Name of the Adverse

Action Indications Dosages Contraindications

Drug Reactions
Generic Name: Inhibits carbonic  Adjunctive treatment Take with food. Hypersensitivity to CNS: drowsiness,
Acetazolamide anhydrase activity. As of chronic simple Do not crush sulfonamides, anxiety,
an anticonvulsant, (open angle) sustained-release severe renal or depression,
Brand Name: inhibition of carbonic glaucoma and capsules. hepatic disease, headache,
(Philippines) anhydrase in the CNS secondary glaucoma. Glaucoma: electrolyte dizziness,
Diamox increases carbon dioxide  Preoperative 250mg to 1g/day imbalances confusion,
tension resulting to treatment of acute in divided doses. (hyponatremia, stimulation,
decrease neuronal congestive (closed- Epilepsy: 8-30 hypokalemia), fatigue, seizure,
conduction. As a angle) glaucoma. mg/kg BW in hyperchloremic sedation,
diuretic, inhibition of  Prevention or divided doses. acidosis, Addison’s nervousness
carbonic anhydrase in lessening of Range: 375mg to disease, long term Endocrine:
the kidney decreases symptoms associated 1 g daily. use in narrow-angle hyperglycemia,
formation of bicarbonate with acute mountain CHF: 250-375 glaucoma. hypokalemia,
and hydrogen ions for sickness. mg once a day. hypocalcemia,
active transport.  Adjunctive treatment Drug-induced hypomagnesia,
Inhibition of carbonic of (1) edema caused edema: 250-375 hyponatremia,
anhydrase in the eye by CHF or drug- mg once a day for hyperchloremia
decreases aqueous induced edema and 1-2 days. EENT: myopia,
humor which lowers (2) centrencephalic tinnitus,
intraocular pressure. epilepsies (e.g. petit photosensitivity
mal, generalized Skin: paresthesia,
seizures) purpura, rash,
pruritis, urticaria
GI: nausea,
vomiting,
anorexia,
constipation,
diarrhea, melena,
weight loss,
hepatic
insufficiency, taste
 alterations
GU: polyuria,
uremia,
glucosuria,
hematuria,
dysuria,
crystalluria, renal
calculi
Hematologic:
Aplastic anemia,
hemolytic anemia,
leucopenia,
agranulocytosis,
thrombocytopenia,
pancytopenia
Other: fever,
Stevens-Johnson
syndrome

Name of the Adverse

Action Indications Dosages Contraindications
Drug Reactions
Generic Name: Binds to bacterial  Treatment of Adults, Hypersensitivity to CNS: loss of
Amikacin ribosomal subunit to cause infections caused by Children, and amikacin. History balance
misreading of the genetic susceptible strains of Infants: IV/IM of hypersensitivity EENT: hearing
Brand Name: code which leads to microorganisms, 15mg/kg(ideal or serious toxic loss, deafness
(Philippines) inaccurate peptide especially gram- body weight)/day reactions to GU: oliguria,
Amikacide, sequence of protein negative bacteria. in 2 or 3 divided aminoglycosides. proteinuria,
Amikin, synthesis and bacteria doses. Treatment increase serum
Cidacid, death. in heavier patients creatinine, urinary
Kormakin, Nica should not exceed casts, red and
Route Onset Peak 1.5g/day white blood cells
15-30 Uncomplicated in urine,
IM Rapid UTIs: IV/IM 250 azotemia,
mins
 1-2 mg BID. decreased serum
IV Rapid
hrs Newborns: magnesium
IV/IM Loading
dose of 10 mg/kg
is recommended
followed by 7.5
mg/kg every
12hrs. Lower
doses may be
needed in first 2
weeks of life.

Name of the Contraindicatio Adverse

Action Indications Dosages
Drug ns Reactions
Generic Name: Aminophylline is a combination  Management of Bronchospasm: Hypersensitivity CNS:
Aminophylline of theophylline and bronchospasm Adult: IV to xanthine Nervousness,
ethylenediamine.  Relieve apnea in Loading Dose 6 derivatives or to restlessness,
Brand Name: Ethylenediamine is inactive; it neonates mg/kg over 30 ethylenediamine depression,
Corophyllin , increases the solubility of min. IV component; insomnia,
Paladron , theophylline in water. Maintenance Dose cardiac irritability,
Phyllocontin, Theophylline relaxes bronchial nonsmoker, 0.5 arrhythmias. headache,
Somophyllin, smooth muscle. Suggested mg/kg/h; dizziness, muscle
Somophyllin- mechanisms are an increase in smoker, 0.75 . hyperactivity,
DF, Truphylline intracellular cAMP through mg/kg/h; CHF convulsions.
inhibition of phosphodiesterase; or cirrhosis, CV: Cardiac
adenosine receptor antagonism, 0.25 arrhythmias,
prostaglandin antagonism and mg/kg/h. PO tachycardia (with
effects on intracellular calcium. nonsmoker, 0.5 rapid IV),
mg/kg/h times hyperventilation,
24 h in 4 divided chest pain, severe
doses; smoker, hypotension,
0.75 mg/kg/h cardiac arrest.
times 24 h in 4 GI: Nausea,
divided doses; vomiting,
CHF or anorexia,
cirrhosis, 0.25 hematemesis,
mg/kg/h times diarrhea,
24 h in 4 divided epigastric pain.
doses
Child: IV
Loading Dose 6
mg/kg IV over
30 min. IV
Maintenance Dose
1–9 y, 1
mg/kg/h; >9 y,
0.75
mg/kg/h. PO 1–9
y, 1 mg/kg/h
times 24 h in 4
divided doses;
>9 y, 0.75
mg/kg/h times
24 h in 4 divided
doses
Infant: PO/IV 6–
11 mo, 0.87
g/kg/h; 2–6 mo,
0.5 mg/kg/h
Neonate: PO/IV
0.16 mg/kg/h
Neonatal
Apnea: PO/IV
Loading Dose:5
mg/kg. PO /IV
Maintenance Dose
 5 mg/kg/d
divided q12h

