 1:100 b. 10:10 c. — 1000:1 da 1:50 162. How much sodium hydroxide is re- quired to prepare 500 ec of 0.4 NNaOH solu- tion? [ mol wt = 40 gm/mole] 4gm 6 gm 8am 2em pose (Hint: The simple way to solve this kind of problem is. According to definition of Normality (N) 1000 ce 1 N solution contains 40 gm NaOH 1000 ce 0.1N solution contain 4 gm NaOH 1000 ce 0.4N solution contains 16 gm NaOH 500cc 0.4N solution contains 8 gm NaOH] 163, How many ce of HCl acid are required to prepare 750 cc of 0.15N HCl acid solution? [mol weight HCl = 36.5 gm/mole, purity of HCl is 37% w/w, density 1.2 gin/ml] wwv.pharmacyexam.com Krisman a 11.09 ce bd. 924ee c 4.10 cc a 20.1 ce 164, How much sodium hydroxide is re- quired to prepare a 250 cc 0.05MNaOH solu- tion? [mol wt = 40 gm/mole] a 05gm b L6gm ce 28gm a 3.1gm 165. How many calories are provided by 1 pint of 2.5% dextrose solution? a. 40.8 calories b. — 12ealories ¢. 60 calories d 121 calories 166. 1000 cc of TPN solution should be in- fused over a 12 hour period. If an LY. set de- livers 20 drops/cc, what would be the flow rate in drops/min? a 27.77 drops/min b. © 21.12 drops/min c. 13.5 drops/min 9.09 drops/min 167. _Areconstituted solution of Rocephine 500 mg (250 ce 0.9% normal saline) should be infused over a 4 hour period: If an LV. set delivers 15 drops/cc, what would be the flow rate in drops/min? a, 15.62 drops/min b. 11.10 drops/min c. 21.20 drops/min 34.5 drops/min 168. How long will it take to infuse 500 ce of 500 mg Levofloxacin solution with a flow rate of 25 drops/min? [An LV. set delivers 15 dropsec] 89Reference guide for Pharmaceutical calculations Second Edition a. Shours b. 3 hours ce. — Lhour 4. 2hours 169. If the recommended therapeutic dose for Cipro is 10 mg/kg/day, How many milli grams of drug will the patient receive every 6 hours ? [patient weight = 150 Ibs} a 170.45 mg b. 525.1mg c. 210.80 mg 4 903mg 170. In what proportion should 5% hydro- cortisone be mixed with cold cream to dis- pense 60 gm of 3% hydrocortisone cream? a 12gm b. 36gm ce — 50gm a 10gm 171. _ Laprescription calls to dispense I pint of KCI solution in such a way that each tea- spoonful of solution contains 10 meq of KCI, how many milligrams of KCI are required to dispense the above prescription? [mw = 74.5 gn/mole] a. 30.89 gm bos 7152gm ce.) 12.67 gm a -21.20gm 172. How many milliOsmols/L are repre- sentated by a 0.25 % AICI, solution? [mol weight AICI, = 135 gm/mole] a 32.11 b. 52.34 c 1407 4. 11.09 www.pharmacyexam.com Krisman 173. If a prescription is written to com- pound a TPN formulation such a way that 55% ‘03500 calories are provided by fat, how many ce of 10% emulsion are required? a 123400 b. 2341 ee ce — 1750ce ad 436cc 174, Ifa prescription calls to provide 1000 calories as dextrose and the maximum volume of dextrose that can be infused is limited to 2500 cc, what would be the strength of dex- trose in % w/v? a 25.12% b. 50.09% ce. 30.87% ad 11.76% 175. How many calories are provided by 2000 cc of 2% amino acid solution? a 345 calories b. 900 calories c. 120 calories d. 160 calories 176. low much heparin is