PATHOPHYSIOLOGY

Predisposing factor:

Vascularinsufficiency
disorders
Genitor urinary infection
Respiratory infection
IV drugs
Immunocompromisnig
diseases

Open wounds/fracture

Microorganism gain
entry by way of blood

Microorganisms lodge into an area

where circulation slows

Microorganism grows

Increase pressure
 Ischemi Vascular compromise
a of the periosteum
Fever, night
sweats, chills,
restlessness,
N/v, constant
Infection through the bone pain,
bone cortex and swelling,
marrow tenderness,
warmth at the
infection site,
restricted
movement of
Cortical
the affected
devascularization
part

Debrideme Necrosis
nt

Formation of new bone Separation of involcrum

devitalized bone from
living bone
involcrum
Continous to be an
infected island
 Difficulty to reach by
blood borne antibiotics

Chronic
Enlarged sequestrum

Drainage Development of sinus Sequestrum move out

from sinus tract of the tissue
tract
Turns to scar tissue
revascularized
Excessive vascular
Systemic Site for continued insuficiency
signs may be microorganism growth Removal by the normal
diminished immune process
Loss of organ function
with constant
pain, Remission and
swelling, exacerbation
Amputation Healing
tenderness,
warmth at
the infection
site