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Binds to sterol in the fungal  Treatment of Amphotericin B Hypersensitivity, CNS: headache
Name: cell membrane causing progressive, potentially desoxycholate: severe bone GI: anorexia,
Amphotericin alteration in membrane fatal infections caused Adults: IV test dose marrow weight loss,
B permeability, leading to by certain fungal of 0.05 mg/ml depression. nausea,
leakage of intracellular species. infused slowly over vomiting
Brand Name: components.  Amphotericin B 20 to 30 mins. dyspepsia,
(Philippines) desoxycholate: Systemic Fungal diarrhe
Fungizone Route Onset Peak Treatment of Maerican Infections: Adults: Other: fever,
Immedi 1-2 mucocutaneous IV initial malaise
IV recommended dose
ate hrs leishmaniasis.
 Amphotericin lipid- 0.25 to 0.3
based: treatment of mg/kg/day infused
invasive fungal slowly over 2 to 6
infections in patients hrs. Dose increased
refractory to gradually up to 0.5
conventional to 0.7 mg/kg/day
amphotericin B and up to 1.5
desoxylate or when mg/kg/day for
renal impairment or some mycoses
unacceptable toxicity (maximum daily
precludes use of the dose 1.5
desoxycholate mg/kg/day). Daily
formulation (lipoid dose varies with
complex) type of infection,
 Treatment of infections ranging from 0.5 to
caused by Aspergillus, 1.5 mg/kg/day for 4
Candida, or to 12 wks.
Cryptococcus species However,
 (liposomal) aspergillosis
 Empirical treatment of regimen is 1 to 1.5
febrile, neutropenic mg/kg/day up to a
patients with presumed total treatment dose
fungal infections of 3.6 g
 Treatment of visceral Rhinocerebral
leishmaniasis. phycomysis
 Amphotericin B regimen: 0.25 to
cholestryl: treatment of 1.5 mg/kg/day to a
invasive aspergillosis. total treatment dose
 Amphotericin B of 3 to 4 g.
(topical): treatment of Sporotrichosis
cutaneous mycotic regimen: 0.5
infections caused by mg/kg/day up to a
Candida sp. total treatment dose
of 2.5g.

Contraindicati
Name of the Drug Action Indications Dosages Adverse Reactions
ons
Generic Name: Interferes with cell wall  Treatment of Administer 1 hr Hypersensitivit CNS: dizziness,
Ampicillin synthesis of susceptible respiratory before or 2 hrs y to penicillins, neurotoxicity,
(Ampicillin organisms, preventing tract and soft after a meal. cephalosporins Endocrine:
Trihydrate) bacterial multiplication, it tissue Adults: or imipenem. EENT: itchy eyes,
also renders the cell wall infections, Orally/IV/IM 50 Oral form not laryngospasms,
Brand Name: osmotically unstable and bacterial to 200 used to treat laryngeal edema
(Philippines) burst due to osmotic meningitis, mg/kg/day in severe Skin: urticaria,
Ampicin, pressure. Deactivated by septicemia and divided doses pneumonia, maculopapular to
Amplivacil, beta-lactamase, an enzyme gonoccocal every 4 to 6 emphysema, exfoliative dermatitis,
Bactimed, by resistant bacteria. infections hours. bacteremia, vesicular eruptions,
Celidam, DLI caused by Infants >7 days pericarditis and erythema multiforme,
Ampicillin, Route Onset Peak susceptible and >2000g: purulent or skin rashes
Drugmaker’s PO Rapid 2 hrs microorganism IV/IM septic arthritis GI: diarrhea,
Biotech IM Rapid 1 hr s. 100mg/kg/day in during acute pseudomembranous
Ampicillin, Infusi  Prophylaxis in divided doses stage. colitis
Eurocin, IV Rapid every 6 hrs. GU: interstitial
ons rape victims
Genaxcin, and for Infants >7 days nephritis, nephropathy,
Panacta, bacterial and <2000g: increased BUN and
Penbritin, endocarditis. IV/IM 75 creatinine, vaginitis,
Pentrexyl, mg/kg/day in Hematologic:
Picaplin, Saloxin, divided doses thrombophlebitis at
Shinapen, Vatacil every 8 hrs. injection site, dcreased
Infants <7 days Hgb, Hct, RBC, WBC,
and >2000g: neutrophils, eosinophils
IV/IM 7 and platelets elevated
mg/kg/day in serum alkaline
divided doses phosphatase, glutamic
every 8 hours. oxaloacetic
Infants <7 days transaminase, ALT,
and <2000g: AST, and LDH,
IV/IM 50 reduced serum
mg/kg/day in albumin, and total
divided doses proteins
every 12 hrs. Other: fatigue,
insomnia, reversible
hyperactivity, pain at
injection site,
hyperthermia

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Name: Interferes with cell wall  Treatment of Give on an empty History of CNS:
Cloxacillin replication of susceptible infections caused by stomach atleast 1 hr hypersensitivity to Endocrine:
organisms, the cell wall, pneumococci, Group before or 2 hrs after penicillins and EENT:
Brand Name: rendered osmotically A beta-hemolytic meals unless cephallosporins. occasionally,
(Philippines) unstable, swell, bursts from streptococci, and otherwise advised Sever pneumonia, laryngeal edema,
Avastoph, osmotic pressure; resists penicillin G sensitive by physician. emphysema, Skin: urticaria,
Cibacter, the penicillinase action that staphylococci. Mild to moderate bacteremia, skin rashes,
Drugmaker’s inactivates penicillins.  Sinusitis, skin and soft upper respiratory pericarditis, exfoliative
Biotech tissue infections, and localized skin meningitis and dermatitis, rash
Cloxacillin, Route Onset Peak bones and joint and soft tissue purulent and GI: GI
Encloxil, PO ½ hr 1/2 infections, respiratory infections: Adult septic arthritis disturbances,
Lewinex, Medix, and urinary tract and Pedia more during the acute nausea, vomiting,
Myrex infections, than 12 y/o: 250 the stage. Sub- epigastric distress,
Cloxacillin, genitourinary mg every 6 hrs. conjunctival diarrhea and
Orbenin, infections, ear, nose Pedia less than 20 infections. flatulence,
Oxaclen, and throat infections. kg: 50 mg/kg/day in antibiotic-
Pannox,  Otitis media, equally divided associated
Patriflex, Pharex endocarditis, doses every 6 hours pseudomembrano
Cloxacillin, septicemia, meningitis or as prescribed. us colitis
Prostaphlin-A,  Prophylaxis: Severe infections: GU: interstitial
Ritemed Staphylococcal Adult and Pedia nephritis and
Cloxacillin, infection during major more than 12 y/o: vasculitis
Secloxin cardiovascular and 50Omg-1g every 6 Hematologic:
orthopedic surgery. hrs. eosinophilia,
Pedia less than 20 agranulocytosis,
kg: 100 mg/kg/day anemia,
or more in equally thrombocytopenia,
divided doses every transient rise in
6 hours or as transminases and
prescribed. alkaline
Vial: Usual dose phophatase
250mg by IM every Other:
4 to 6 hrs or 500mg hypersensitivity
may be given by reactions, serum
slow IV inj over 3 sickness-like
to 4 mins every 4 to reactions, fever,
6 hrs or by IV
infusion.
 Children aged 2 to
10 yrs: ½ the adult
dose.
Children up to
2y/o:1/4 the adult
dose or as
prescribed.