required to dis- pense 240 ce of a prescription such that 1 tea spoonful of solution dilutes to 1 pint gives a lin ‘500 solution? a 67.89 gm b. 46.08 gm c. 34.55 gm @ 12.22gmes Hint: To sletinkindefrben, goback- ward, i ne cei a pi aniReference guide for Pharmaceutical calculations Second Edition Step 1 An amount of drug in 1 pint: 500cc solution contains 1. gm heparin 480cc solution contains? = 480/500 = 0.96 gm heparin, These amount of drug must be present in 1 teaspoonful of solution, therefore one can say that each 5 cc of solution will contain 0.96 ‘gm of heparin, We want to find out the aniount of heparin in 240cc of solution, Sce solution requires 0.96 gm 240 ce solution will require? = 0.96 x 240/5 = 46.08 gm heparin. 177, How much atropine is required to pre- pare 12 oz of solution such a way that I table- spoonful dilutes to a quart that will make a 1 in 2000 solution? a 11.52 gm b.-21.23 gm c 34.67 gm 40.90 gm 178. How much lidocaine is required to pre~ pare 10 oz so that 2 teaspoonfuls are diluted to 2 quarts will make 0.05% solution? a 5.50 gm b. 90.6 gm ce. 288 gm 4 345gm 179. How many tablets (each weighing 500 mag) of erythromycin are required to prepare 1 quart of 1 in 50 solution? a, 12 tablets b. 39 tablets ce, — Stablets d 55 tablets ‘www/pharmacyexam.com Krisman 180. How many tablets (each weighing 1/2 grains) of phenobarbital are required to pre- pare an 8 oz solution such a way that each ‘teaspoonful of solution contains 5 mg of phe- nobarbital? a. 90 tablets b. 8 tablets c. 25 tablets d 55 tablets 181. How many milliequivalents of KClare present in 1 gallon of 1 in 5000 solution? [mw of KC1=74.5 gm/mole] a -23.4meq b. 55.9 meq ce. 10.3meq ad 1.23 meq 182. How much sodium bicarbonate is re- quired to prepare 12 07.s0 that each teaspoon- ful of solution contains 2.5 meq of Na ions ? [mw = 84 gm/mole] a 10.89 gm bd. 34.56 gm c 43.12gm a 15.12. gm 183. How many milliequivalents of Na* ion are present in 1 gallon of 0.45% NaCl solu- tion? [mol weight = 53.5 gm/mole] a U1 meq b. 323meq ce. 212meq 4 456:meq 184, ‘The recommended therapeutic dose of Diflucan is 10 mg/kg/day by an intravenous route. What would be the flow rate in drops/ minutes if an LV, set delivers 20 drops/ec. {patient weight = 170 Ibs, diflucan 100 me/ 100 ce D,W bags are available in stock.) o1Reference guide for Pharmacentical calculations Second Edition 10.73 drops/min 21.23 drops/min 34.56 drops/min 9.08 drops/min apse 185. How many milliOsmols/100 ce are representated by 500 ce 0.5% Na,PO, solu- tion? [mw of Na3PO4 = 259 gm/mole} 1.23 mOsmol/100 ce 5.67 mOsmol/100 cc 7.72 mOsmol/100 ce 21.3 mOsmol/100 ce aese 186. How many grams of cocoabutter are required to dispense 20 suppositories of tan- nic acid each weighing 2 gm and containing 500 mg of tannic acid’? [DV for tannic acid = 0.9 a 12.34gm. b. 28.88 em ce 7.99 gm 4 45.67 gm 187. How many grams of sodium chloride are required to prepare 500 ce of 1% boric acid and cocaine hydrochloride (1%) solution iso- tonic with blood? FP of 1% boric acid = -0.29°C FP of 1% sodium chloride = -0.58°C FP of 1% cocaine hydrochloride = -0.09°C 34.59 gm 1.21 gm 24.13 gm 11.20 gm apse 188. When radioactive iodine decomposes to 10% of its original concentration (100%), it should be labeled as expired. Ifa drug has a half-life of 1.3 x 10° months, what would be suggested expiration date? www.pharmacyexam.com. Krisman, a. 12 months b. 432.08 months ¢. 