Oxycodone/Acetaminophen (Percocet, Endocet, Magnacet, Primalev, Roxicet, Roxilox, Tylox)

Classification: Opioid agonists, opioid agonists/nonopioid analgesic combinations

Schedule II drug/ Controlled substance must be locked up and counted before dispensing
Indication: Management of moderate to severe pain (give patients pain info)
Contraindications: (Do not give) If hypersensitivity to oxycodone/acetaminophen, Severe Hepatic/Renal disease,
OB, Lactation Use Cautiously: Head trauma, increased intracranial pressure, severe renal, hepatic pulmonary disease
Dosage Range: Oxycodone: PO Adults more than or equal to 50kg) 5-10 mg q 3-4 hr prn | PO Adults less than 50kg
or Children 6-12yr 1.25mg q6hr prn or 0.2mg/kg q3-4hr prn| PO children >12: 2.5mg q6hr prn | Rectally(Adults):
10-40mg 3-4 times daily prn
Available as: (Know which dose you are giving according to MD order)
Percocet 2.5/325 Percocet 5/325 Percocet 7.5/325 Percocet 7.5/500 Percocet 10/325 Percocet 10/650
Major Side Effects: Oxycodone: CNS: confusion, sedation, dizziness, dysphoria, euphoria, floating feeling,
hallucinations, headache, unusual dreams EENT: blurred vision, diplopia, miosis Respiratory Depression CV:
orthostatic hypotension GI: constipation, dry mouth, nausea, vomiting GU: urinary retention Skin: flushing,
sweating Misc: Physical/psychological dependence, tolerance
APAP Side Effects: Hepatic failure, Hepatotoxicity, renal failure (high doses) (4 G/ Day)

Nursing Implications: (Information Specific to your Patient) Always check for allergies
Assessment: assess type, location, and intensity of pain prior to and 1hr after administration.
ASESS: BP/ Pulse/ and Respirations before and periodically during admin.
Hold If respiratory rate is <10/min assess level of sedation ; Physical stimulation may be sufficient to prevent
significant hypoventilation. Assess bowel function routinely. Prevention of constipation should be instituted with
increased intake of fluids and bulk, and laxatives to minimize constipating effects. Stimulant laxatives should be
administered routinely if opioid use exceeds 2-3 days, unless contraindicated

LAB test: may increase plasma amylase and lipase levels.