Name of the Adverse

Action Indications Dosages Contraindications
Drug Reactions
Generic Inhibits bacterial cell wall synthesis,  Infections Adult IM or IV: Allergy to Skin: skin
Name: thus promoting osmotic instability caused by 500mg to 1g very 8 penicillins and rash
Cefazolin which eventually leads to bacterial staphylococcus, to 12 hrs. usual cephalosporins. GI: nausea,
cell death. streptococcus, maximum daily dose: vomiting,
Brand Name: E.Coli, D. 6 g, up to 126 in anorexia,
(Philippines) Rout Onse Peak Duratio pneumonia, severe life- diarrhea, oral
Fonvicol, e t n Proteus spp. threatening thrush
Ilozef, Lupex, Rapi 6-12 And other infections. Hematologic:
Stancef IM 1-2 hrs Children over 1 eosinophilia,
d hrs susceptible
10 Infusion microorganisms. month: 25-50 mg/kg leucopenia,
IV
mins s end Respiratory tract BW daily in 3 or 4 reversible
infections, divided doses, thrombopenia
genitourinary increased in severe , transient rise
tract infections, infections to a in SGOT,
gynecological maximum of 100 SGPT and
infections, skin mg/kg daily. alkaline
and skin Surgical phosphates
structure Prophylaxis: 1g 3o Other:
infections, pre- minto 1 hr before the allergy, fever,
and post- operation, followed shock, Vit B
operative wound by 500 mg to 1g group
 and trauma, during surgery for deficiencies
biliary tract lengthy procedure. A
infections bone dose of 0.5 to 1g is
and joint given every 6-8 hrs
infections, post-operative for 24
perioperative hrs or up to 5 days in
prophylaxis. certain cases.
 Treatment of For patients with
septicemia and renal impairment:
endocarditis. initial dose of 500mg
through IV route –
severe and very
severe infections
Creatinine clearance
50-20mL/min:
500mg every 12 hrs;
20-10mL/min:
500mg every 24hrs;
10-5 mL/min: 500mg
every 48-72 hrs; less
than 5mL/min in
patients undergoing
hemodialysis: 500mg
every 72 hrs. Less
severe infections
Creatinine clearance
50-20mL/min:120-
250mg every 12 hrs;
20-10mL/min:120-
250 mg every 24 hrs;
10-15 mL/min: 75-
125 mf every 24 hrs;
less than 5 mL/min in
 patients undergoing
dialysis: 50-75mg
every 72hrs.

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Inhibits bacterial cell wall synthesis,  RTI, UTI, Adult 1:1 Allergy to CNS:
Name: rendering cell wall osmotically peritonitis, ratio: 2-4g or penicillins headache
Cefoperazone unstable, leading to cell death. cholesystitis, 1:2 ratio: 1.5- sulbactam or CV:
cholangitis, and 3g. Administer cephalosporins. hypotension
Brand Name: Route Onset Peak Duratio other 12 hrly in Skin:
(Philippines) n intraabdominal equally mucopapular
Bactizon, unkno unknow infections. divided doses. rash, urticaria,
Endure IM 1-2 hrs Severe or pruritus
wn n  Septicemia,
Medical immedi immedia unknow menigitits, skin refractory GI: diarrhea,
Cefoperazone IV infections: nausea,
ate te n and soft tissue
infections, bone dose may be vomiting,
and joint increased up to pseudomembra
infections 8 g of the 1:1 nous colitis
 PID, ratio or 12g of GU:
endometriosis, the 1:2 ratio. hematuria,
gonorrhea, and Patients vasculitis
other genital tract receiving the Hematologic:
infections. 1:1 ratio may leucopenia
require Other:
additional Anaphylacoida
cefoperazone l reactions,
administered Steven Johnson
separately. syndrome
Pedia 1:1
ratio: 40-80
mg/kg/day or
1:2 ratio: 30-
 60 mg/kg/day.
Doses should
be
administered
6-12 hrly in
equally
divided doses.
In serious or
refractory
infections,
dose may be
increased up to
160 mg/kg/day
of the ratio 1:1
or 240
mg/kg/day of
the 1:2 ratio.
Doses should
be admin in 2-
4 equally
divided doses.
Neonates 1st
week of life:
should be
given 12 hrly