35.67 months d. 111.12 months 189, 175 ccof potassium permanganate so- Tution 2gmv/L) are diluted with water up to a 100 cc , and 10 ce of the resultant solution are diluted with water up to 1000 ce. 7.5 cc of this resultant solution are diluted with water up to 50 cc, what would be the final concen- tration of drug in meg/ml? a. 0.015 megfee b. 15 megiec c. 0.15 megiee d. 150 megiee 190, If 10 gm of Cipro dry powder for oral solution are diluted with purified water up to 200 ce, how many mg of drug would be present in each teaspoonful of solution? a 125mg b. 500mg c. 1000mg 4. 250mg 191. Ifa prescription calls for the addition ‘of 170 cc of purified water to make 200 ce of oral solution such that each teaspoonful of so- Iution contains 75 mg of Biaxin, how many grams of drug are required? a 3gm b Sem ce 10gm a igm 192. Ifaprescription calls to prepare 120ce ‘NaF solution such that when 1 teaspoonful of solution is diluted to 1 glassful of water a3 ppm solution results. Calculate the weight of ‘NaF required to prepare above the prescrip- tion.Reference guide for Pharmaceutical calculations Second Edition a: 11.23mg b.-17.28mg c 15.50mg a 5434mg Hint: This problem should be worked “back- wards”, 3 ppmis interpreted as 3 gm of solute present in 1,000,000 parts of solution. 1 glassful of water (240 ce) must contain 3 ppm of NaF therefore we can say : 1,000,000 solution contains 3 gm of NaF 240 cc solution will contain ? =3 x 240/ 1,000,000 = 0.00072 gm NaF Now this 0.00072 gm NaF in the glass came from a teaspoonful dose, therefore each tea- spoonful (5 cc) will contain 0.00072 gm NaF, ‘The 5 cc came out of the original prescription order bottle (120cc), therefore Sec solution requires 0.00072 gm NaF 120 ce solution will require? = 120x0.00072/5 0.01728 gm 17.28 mg of NaF ‘Sometimes the physician prescribed the con- centration in terms of FI ions. Referring to the above calculations if a pre- scriber orders 3ppm solution in terms of Fl- ion concentration, we have to add a few more. steps: ‘The molecular weight of NaF is 42 and the atomic weight of FI'is 19, wow pharmacyexam.com - Krisman To get19mgFt we need 42. mg NaF ‘To get 17.28 mg Fl? 17.28 x 42/19 = 38.19 mg NaF 193. _ If the prescription calls to prepare 240 cc NaF solution such that when 1 teaspoonful of solution is diluted to 1 glassful of water a5 ppm concentration of fluoride results. Calcu- late the weight of NaF required to prepare the above prescription, 201.90 mg 127.32 mg 57.60 mg 109.8 mg po oe 194, If the prescription calls to prepare 1 pint of NaF solution such that when 2 tea- spoonfuls of solution are diluted to 1 glassful of water a 2 ppm solution results. Calculate the weight of NaF required to prepare the above prescription. 