BB Drug List

Anxiolytic
Buspirone- 5-HT1a partial agonist. GAD.
Epilepsy
Carbamazepine- Na channel blocker.
Pregabalin= binds to A2D Ca channel subunit.
Hypnotic, anxiolytic, insomnia treat. Anti
epileptic.
Ethosuxemide= T type Ca channel blocker
Depression + GAD
Citalopram= SSRI. Supress REM sleep.
Fluoxetine= SSRI. Sex dysfunction. Increased BP
Sertraline= SSRI. Remember autoreceptor, 2
weeks lag.
Mirtazapine- NaSSA.
Phenelzine- Non selective Irreversible MAO
inhibitor. Amitriptyline= TCA, SNRI, used for
huntingtons, pain. Sleep helping. Dizzy,
headache, confusion, insomnia, drowsy. Contra if
MI/arrhythmia
Moclobemide- Reversible MAOa inhibitor. Cheese.
PARKINSONS
L-DOPA- dopamine precursor basis of therapy.
Long term issues
Madopar- (Benserazide) Peripheral Decarboxylase
Inhibitor.

Rotigotine- dopamine like agonist. Transdermal

patch
Selegiline- Selective Irreversible MAObI. Inhibits
Dopamine Metabolism
Rasagiline- Irreversible MAObI.
Amantadine- NMDA antagonist, Increase
dopamine release, inhibit reuptake dopamine
Antipsychotic (also for GAD)
Risperidone- Atypical. 5-HT antagonist.
Olanzapine- Atypical antipsychotic. Fewer EPSE.
But T2D, HT, dyslipidaemia
Clozapine= D1,2,4 antagonist. Atypical
Antipsychotic. Agranulocytosis.
Haloperidol= Typical antipsychotic.
Chlorpromazine= Typical. D2 blockade.
Pain
Pregabalin= binds to A2D Ca channel subunit.
Hypnotic, anxiolytic, insomnia treat. Anti
epileptic.
Paracetamol= Decrease active oxidised COX2.
Modulates endogenous Cannabinoid.
Tramadol= mu opiod agonist. SRI+ NARI. NMDA
+ 5HT antag. M1,3, nicotinic, TRPV1 agonist.
Resp depression, psychosis, emesis, dizzy.
Diclofenac= NSAID. Phospholipase A2 inhibitor.
Lipoxygenase inhibitor. Long acting.
Ibuprofen= NSAID. Non selective.
Huntingtons

Tetrabenazine= synaptic vesicular amine

transporter inhibitor.
Antipsychotics= haloperidol, olanzipine
Antidepressants= amitryptiline
Headache
Sumatriptan- headaches. 5-HT1b/d agonists.
Methysergide- Prophylaxis for headaches. 5-HT2B
antagonist. Causes retroperitoneal fibrosis
Emesis
Ondansetron= Blocks 5-HT3 @ CTZ.
Domperidone= Peripheral D2/D3 antagonist.
Cardiotoxicity.
Granisetron = 5-HT3 antagonist. Reduces vagal
activity. Headache, dizzy, constipation.
Recreational
Caffeine Inhibits Phosphodiesterase +
adenosine A1 receptors=/= sleep via reticular
formation. Withdrawal syndrome.
Alcohol- 3 Phase severe withdrawal. Cellular
anaesthetics cross tolerance, pharma
barbiturates
Amphetamine- No withdrawal syndrome.
Sympathomimetric. Block MAO, promote
catecholamine release. High dose psychosis +

Cocaine- High dose psychosis. Potentiates

catecholamine. High dose stroke. Mydriasis.
Ecstasy (MDMA)- SNRI. Dehydration,
hyperthermia,
Heroin- Opiate. PAG, reticular depression, CTZ.
Cellular tolerant to emesis in a day. Constipation.
Pupil constriction.
Nicotine- No physical dependence. Promotes
reticular.