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Inhibits bacterial cell wall synthesis,  Treatment of Unless Hypersensitivity CNS: headache,
Name: rendering cell wall osmotically unstable, infections otherwise to cephalosporins. confusion,
Cefotaxime leading to cell death. caused by stated, dosage Possibility of fatigue
susceptible for asultsand cross-sensitivity GI: anorexia,
Brand Name: Route Onset Peak Duratio microorganis children greater in patients who diarrhea, nausea,
(Philippines) n ms, especially than 12 yrs is have shown vomiting,
Ceptax, unkno unknow serious and 1g every 12 hrs. allergy to abdominal
Cladex, IM 1-2 hrs life- Moderate to penicillin. cramps, colitis
wn n
Claforan, immedi immedia unknow threatening severe Intramuscular Hematologic:
Pantaxin IV infections. infections: 1- administration in transient
ate te n
 Brain abscess, 2g IV every 6-8 conditions with neutropenia,
gonorrhea, hrs impaired granulocytopenia
intensive care, Severe life- hemostasis and , leucopenia,
Lyme disease, threatening severe sepsis. eosinophilia,
meningitis, infections: 2g thrombocytopeni
peritonitis, IV every 4 hrs. a,
pneumonia, Maximum daily agranulocytopeni
septicemia, dose is 12g. a
surgical Prevention of Other:
infection, and post-operative hypersensitivity
typhoid fever. infxns: 1g by reactions
IM or UV 30-90
mins before
surgery.
Cesarean
Surgery: 1g IV
immediately
after the
umbilical cord
is clamped, and
then followed
by 1g IM or IV
6-12 hrs after
the 1st dose.
Gonorrhea: 1g
IM as single
dose.
 Uncomplicated
infxns: 2g or 1g
as single dose
given IM
Patients
undergoing
hemodialysis:
0.5-2 daily
given daily as a
single dose and
additional dose
given after each
dialysis period.

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Inhibits bacterial cell wall synthesis, thus  Peritonitis Administer Allergy to CV: phlebitis,
Name: promoting osmotic instability which and other through IV/IM penicillins and GI: nausea,
Cefoxitin eventually leads to bacterial cell death. intra- Adult usual cephalosporins vomiting
Rout Onset Peak Duratio abdominal dose: 1g or 2g and people with GU: renal
Brand Name: e n and 3x/day. allergic drug impairment
(Philippines) IM Rapid ½ hr <6 hrs intrapelvic Renal backgrounds. Hematologic:
Monowel, immediat immediat unknow infections, insufficiency Other:
Panafox IV gynecological and undergoing allergy,
e e n
, septicemia, hemodialysis:
endocarditis, Loading dose: 1-
UTI, 2g. Maintenance
uncomplicate dose: mild
d gonorrhea, impairment: 1-
respiratory 2g 2x-3x per
tract day. Moderate
infection, impairment: 1-
bone and joint 2g once to twice
 infection, skin a day. Severe
and soft tissue impairment: 0.5-
infections 1g once to 2x per
 Endometritis, day. Essentially
PID, and no function: 0.5-
surgical 1g once a day to
infections every 48hrs.
Uncomplicated
UTI: 1g IM
2x/day
Uncomplicated
gonorrhea:
single dose of 2g
IM given with
1g of probenecid
by mouth at the
same time up to
1 hr before.
Prophylactic
dose: 2g IM/IV
½-1hr before
initial incision
then 2g 4x/day.
CS: administer a
single dose of 2g
IV as soon as the
umbilical cord is
clamped.

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Inhibits bacterial cell wall synthesis, thus  Severe Adult: infections Lactation and CNS:
Name: promoting osmotic instability which infections, e.g. caused by pregnancy. headache,
Ceftazidime eventually leads to bacterial cell death. septicemia, susceptible Hypersensitivity dizziness,
Route Onset Peak Duratio bacterimia, organisms: 1g IV to cephalosporins. tremor,
Brand n RTI, or IM every 8-12 convulsion
Name: unkno unknow complicated hrs. Maximum Skin: skin
(Philippines) IM <1hr and dose: 6g daily. rash,
wn n
Ceftavex, immedi immediat unknow uncomplicated Uncomplicated maculopapula
Fortum, IV UTI, infxns of UTI: 250mg r or urticarial
ate e n
Fortum, ENT, skin and IV/IM every 12 rash, pruritus
Ritemed soft tissues, GI, hrs GI: diarrhea,
Ceftazidime, gynecological Complicated vomiting,
Tazidem, infxns, intra- UTI: 500mg abdominal
Zeptrigen abdominal IV/IM every 8-12 pain, oral
infxns, hrs. thrush, colitis
peritonitis, Uncomplicated GU:
meningitis pneumonia or candidiasis,
infxns mild skin and vaginitis
 Infxns skin structure Hematologic:
associated with infxns: 0.5-1g transient
hemo and IV/IM every 8hrs. hematologic
peritoneal Bone&joint changes
dialysis. infxns: 2g IV Other: fever,
 Prostatic every 12hrs. anaphylaxis
surgery Meningitis: 2g
prophylaxis IV every 8hrs.
Fibrocystic
patients
w/pseudomonal
lung infxns: 100-
150mg/kg/day in
3 divided doses.
Prophylactic
agent in
prostatic
 surgery: 1g at the
induction of
anesthetics. A 2nd
dose should be
considered at the
time of catheter
removal.
Elderly: should
not exceed 3g
daily

Name of the Adverse

Action Indications Dosages Contraindications
Drug Reactions
Generic Name: Inhibits bacterial cell wall  Treatment of Adult usual Hypersensitivity to CNS: headache,
Ceftriaxone synthesis, thus promoting susceptible infxns dose: 1 g/day in cephalosporins and dizziness
osmotic instability which including a single penicillin, Skin: rash,
Brand Name: eventually leads to bacterial chancroid, injection and up lidocaine, or any exanthema,
(Philippines) cell death. gastroenteritis, to 2g/day once other anaesthethic allergic
Forgram, Lyme disease, daily according product of the dermatitis,
Keptrix, Rout Onset Peak meningitis, to the infxn amide type. pruritus, urticaria,
Megion, e syphilis, typhoid severity and the Porphyria, edema, erythema
Pantrixon, IM Rapid 1 hr fever. patient’s bodt unapplied multiforme.
Retrokor, immediat Infusion’  Delayed stage wt. auricular- GI: diarrhea,
Ritemed IV Lyme disease: 2 ventricular block, nausea, vomiting,
e s end with neurological
Deftriaxone, and articular g/day in a single cardiogenic shock. stomatitis,
Rocephin, systemic inj. Usual glossitis
Sergimax, manifestations. therapy is 14 GU: oliguria,
Xtenda  Treatment of days long anc be crytalluria,
LRTI, skin and up to 21 days in increase in serum
soft tissue severe or creatinine,
infections, delayed forms of mycosis of genital
 complicated and disease. tract
uncomplicated Prophylaxis of Hematologic:
UTI, post-operative eosinophiliam
uncomplicated surgical infxns: thrombocytosis,
gonorrhea, PID, 1g in a single leucopenia,
bacterial dose IV/IM inj granulocytopenia,
septicemia, intra- when inducing hemolytic
abdominal infxns, ansthesia, over anemia,
meningitis 24 hrs, not thrombocytopenia
 Pre-operative exceeding 48
prophylaxis to hrs.
reduce chance of Susceptibility
post-operative to Purpura
surgical infxns. fulminans: 1-2g
or as prescribed.
Pedia usual
dose: 50
mg/kg/day in a
single inj.
Lyme disease:
50-100 mg/day
in a single inj
for 14-21 days
Meningitis: 50-
100 mg/kg/day
in a single inj,
100 mg/kg is
only justified as
attack treatment