34.56 mg 89.76 mg, 23.04 mg, 12.33 mg 195. Convert 80°F into °C. a 12.53 b. 45.60 ce. 26.66 4 78.90 196. Convert 25°C into °F. a 54 bide fete, en, 93Reference guide for Pharmaceutical calculations Second Edition 197. How much sodium bicarbonate pow- det is required to prepare 120 ce of 0.05 N solution of NaHCO, ? {mw = 84 gm/mole} a 123mg b. 504mg c 324mg 4. 56mg 198. How many cc of TPN solution can be administered within a 6 hour period if the flow rate of infusion is 25 drops/min? ILV. set delivers 10 drops/ec} a 900ce b. —1100ce c — 500ce a 250ce 199. How many total calories are provided by a TPN solution that contains 1000 cc of D3OW, 500 ce of 10 % fat emulsion and 250 ce of 5% glycerol ? 1624 calories 2100 calories 500 calories 109 calories pesos 200. Calculate the ratio of unionized to ion- ized drugs having a pH of 8. [pKb = 10] a. 10,000:1 b.1:100 ce. 10:1 4. 100:10 201. How many grams of Dextrose are re- quired to prepare 1000 cc DS0W solution? a 250gm b. 750 gm ce. 500gm & 1000 gm www-pharmacyexam.com Rrisman’ 202, How much Physostigmine is required to prepare 1:10, 31. of solution? a. 100 gm b. 150gm ©, 450 em. a 300gm 203. How many ce of 0.25% KMnO4 solu- tion should be mixed with 0.1% KMn04 so- lution to prepare 0.15% of 1000 ce KMnO4 solution? a -334cc b. 6 ce ce. — 852cec d 521ee 204, If 500 mg of Cephalexin powder are . 50gm ce Sgm a 75gm 231, How many grams of sodium chloride are required to prepare 500 cc normal saline solution? 2.3 gm 9.0 gm 12m 45 gm aeee www. pharmacyexam.com Rrisman 232. How much Lidocaine is required to prepare 100 ce 1:10 solution? a. 10 grams bd. S grams ce. 15 grams a 75 grams 233. What is the % of Dextrose in 1 in 50 solution? a2) es) conaeed: deuaaes, 234, To dispense 10% of 500 cc solution of sodium bicarbonate, how many pints of 40 mg/ ce are required? a 35 b 42 eet a 26 235, If 15 cc of Thioridazine (30 mg/cc) are diluted with water up to 480 cc mark, what ‘would be the strength of drug in mg/ec? a 0.94mg/ee b. 1.2 mg/ec ce. 2.22mg/ee a 0.64 mg/ee 236. How much KMn0, is required to pre~ pare 4 oz in such way that when I teaspoonful of solution is diluted to 1 quart, it gives 1 in 1000 solution? a 12.55 gm b. 15.60 gm c 23.04.gm 4 3211 gmReference guide for Pharmaceutical calculations Second Edition 237. . How many vials of Ativan 2 mg/2 oc are required to prepare 4 pints of 0.05% solu- tion? 22120 b. 360 c 480 a 600 238. How many grams of 0.25% Clobetasol ‘ointment can be prepared from 1 gram of an active ingredient? a 100 b. 250 e350 da 400 239, How much sodium chloride powder is required to prepare 250 cc of 0.2N solution? (mw of NaCl = 58.5 gm/mole) a -2.92.gm b.1.53gm c. 3.63 gm 4 -423.9m 240.:: How many cc of concentrated HCI acid are required to prepare 1000 cc 0.1 N acid solution?(mol weight = 36.5 gm/mole, purity 37% ww, density 1.2 gm/ml) a -3.12ee b. 4.26 ce e . 