Oxycodone/Aspirin (Percodan, Endodan)
Classification: Opioid agonists/ nonopioid analgesic combination
Schedule II drug/ Controlled substance ( must be locked up and counted before dispensing)
Indication: Management of moderate to severe pain (give pt pain info)
Contraindications: (Do not give) If hypersensitivity to oxycodone/aspirin, tartrazine, or other salicylates. Bleeding
disorders or thrombocytopenia. Children or adolescents w/ viral infections (reye’s syndrome) Severe Hepatic/Renal
disease, OB, Lactation Use Cautiously: Head trauma, increased intracranial pressure, severe renal, hepatic
pulmonary disease
Dosage Range: Oxycodone: PO Adults more than or equal to 50kg) 5-10 mg q 3-4 hr prn / PO Adults less than
50kg or Children 6-12yr 1.25mg q6hr prn or 0.2mg/kg q3-4hr prn / PO children >12: 2.5mg q6hr prn
Rectally(Adults): 10-40mg 3-4 times daily prn / Aspirin: do not exceed 4g/day
Available As: (know which dose you are giving according to MD order) 4.88mg oxycodone + 325mg
Major Side Effects: Oxycodone: CNS: confusion, sedation, dizziness, dysphoria, euphoria, floating feeling,
hallucinations, headache, unusual dreams EENT: blurred vision, diplopia, miosis Respiratory Depression CV:
orthostatic hypotension GI: constipation, dry mouth, nausea, vomiting GU: urinary retention Skin: flushing,
sweating Misc: Physical/psychological dependence, tolerance
Aspirin: GI: GI bleeding dyspepsia, epigastric distresss, nausea, abdominal pain, anorexia hepatotoxicity, vomiting
Exfoliative dermatitis, stevens-johnson syndrome, toxic epidermal necrolysis, anemia, hemolysis, increased
bleeding time
Nursing Implications: (Information Specific to your Patient) Always check for allergies.
Assessment: assess type, location, and intensity of pain prior to and 1hr after administration.
ASESS: BP/ Pulse/ and Respirations before and periodically during admin.
Hold If respiratory rate is <10/min assess level of sedation ; Physical stimulation may be sufficient to prevent
significant hypoventilation. Assess bowel function routinely. Prevention of constipation should be instituted with
increased intake of fluids and bulk, and laxatives to minimize constipating effects. Stimulant laxatives should be
administered routinely if opioid use exceeds 2-3 days, unless contraindicated
LAB test: may increase plasma amylase and lipase levels.
Omeprezole (Prilosec, Prilosec OTC) Classification: proton-pump inhibitors
Indication: GERD/maintenance of healing in erosive esophagitis. Duodenal ulcers (w/ or w/o anti-infectives for
Helicobacter pylori) Short term treatment of active benign gastric ulcer. Pathologic hypersecretory
conditions(Zollinger-Ellison syndrome) Reduction of risk of GI bleeding in critically ill pts. OTC: Heartburn
occurring more or equal to twice/week.
Dosage Range: PO(Adults): GERD/erosive esophagitis 20mg once daily. Duodenal ulcers ass. w/ H. Pylori 40mg
once daily in the morning w/ clarithromycin for 2wk then 20mg daily for 2wk or 20 mg twice daily w/
clarithromycin 500mg twice daily and amoxicillin 1000mg twice daily for 10 days(if ulcer present at beginning of
therapy, continue omeprazole 20 mg daily for 18 more days) gastric ulcer 40mg 1x/day for 4-6 wk.
PO (Children 1-16yr and 5-9kg) GERD 5mg daily PO (Children 1-16yr and 10-19kg): GERD 10mg 1x/day
PO (Children 1-16yr and equal to or more than 20kg) 20mg/day
Major Side Effects: CNS: dizziness, drowsiness, fatigue, headache, weakness CV: chest pain GI: abdominal pain,
acid regurgitation, constipation, diarrhea, flatulence, nausea, vomiting Skin: itching, rash Misc: allergic reactions.
Nursing Implications: Assess pt. routinely for epigastric or abdominal pain and frank or accult blood in the stool,
emesis, or gastric aspirate LAB Test: Monitor CBC w/ differential periodically during therapy, may increase AST,
ALT, alkaline phosphatase and bilrubin, may cause serum gastrin concentrations to increase first 1-2wk of therapy.
Monitor INR and prothrombin time in pt’s taking warfarin.
Give before meals preferable in the morning. Do not crush/chew capsule. Capsules may be sprinkled on cool
applesauce (ingest immediately & drink water) (do not store for future use)

Mylanta II, DS- Magnesium Hydroxide/aluminum hydroxide (Alamag, Gaviscon, Simethicone, Maalox, Mylanta
DS)
Classification: Antiacids
Indication: useful in a variety of GI complaints, including Hyperacidity, Indigestion, GERD, Heartburn,
excess gas (simethicone) (helps belching/ passing flatus)
Contraindications: (Do not give) severe abdominal pain of unknown cause, especially if accompanied by
fever; renal failure, (CrCl <30 ml/min)
Dosage Range: Magnesium/Aluminum Hydroxide: PO Adults & Children >12 yr 5-10ml or 1-2 tabs 1-3 hr
after meals and at bedtime.
Major Side Effects: GI: Constipation, diarrhea, hypermagnesemia, hypophosphatemia
Nursing Implications: Assess for heartburn and indigestion as well as location, duration, character, and
precipitating factors of gastric pain
LAB Test Considerations: Monitor Serum phosphate, potassium, and calcium levels periodically during
chronic use. May cause increased serum calcium and decreased serum phosphate concentrations