Name of the Adverse

Action Indications Dosages Contraindications
Drug Reactions
Generic Inhibits mucopeptide synthesis in  Infections Capsule Adult: History of shock to CNS: headache,
Name: bacterial cell wall. caused by RTI and skin this drug, dizziness,
Cefradine Rout Onse Pea Duratio susceptible structure infxns: hypersensitivity to GI: colitis,
e t k n strains of 250 mg every 6 cephalosporinsm stomatitis,
Brand Name: Rapi 6hrs Staphylococci, hrs or 500mg and patients with glossitis,
(Philippines) Oral 1 hr Streptopneumo every 12 hrs. known history of pseudomembrano
d
Altozef, Rapi 1-2 nia, Lobar allergy us colitis
Drugmaker’s IM 6 hrs Haemophilus pneumonia: GU: candidiasis
d hrs
Biotech Influenzae, 500mg every 6 Hematologic:
Cefradine, E.Coli, Proteus hrs eosinophilia,
Sedinef, mirabilis, Uncomplicated leucopenia,
Velodyne, Klebsiella sp., UTI: 500mg neutropenia,
Tolzep, Zedril Streptococci, every 12hrs. Other:
tonsillitis, Skin and skin hypersensitivity
phrayngitis, structure infxns: reactions
lobas 1g/day in single
pneumonia, or divided doses
bronchitis Pharyngitis and
 UTI, protatitis, tonsillitis:
cystitis, 1g/day in single
pyelonephritis, or divided doses
urethritis, for 10 days.
abscess, Pedia over
cellulitis, 9mos. Age usual
impetigo, otitis dose: 25-50
media, GIT mg/kg/day
infxns. administered in
 Bones and joint equally divided
infxns doses every 6 or
 CV infxns 12 hrs
caused by Otitis Media:
Staph. Aureus, 75-100
Streptococci, mg/kg/day in
H. influenza, equally divided
 E.Coli and doses every 6 or
Klebsiella spp. 12 hrs, but
 Prophylaxis of should not
infxns during exceed 4g/day
surgical IM/IV Adults
operations usual dose: 2-4g
 Treatment of daily in 4 divided
post-operative doses. Doses can
infxn including be increased up
vaginal 8 g/day for
hysterectomy, severe or chronic
CS, and infxns
prosthetic Treatment of
arthroplasty. infxns: 500mg
4x a day. Doses
can be increased
for severe or
chronic infxns

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Name: Inhibits protein synthesis in  Typhoid fever, Give preferably History of CNS: headache,
Chloramphenicol bacteria. Acts primarily by meningeal with a full glass of hypersensitivity mild depression,
binding reversibly to the 50s infection, water on an empty and toxic EENT: blurring
Brand Name: ribosomal subunit. bacteremia, stomach, or at reactions. Infants of visions, optic
(Philippines) Rout Onset Peak meningitis or other least 1hr before or <1 month and in neuritis in some
Alphagram, e serious infxns 2 hr after a meal, pregnant women children in
Biomycetin, 15 caused by7 to achieve blood prior to delivery mucoviscodosis
Celsus PO 2-3 hrs
mins susceotible strains levels. due to risk of Skin: paresthesia,
Chloramphenicol Infusion’ of salmonella, Adult: Capsule Gray syndrome. GI: diarrhea,
Eye-Ear Drops, IV rapid 250-500mg or 2 Blood diseases, stomatitis,
s end Rickettsia or
Chloromycetin, Chlamydia, aerobic tsp suspension esp., aplastic glossitis, nausea,
C-Phenicol, DLI- and anaerobic every 6 hrs or as anemia, and vomiting
Chloramphenicol bacteria, cystic prescribed. thrombocytopenia Hematologic:
, Drugmaker’s fibrosis, anti- Pedia: Capsule . Lactation, trivial serious and fatal
Bioatech infective regimens, 125-250mg every infxn. Concurrent blood dyscrasias
Chloramphenicol brain abscess, and 6 hours or as therapy with other Other: allergic
, Medimycetin, other diseases prescribed. bone marrow reactions
Micromycetin, which do not 2-6yrs: ½ tsp; depression, TB
Pediachlor respond to other infants: ¼-1/2 tso affections.
Suspension, standard every 6 hrs daily
Penachlor, antimicrobial preferably after
Pharex agents. feeding time or as
Chloramphenicol prescribed.
, Vamcetin Impaired hepatic
fxn or severe
renal failure:
reduce the dose of
chloramphenicol

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Competitively inhibits histamine H2-  Duodenal and Take with food. Patients with CNS: tiredness,
Name: receptor site of gastritis parietal cells, gastric ulcers, Adult: Active impaired renal dizziness
Cimetidine resulting to decreased gastric acid esophageal ulver and function, Skin: skin
secretion by about 50-80%. reflux, gastroesophage hypersensitivity to rashes
Brand Rout Onset Peak Duratio Zollinger- al reflux Cimetidine. GI: mild
Name: e n Ellison disease: single transient
(Philippines) unknow 45-90 4-5hrs syndrome. bedtime dose of diarrhea
Antag, PO 800mg or Hematologic:
n mins  Prophylaxis:
Biogenerics IM/I unknow immediat unknow GI 400mg twice a decreased white
Cimetidine, V n e n hemorrhage, day in the cell counts,
Drugmaker’s malabsorption morning and at agranulocytosis,
Biotech and fluid loss bedtime. thrombocytopen
Cimetidine, reduction in Duration of ia
Dugastril, patients with therapy: 4 wks Other:
Mestulcer, short bowel for active ulcer, gynecomasia,
Tagamet syndrome, 12 wks for alopecia
systematic gastroesophagea
mastocytosis l reflux
and multiple Gastritis:
endocrine 200mg after
adenomas breakfast and
 Treatment of 200mg at
duodenla and bedtime
benign gastric Prevention of
ulceration. recurrent
 Prevention of ulcer:
stress ulcer maintenance
critically ill dose: 400mg at
patients at risk bedtime
of hemorrhage Zollinger-
 Reduction of Ellison
gastric acidity syndrome:
secretory doses up to
volume. 12g/day have
been used.
NSAID-
induced
lesions: 800mg
at bedtime or
400mg twice a
day for 8 weeks.
Pancreatic
insufficiency:
0.8-1.6 g/day in
4 divided doses,
1-1 ½ hrs before
 meals.