5.15 e¢ d 821cc 241. If 30 gm of of 1% Hydrocortisone is mixed with 70 gm of 0.25% Hydrocortisone, what would be the % of Hydrocortisone in w/ win the final mixture? a 1.2% whw b. 0.475% wiw c. 0.893% wiw da 2% wiw www.pharmacyexam.com Krisman 242, If 1 pint of 20% alcohol is mixed with 2 quarts of 30% alcohol, what would be the % of alcohol in v/v in the final mixture? a 21.23% viv b. 15.6% viv 312% & 28.00% viv 243. How many grams of 2.5% w/w ‘Hydrocortison should be added to 100 gm of 1% whw Hydrocortisone to prepare 200 gm of 1.5% w/w Hydrocortison? 2 66.66 gm b. 121.21 am c. 32.42gm ad 42.5gm 244... How many ce of D,W solution are re- quited to prepare 500 ce D,,.W solution? a 1250ce b 5000 cc c 3500 cc 4 4200.ce 245, Ifa patient takes 0.325 mg dose of the drug per day, what would be the recommended dose of the drug in meg/kg/day? (weight = 143 Tbs) a 10 meg/kg/day b. 5 meg/kg/day c. 20 megikg/day d —- SOmeg/kg/day 246. Ciloxan optiialamic solution is avail- able as 0.3% w/v, How many mg of drug are required to prepare 5 cc? a 15 mg b. 25mg e. 105mg a 220mg 98 q eeReference guide for Pharmaceutical calculations Second Edition 247. A prescription for Betaxolol reads as follows: Betaxolol 0.05% eye drop Sig: 1 git od gid x 7days How many milligrams of Betaxolol are present in each drop of the solution? (1 drop =0.1 ec) a 0.10 mg b. 0.15 mg ce. 025mg a 0.05 mg 248. How many micrograms of Lanoxin are present in 120 cc of 0.5% Lanoxin elixir? 06 x 10° meg 0.1.x 10! meg, 0.5 x 10° meg 0.9 x 10” meg apse 249. 1 gmof Cefazolin is reconstituted with 100 cc 0.9% NaCl. It is given via slow LV. infusion over 8 hours. If the LV.'set delivers 20 drops/ec, what would be the rate of flow in drops/min? a, 4.16 drops/min b.$.23 drops/min cc. 6.12 drops/min a 1.32-drops/min 250, [fan adult dose of Amoxicillin is 500 mg, what is the dose of the drug in a patient having a 145 mun? body surface area? a 409.18 mg b. 521.11 mg ce. 311.16mg d, 419.07 mg 251. How-many grams of Hydrochloric acid are required to prepare 250 cc of 0.5 N HCI? (mw = 36.5 gm/mole, density = 1.2 gm/ml, putity of HCl = 37% ww) www.pharmacyexam.com Krisman a 1233.gm b. 13.21 gm ce S.igm a 8.26 gm 252,. How many meq of K* are present in 750 mg of KCI? (mw of KCI =74.5 gm/mole) a 11.12meq b. 12.13 meq ce. 14.21 meq ad 10.06 meq 253, How many meq of Na’ are present in 50 ce 5% NaHCO3 solution? (mw = 84 goa! mole) 10.11 meq, 45.10 meq 29.76 meq 13.11 meq aoee 254, How many meq of Ca”? are present in 50 grains of CaCl, powder? (mw of CaCl, = 111 gm/mole) 102.11 meq, 32.21 meq 24.12 meq 58.55 meq ees 255, How many meq of Mg” are present in 250 cc of 1% MgSO, solution? (mw = 246 gm/mole) a 12.11 meq b. 41.12 meq c. 35.12 meq 4-20.32 meq 256. How many grams of MgSO, are re- quired to prepare | pint solution that contains 250 meq of Mg”? (mw = 246 gm/mole)Reference guide for Pharmaceutical calculations Second Edition a 15.25 gm b. 80.1 gm ce M1113 gm a 30.75 gm 257. How many meq of Al* are present in 250 cc 0.05% AICI, solution? (mw = 106.5 gm/mole) a 4.18 meq b. 7.21 meq ce. 3.52meq a L.1hmeq 258. How many grams of Na,PO, are present in 1 quart solution contains 5 meq of Nat ions in one teaspoonful of solution? (mw: Na,PO, = 164 gm/mole) a 23.1. gm b UL1S gm ce 5248 am 4 102.21. gm 259, How many meq of Li* are present in ‘450 mg tablet of Li,CO,? (mw = 74 gm/mole) a 10.11 meq b. 31.10meq ce. 14.13 meq a 12.16 meq 260, Mrs. X has the following blood glu- cose values: Days Mgidl Mon 125 Tue 180 Wed 175, Thu 164 Fi 101 Sat 132 Sun 180 www.pharmacyexam.com Krisman ‘What is the mean blood glucose? aaa v.14? ec ISL a 185 261, Whats the “mode” or “median” of the following values? 