ENDOCRINOLOGY

HORMONE NATURE SYNTHESIS RECEPTOR MECH OF

ACTION

GH Peptide 22kD Protein Cytokine GH

191 AA synthesis receptor GHRJAK2
Tyr Kinase.
Activates
STAT, Src
(RAS MAPK),
IRS, PLC

PRL Peptide 23kD -do- -do- -do-

198 AA

TSH Peptide, 2 Protein GPCRs cAMP

subunits (α synthesis pathway
and β),
(30kD)

LH, FSH, hCG -do- -do- -do- -do-

(25kD)

ACTH POMC, 39 AA -do- -do- cAMP with Ca

pathway

β-Lipotropin POMC -do- -do- -do-

91 AA

Endorphin POMC -do- -do- -do-

31 AA

MSH POMC -do- -do- -do-

Vasopressin Peptide Peptide V1 and V2 cAMP,

(ADH) 9 AA synthesis receptors adenylyl
(Cell cyclase
surface)
 HORMONE NATURE SYNTHESIS RECEPTOR MECH OF
ACTION

Oxytocin -do- -do- Cell surface ?

receptors

Thyroxine Tyrosine MIT, DIT & DNA Enhance or

derivative Iodine in Binding repress gene
thyroid (Nuclear) transcription
follicular
cell

PTH Peptide Peptide Single cAMP,

84 AA synthesis membrane adenylyl
receptor cyclase +
ptn - 70kD Calcium

Calcitriol Steroid Cholesterol Steroid Steroidal

derivative catabolism family mechanism
receptor (Binding to
with DNA nuclear
having Zn receptors and
Finger then to HREs
motif following
plasma
membrane
diffusion)

Cortisol, -do- -do- -do- -do-

Testosterone,
Oestrogen,
Progesterone

Epinephrine, Catecholamine Tyr β- cAMP,

norepinephrine metabolism adrenergic adenylyl
and Dopamine receptors cyclase

Relaxin Peptide Peptide GPCRs cAMP

synthesis

Insulin Peptide Peptide Cell surface cAMP, IP3,

synthesis receptors Glut 4
HORMONE NATURE SYNTHESIS RECEPTOR MECH OF
ACTION

Glucagon Peptide Peptide RTKS cAMP, IP3,

synthesis Glut 4

NO Inorganic gas Acetyl Cell surface cGMP

choline and receptors
calcium –
NOS

Atrial Peptide Peptide Cell surface cGMP

natriuretic synthesis receptors
peptide

GABA Glu derivative Glu Cell surface Chloride

metabolism receptors