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Name: Synthetic glucocorticoid with marked  Testing adrenal Take with food. Systemic fungal CNS:
Dexamethasone anti –inflammatory effect because of cortical Dexamethason infxns. IM inj use convulsion,
its abilty to inhibit prostaglandin hyperfunction, e: Initial dose: in idiopathic increased ICP
Brand Name: synthesis, inhibit migration of management of given by mouth thrombocytopenia w/
(Philippines) macrophages, leukocytes and primary or 0.75-9 mg/day. purpura, papilledema,
Cordex 5, fibroblasts at site of inflammation, secondary Cushing administration of psychosis,
Decilone, phagocytosis and lysosomal enzyme adrenal cortex syndrome: live virus vertigo,
Drenex, Inflam, release. It can also cause the reversal insufficiency, given by vaccines, topical headache
Isodexam, of increased capillary permeability. rheumatic motuh , 1mg at monotherapy in CV: cardiac
Maxidez, Rout Onset Peak Duration disorders, 11pm. primary bacterial arrhythmias or
Oradexon, e collagen Alternate: infxns ECG changes,
Oradexon 1-2 1-2 2 ½ days diseases, Given by hypertension,
Forte, Santeson PO mouth, 0.5mg myocardial
hrs hrs dermatologic
0.1%, IM/I 2days- diseases, every 6 hrs for rupture, CHF
Scancortin 4, <1 hr 1hr 48 hrs Musculoskelet
V 3wks allergic states,
Scancortin 5 allergic and Acute al: weakness,
inflammatory mountain myopathy,
ophthalmic sickness: given muscle mass
processes, by mouth, 4mg loss,
respiratory every 6 hrs. osteoporosis
diseases, Antiemetic: Skin:
cerebral edema, given by paresthesia,
associated w/ mouth,16-20 petechiae,
primary or mg ecchymoses,
metastatic brain Diagnosis of erythema,
tumor, depression: acneiform
craniotomy or given by mouth, eruptions,
head injury, 1mg. allergic
edematous Dexamethason dermatitis,
states, GI e sodium urticaria,
diseases, phosphate – burining,
multiple systemic: given itching,
sclerosis, TB IV/IM, 0.5- dryness,
meningitis, 9mg/day. pruritus
trichinosis w/ Cerebral GI:
neurologic or edema: IV, pancreatitis,
myocardial 10mg, then IM nauseas,
involvement. 4mg every 6hrs vomiting,
until maximum increased
response. appetite and
Brain tumors: weight gain,
IM/IV,2mg 2- peptic ulcer w/
3x a day perforation and
Unresponsive hemorrhage,
shock: IV, 1- bowel
6mg/kg as perforation
single inj or GU: glycosuria
40mg followed Hematologic:
by repeated IV thrombophlebit
inj every 2-6 is
hrs. Other:
Bacterial
meningitis: IV,
0.15 mg/kg
 every 6 hrs.

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Macrolide antibiotic produced by a  Pneumococcal Give on an Hypersensitivity EENT:
Name: strain of Streptomyces erythreus. pneumonia, empty to erythromycin photosensitivity
Erythromycin Bacteriostatic or bactericidal, Mycoplasma stomach 1hr or any amcrolide Skin: rash,
depending on nature of organism pneumoniae (primary before or 3 antibiotic; pre- erythema and
Brand Name: and drug concentration used. atypical pneumonia), hrs after existing liver peeling
(Philippines) acute PID caused by meals. disease. Epithelial GI: diarrhea,
AM- Rout Onse Peak Duratio Neisseria gonorrhoeae Systemic herpes simplex nausea, vomiting,
Europharma e t n in females sensitive to Use: given keratitis, fungal abdominal pain,
Eryhtromycin, unknow penicillin, infections by mouth, disease of eye, cramping
Celsus PO 1 hr 4hrs caused by susceptible 250-500mg vaccinia or GU: vaginitis
n
Eryhthromyci imm strains of of baseevery varicella. Other: venous
n Eye imme unknow staphylococci, 6 hrs or Lactation, irritationor
IV ediat
Ointment, diate n streptococci, and 500mg Excreted in phlebitis with IV
e
Drugmaker’s certain strains of every 12 hrs breastmilk. administration.
Biotech Haemophilus or 333mg
Erythromycin, influenzae. every 8 hrs.
Elicocin, IV: 15-
Erasymin,  Also used in intestinal 20mg/kg/da
Erosuccin, amebiasis, y; up to
Erycar, Legionnaires' disease, 4g/day in
Eryhthrocin/E uncomplicated very severe
ryhthrocin urethral, endocervical, infxns.
DS, Ery-V, and rectal infections Children:
Ilosone/Iloson caused by Chlamydia given by
e DS, Pharex trachomatis, for mouth, 30-
Erythromycin, prophylaxis of 50
RiteMed ophthalmia mg/kg/day
Erythromycin, neonatorum caused by in divided
Romaxin, N. gonorrhoeae, C. doses.
Sansacne, trachomatis, and for
Sefavex, chlamydial
Stiemycin, conjunctivitis in
Upperzin neonates.

 Considered an
acceptable alternative
to penicillin for
treatment of
streptococcal
pharyngitis, for
 prophylaxis of
rheumatic fever and
bacterial endocarditis,
for treatment of
diphtheria as adjunct
to antitoxin and for
carrier state, and as
alternate choice in
treatment of primary
syphilis in patients
allergic to penicillins.