9, 11,7, 3, 13, 15,8, 17,21 eed) bBo cee. ase 262. How long will it take to decompose ‘Atropine to one half of its original concentra tion? (cate of constant = 0,138 hr) a 5.02hr b 10.11 br c 7.14 br 4d. .8.46hr a: 263. Whatis therate of constant of the drug having half-life of 7days? a 0.25 day” b. 1.23 day" c. 0.10 day” a 0.099 day 264, How long will it take to decompose radioactive Mobidium to 10% from its initial concentration (100%)? (K =0.25 x 107 years) a 921.2 years, b. 1001.3 years c 585.6 years 4. 285.1 years 100Reference guide for Pharmaceutical calculations Second Edition 265. If the probability of success in Null Hypothesis is 0.3, what would be the prob- ability of failure? a0. b 05 ce 07 4 O01 266, Whatis the rate of constant after 100 days if the initial concentration of a dug is 5000 megi/ce, and 50 megice after 100 days? a 0.21 day" b.- 131day" c 211day a 0.046 day" 267. Whatis the apparent volume of distri- bution of 0.375 mg Lanoxinif the plasma con- centration of the drug is 1.2 ng/tnl? a 312L b. 101L e :252L a 5L 268. What is the pH of a solution having a hydrogen ion concentration 10° moles/L? a3 bie fGaaeeea| a8 269. If 1 gm of Cefazolin is reconstituted with 10 ce of SWFI, and the resultant solu- tion is inserted into 100 cc 0.9% sodium chlo- ride. If this solution requires over 12 hour pe- riod to infuse, what would be the flow rate of infusion in drops/min%(LV. set delivers 20 drops per cc) 2. bees. ‘wow.pharmacyexam.com Krisman CG ganic: 270. If 10 ce of 50% KCI injection is di- luted up to 500 ce mark with plain water, what would be the concentration of KCl in meq/5 cc? (mw = 74.5 gm/mole) a 12meq b. 0.51 meq ce. -3.21meq 4 0.671 meq 271. Ifa prescription calls to dispense 1 pint of Li,CO, solution in such a way that I tea- spoonful of solution contains 5 meq of drug, how many grams of Li,CO, are required to prepare above prescription? (mw = 74 gv’ mole) a 17.76 gm b. 15.60 gm ce. 48.11 gm a 60.11 gm 272. How many calories are provided by 250 cc D,,W solution? a. 10 calories b. 35 calories c. 85 calories d. 45 calories 273. What is the volume of Dextrose solu- tion required to prepare a peripheral parenteral solution for Mr. Mehta that provides 1400 nonprotein calories and 45 gm of amino acid. The formulation should provide 35% of non- protein calories as fat and have a maximum dextrose concentration of 15%. a. 1800.11 ce . —-1423,23 ec ec. 1351.1ec d 1784.31 cc 101Reference guide for Pharmaceutical calculations Second Edition 274. What would be the total calories pro- vided by TPN mixture containing 1000 cc of 10% amino acid, 500 ce of 10% emulsion? a. 1000 calories b. 1200 calories c. 1320calories 950 calories 275. If 10 tablets of sodium bicarbonate each weighting 650 mg are crushed and added to 1000 cc water, what would be the concen- tration of drug in meq/ml? (MW = 84 gm/ mole] a. 0.12 meg/ml b. 0.030 meq/mt cc. 0.50meq/ml 4. 