 Topical applications:
Pyodermas, acne
vulgaris, and external
ocular infections,
including neonatal
chlamydial
conjunctivitis and
gonococcal
ophthalmia.

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Name: Interferes with protein  Short-term Adults IM/IV: 3- History of CNS:
Gentamicin synthesis in bacterial cell by treatment of 5 mg/kg/day in hypersensitivity neuromuscular
binding to ribosomal subunit, serious infxns divided doses to or toxic blockade:
Brand Name: causing misreading of genetic caused by Obese patients: reaction with any weakness,
(Philippines) code; inaccurate peptide susceptible strains base dose on aminoglycoside arachnoiditis CV:
Adelanin, sequence forms in protein of estimate of lean antibiotic. Safe hypotension,
Garamycin, chain, causing bacterial death. microorganisms, body weight use during hypertension. GI:
Garamycin Route Onset Peak esp.,gram- Children IM/IV: pregnancy or Nausea, vomiting,
0.1% IM Rapid rapid neagative bacteria 6-7.5mg/kg/day lactation is not transient increase
Cream/Oint, ½-1 ½ Infusion’  Adjunct to Infants/Newborn established. in AST, ALT, and
Gentamytrex, IV : IM/IV 7.5 serum LDH and
hr s end systemic
Opthagen, gentamicin in mg/kg/day bilirubin;
Servigenta, serious CNS Premature and hepatomegaly,
Topigen, infxns term newborns: splenomegaly.
Topigen Eye  Treatment of IM/IV Hematologic:
drops, superficial ocular 5mg/kg/day or Increased or
Sannogen and skin infxns 2.5mg/kg every decreased
 Infxn prophylaxis 18 hrs or 3mg/kg reticulocyte
and aid to healing. every 24hrs. counts;
granulocytopenia,
thrombocytopenia
(fever, bleeding
tendency),
thrombocytopenic
purpura, anemia.
GU:
Nephrotoxicity:
proteinuria,
hematuria, rising
BUN, nonprotein
nitrogen, serum
creatinine;
decreased
creatinine
clearance. Other:
Local irritation and
pain following IM
use;
hypersensitivity,
fever
 Name of the Contraindication Adverse
Action Indications Dosages
Drug s Reactions
Generic Name: Accelerates formation of  Prophylaxis By intermittent Aspirin should be GI: diarrhea
Heparin antithrombin III-thrombin complex and treatment IV inj, IV avoided by Hematologic:
and deactivates thrombin to prevent of infusion or deep patients receiving hemorrhage
Brand Name: conversion of fibrinogen to fibrin. thromboemboli SC inj. Adult heparin therapy. Other: allergy,
(Philippines) Anticoagulant. Decreases the ability c disorders low dose If an analgesic is anaphylactic
Contractubex, of blood to clot. such as prophylaxis required, reaction
Heparin Leo Rout Onse Peak Duratio thrombophlebit against venous acetaminophen
e t n is, pulmonary thromboemboli would be
2- unknow embolism, sm in patients acceptable
SC ½-1hr
4hrs n coronary or undergoing substitute.
imme unkno unknow venous surgery: Hypersensitivity
IV initiated about 2 to heparin. Actual
diate wn n thrombosis,
and occlusive hrs prior to or potential
vascular surgery. Usual hemorrhagic
disease. dose: 5000IU by states. Threatened
 Prevention of deep SC inj, abortion, subacute
thromboemboli repeated every 8- bacterial
c 12hrsfor 7days endocarditis,
complications following severe
arising as a surgery or until hypertension,
result of patient is gastric or
cardiac and ambulatory duodenal ulcers,
vascular Continuous IV advanced hepatic
surgery , infusion: bolus or renal disease.
frostbite dose of 5000IU
 Anticoagulant may be given
during blood initially followed
transfusions by an infusion of
20,000-40,000IU
in 1L NSS or
glucose infusion
 over 24hrs.
Intermittent IV
inj: initial dose
of 10,000 IU
followed by
5,000-10,000 IU
every4-6 hrs.

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Name: Glucocorticoid w/ anti-  Replacement Give medication Sytemic fungal CNS: depression
Hydrocortision inflammatory effect because of its therapy in with food. With infections. IM use CV: hypertension,
e ability to inhibit prostaglandins adrenocortical large doses, in idiopathic circulatory collapse,
synthesis inhibit migration of insufficiency administer thrombocytopenic tachycardia,
EENT: blurred
Brand Name: macrophages, leucocytes, and  Treatment of antacids between purpura.
vision,
(Philippines) fibroblasts at sites of inflammation, rhemumatic meals. Psychosis, acute
GI: diarrhea,
Cortizan, phagocytosis and lysosomal enzyme disorders, Adrenal glomerulonephriti
nausea, abdominal
Drugmaker’s release. It can also cause the collagen insufficiency/inf s, amebiasis,
distenstion,
Biotech reversal of increased capillary diseases, lammation: noanasthmatic
increased appetite,
Hydrocortisone permeability. dermatologic Adult: PO 5-30 nronchial disease,
pancreatitis
, Efficort, Rout Onse Peak Duratio disease, mg 2x/4x a day. children <2yrs, Hematologic:
Hydrotopic, e t n allergic states, IM/IV 100- AIDS, TB hemorrhage,
Hydrotopic 1- 1 ½ days respiratory 250mg, then 50- thrombocytopenia
Injection, PO 1hr 100 mg IM as
2hrs disease, Skin: petechiae,
Lacticare-HC 20mi 4- 1 ½ days hematologic needed. IM.IV ecchymosis
Lotion, Pharex IM 15-240mg every
ns 8hrs disease,
Hydrocortisone ukno 1 ½ days neoplastic 12 hrs.
, Pharmacort, IV Rapid Shock: Adult:
wn disease,
Phoenix multiple 500mg-2g every
Hydrocortisone sclerosis, 2-6 hrs
Sodium tuberculous
Succinate, meningitis
Solu-Cortef  Treatment of
 synovitis of
osteoarthritis
ans symptoms
of rheumatoid
arthritis,
bursitis, acute
gouty arthritis,
ericondylitis