0.077 meq/ml 276. How many ce of 2% KMnO, solution are required to prepare 10 pints of 1 in 500 solution? a Tpint b. 1 gallon ce. 1 quart dL teaspoon full 277, The ratio of ionized to unionized ace- tic acid is 1. What is the PH of the solution? [PKa= 5.5] a 35 b 55 we 25 a 65 278. Whatis the volume of 10% amino acid solution are required to prepare a peripheral nutrition in such a way that 55% of calories, are provided by dextrose and the rest by the amino acids. The formulation should provide a total of 1400 calories. www.pharmacyexam.com Krisman a IIlee b. 1575.c¢ ce. 1800 ce a 1213¢e 279. How much Timolol is required to dis- pense 15 ce 0.05% opthalamic solution? a 715mg b. 15mg c 32mg da 89mg 280. If the probability of failure in a Null hypothesis is 0.2, what would be the probabil- ity of success? a 08 b. . 07 ce 12 a 24 281. Whatis the half-life of the drug in first order kinetic if 50 mg/cc of drug remain in a solution after 60 minutes? (Initial concentra- tion of drug was 500 mg/cc) a 18.23 minutes b. 5.15 days c 0.038 minutes” da 12.11 months 282. The recommended therapeutic dose of ‘Theophylline is 20 meg/kg/day. How many 500 meg/50 ce ready-infusion bags are re~ quired to fill 7 day supply? (patient weight is 110 tbs). rd UAW a 14 bd Go ABN te a) 283. How many milligrams of KMnO, is present in 1000 ¢c 0.02% KMn0, solution? 102Reference guide for Pharmaceutical calculations Second Edition a. 02mg b 0.02 mg ©. 2000 mg a 200mg 284. If 10 cc of 0.1 N NaHCO3 solution is, diluted with water up to 100 cc mask, and 20 cof the resultant solution is diluted with water up to 50.ce mark, what would be the final con- centration of drag in meg/ml? (mw = 84 gm/ mole) 10 mog/ee 336 meg/ee 421 meglce 18 meg/ee nose 285. How many grams of drug are required to prepare 500 ce 0.25 N solution? (equiva- lent weight of drug = 356 gm/mole) a. 2B.gm b. 101.2. gm ce. 31.23 gm ad 445 gm 286. How many calories are provided by 1 pint 1 in 50 solution of dextrose? a, 15.11 calories b. 101.23 calories c. 32.64 calories d. 25.16 calories 287. If 100 tablets of Synthroid 0.25 meg are crushed and diluted with water up to 50 cc, what is the % of the drug in the final solu- a. 0.025% wiv b. 0,0025% wiv .0,00005% wiv 4 0.0125% wiv woww.pharmacyexam.com Krisman 288. How many capsules of 150 mg Clin- damycin are required to prepare 100 cc of 2% Clindamycin solution? a 11 b. 8 «21 a 14 289, Whatiis the weight in grams of 120ce of drug having a specific gravity of 2.2 gm/ co? a 132gm b. 264. gm c. 311 gm 4 98.gm 290. How many meq of Ca" are present in 500 mg of CaCO,? (mw of CaCO, = 100 gm/ mole) a 15meq b. 25 meq ec. — 10meq d 5meq 291. How many milligrams of drug are re- quired to prepare 250 cc, 1 in 750 solution? a 521mg db. 102mg. c 251mg 4 333mg 292. Ifanadult dose of drugis 250 mg, what would be the dose for a child having a body surface area of 40 mm?? a 102.3mg b. 57.8mg c. 15.11 mg a 31.12mg 103Reference guide for Pharmaceutical calculations Second Edition 293. Ifanadult dose of drugis 500mg, what ‘would be the dose for a child having a weight of 42 Ibs? a 210mg b. 325mg ce. 460mg a4 140mg 294. anadult dose of drug is 250 mg, what would be the dose for a 3 months old infant? a 7mg b. 125mg c Sm . a 10mg 298, How many calories are provided by 300 ce 1 in 50 fat emulsion? a. 110 calories b. — S4calories ce. — 70calories 4. 91 calories 296. 50 cc 3% glycerol provides: a. 6.45 calories b. © 15.11 calories c. 9.98 calories a 4.1L calories 297. 12 ounces of Kingfisher beer (5% al- cohol v/v) provides: a 100.8 calories, D. + 20.25 calories c. 18.11 calories d 32.11 calories 298. How long will it take to administer 5000 cc of TPN solution with arate of 50 cc! g/day in a patient weighing 150 Ibs? www.pharmacyexam.com Krisman a 14. hours b. 60.2hours ce. &1Lhours d 35.2hours 299. How many calories are provided by 500 ce 3% amino acid solution? a. 23 calories b. 15 calories ce. 40 calories a. 60calories 300. How many cc of 10% amino acid so- ution are required to provide Lgm/kg/day in a patient weighing 150 Ibs? 125.11 cc 253.14 ce 681.81 cc 421.11 ce. aege “Lhuimaseeeneee END iret ene EreReference guide for Pharmaceutical calculations Krisman Second Edition ANSWERS FOR PRACTICE TEST 1B 3. B 8. BH 127. D 2a: 44.°~«C 8. B 128, A 3 OB 45. OC 387. 12% A 4 04 46. 88. 130. B 5 OC 47. D 89. D 131. C 6 D 48. D 90. A 132. D ee 4. 8 1B 133. C 8% oD 50. A 92. € 134, B 9% CC 51 93 «A 135. C 10. =D 52 C 94, ~B 136. A wooA 33. iD 95. C 137. A 2 C 54. A 96. =D 138. A BOA 55. D 97, A 139. B 4 C 56. A 98. A 140. D B.C 37. D 9 OB 141. D 16. C 58. =D 100. C 14. 3B 7 A 39. OC 101. A 14. B 18. C 0. OB 102. B 144. 2B 1%. &B oA 103. A 145. C 20. 62 A 104, A 146. D 2. 0A 6. B 105. A 147. A 2 C 4. OB 106. C 148. B 2B. A 6 A 107. D 149. A 0 A 6. &B 108. A 150. B 28. on. 109. A 151. C 26. C 6. oC 10.. C 152 C 2 A 6. D mu. Cc 153. C 28. B 7m. A 12. ~D 154. 2 A mn A 13. B 155. -D 30. A R B m4 A 156. C 31. OB B. B 115. B 157. 32. OD “4. OB 16. B 158. C 3. B BB 7 C 159. D 34. C 6. D us. C 160. C 35. D 7. © 119. D 161. 36. A 78. A 120. D 162. 37. 9. B 121. D 163, B 38. A 80. 122. D 164. A 39. C 81. D 123, A 165. A 40. B 820A 124, B 166. A 4. OB 3. A 25. C 167. A 42. &B 34 OA 126. € 168, A wwww.pharmacyexam.com 105Reference guide for Pharmaceutical calculations Second Edition 169. A 23. D 257. 170. B A 258. 1m. B D 259, 172 C c 260. 173. C A 261. 14. D B 262. 175. D A 263. 176. B A 264, a7. A B 265. 178. B 266. 179. B D 267. 180. B A 268. 181. C cA 269. 182, D D 270. 183. B B 2. 184. A A 22. 185. B 273. 186. B A 274, 187, B D 275. 188. B A 276. 189. A 277. 190. D D 278. 191, A A 279: 192 B c 280. 193. B 237. 281. 194. 238. D 282. 195. 239. A 283, 196. D 240. D 284. 197. B 21 B 285. 198. A 22. D 286. 199 A 243. A 287. 200. A 244. OB 288. 201. 245. B 289. 202. ~D 246. A 290. 203. A 247. D 291. 204. A 248. A 292, 205. B m9, A 293. 206. D 250. iD 294. 207. A 251 A 295. 208. A 252. D 296. 209. 253, C 297. 210. 254. -D 298. 2U. A 255. D 299. 22. B 256. D 300. wwwpharmacyexam.com CUO RR WOO RU OR OOOO MOP RR PEEP OOOOP OEP OAR Or EATON Krisman 106