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Name: Decreases blood glucose; by  Management Maintenance Hypoglycemia, Skin: redness,
Insulin transport of glucose into cells and of type1 DM dose: given SC, insulinoma, itching, hives,
the conversion of glucose to and type2 DM dose determined hypersensitivity selling,
Brand Name: glycogen indirectly increases blood which cannot by the physician reactions, IV inflammation,
(Philippines) pyruvate and lactate, decreases be controlled depending on the administration of
Novomix 30 phosphate and potassium by diet, requirement of insulin
FlexPen, exercise or the individual suspension ,
Levemir, weight patient. diabetic coma.
Actrapid HM, reduction alone Administer
Humulin R, before meals and
Humulin N, after soon after
Insulatard HM, meal when
Scilin N necessary.
Regular Insulin:
given IV/Im for
severe
ketoacidosis or
diabetic coma

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Name: As a glucocorticoid, it has marked  Suppression of Take with food. Systemic fungal Musculoskeletal
Methylprednisolo anti-inflammatory action due to its inflammatory Vial: adjuvant infections. Septic effects, GI effects,
ne ability to inhibit prostaglandin and allergic treatment of shock. skin reactions,
synthesis. As an disorders, life-threatening Hypersensitivity, negative nitrogen
Brand Name: immunosuppressant, it cerebral states: 30mg.kg administration of due to protein
catabolism, nervous
(Philippines) inhibitsphagocytosis, and migration edema, BW given in 30 live/live
system effects,
Adrena, of macrophrages and leukocytes to rheumatic mins IV attenuated seizures, psychic
Advantan, Depo- the site of inflammation as well as disease, infusion, can be vaccine. disorders.
Medrol, Medixon, stabilizes lysosomes to prevent immunosuppre repeated in the Lactation.
Medrol, Solu- release of enzymes and reverses ssant in spinal 1st 48-72hrs in 4- Premature infants.
Medrol increases capillary permeability. cord injury. 6hrs intervals. Tuberculous or
Rout Onse Peak Duratio  Atopic RA: 0.5-1g/day syphilitic
e t n dermatitis, for 1-4 days or processes in the
1- 30-36hrs contact 1g/mo for 6mos area to be treated.
PO rapid SLE: 0.5-1g/day Viral disease.
2hrs eczema,
6- unkno 4-8days degenerative, for 3 days.
IM Multiple
48hrs wn dyshidrotic,
imme imme unknow vulgar eczema, Sclerosis:
IV and eczema in 1g/day for 5 days
diate diate n
children. Edemic States:
 Osteoarthritis, 30mg/kg BW
bursitis, every 2nd day for
rheumatoid 4 days or 0.2-
arthritis, 1g/day for 3-5
tendinitis, days
epicondylitis, Terminal Stage
ulcerative of Malignant
colitis, acute disease:
gastroenteritis, 125mg/day for
or in pre- or 8weeks
post-operative
 Neoplastic
diseases
 Allergic and
 edematous
states

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Name: Broad spectrum antibiotic, believed  Bacteremia, Normal Renal Pregnancy. Nephrotoxicity,
Netilmicin to inhibit protein synthesis by Septicemia, Function: adult Hypersensitivity. neurotoxicity, local
binding irreversibly to the 30S neonatal sepsis 50-90 kg: 150mg reactions, GI effects
Brand Name: subunit of bacterial ribosome  Skin and soft 12 hrly; 40- and fever.
(Philippines) thereby interfering with the tissue, bone 60kg: 100mg 12
Netromycin initiation complex between and joints hrly.
messenger RNA and 30S subunit. infections. Pedia: 2-
Polyribosomes are split apart and  BuRns, 2.5mg/kg every
are unable to synthesize protein. It wounds, and 8hrs
also causes disruption of the peri-op infxns. Infants/Neonate
bacterial cytoplasmic membrane s: >1wk: 2.5-3.0
leading to cell death. mg/kg every 8
Rout Onse Peak Duratio hrs.
e t n
IV/I imme 30-60 12-24
M diate mins hrs

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Name: Inhibits bacterial cell wall synthesis  Treatment of Adult: 400,000- Hypersensitivity. Hypersensitivity
Penicillin G, during bacterial multiplication. respiratory 800,000 units reactions,
Benzyl Penicillin Rout Onse Peak Duratio tract infection, every 6hrs sensitizations, mild
e t n skin and soft Pedia 7-12 yrs: GI irritation.
Brand Name: imme Imme unknow tissue infxns, 40,000-800,000
(Philippines) IV units/kg BW/day
diate diate n dental and
YSS imme 15-30 unknow surgical infxns. in divided doses
Benzylpenicillin IM every 6 hrs
diate mins n  Some types of
Sodium PO imme 1hr unknow sub-acute Intermittent IM
 diate n bacterial inj. Or IV
endocarditis, infusion:
meningitis, Serious acute
otitis media, infxns with or
and without
osteomyelitis bacteremia:
300,000-600,000
units 4 hrly.
Pneumococcic
pneumonia: IM
500,000 units
12hrly
Gonorrhea: IM
300,000-600,000
units 4 hrly.

Name of the Contraindication Adverse

Action Indications Dosages
Drug s Reactions
Generic Name: Inhibits protein synthesis in  Part of the TB: 1g IM 2 or 3 Hypersensitivity. Allergic reactions,
Streptomycin bacterial cell by binding combination times wk or daily. Pregnancy disturbances of
directly to 30S ribosomal therapy of active Gonorrhea: 1 IM vestibular fxns,
Brand Name: subunit, causing inaccurate TB, used in inj of 0.3-0.5g paresthesia.
(Philippines) peptide sequence to form in combination with Subacute bacterial
Biolab protein chain, resulting in other agents for endocarditis: at
Streptomycin bacterial death. treatment of least 2g IMdaily
Sulfate Route Onset Peak streptococcal or divided doses for a
IM rapid 1-2hrs enterococcal minimum of 6
endocarditis, weeks
mycobacterial Brucellosis w/
infxns, plague, bacteremia: 1g IM
tularemia, and twice daily for 1
brucellosis. wk, then 1 g/day for
2nd wk.
UTI: 1-2.5g