Lauren Michelle Stein

Department of Pharmacology & Physiology

Saint Louis University School of Medicine
1402 South Grand Boulevard, Saint Louis, Missouri 63104
Office: (314) 977-6347 Cell: (314) 322-8871
lstein1@slu.edu

EDUCATION
2004-2008

Bachelor of Science in Biology

University of Missouri, Saint Louis, Missouri

2012-present

Doctoral Candidate in Pharmacology & Physiology

Saint Louis University School of Medicine, Saint Louis, Missouri
Expected Graduation Date: May 2016

RESEARCH EXPERIENCE
2005-2006

Undergraduate Research Assistant (Advisor: Dr. G.C. Carlson),

Department of Physiology, A.T. Still University,
Kirksville, MO

2007-2008

Undergraduate Research Assistant (Advisor: Dr. C. Macdiarmid)

Department of Genetics, University of Missouri-St. Louis,
St. Louis, MO

2009-2010

Research Technologist II (Advisor: Dr. J. Tichelaar)

Department of Surgery, Washington University - St. Louis,
St. Louis, MO

2010-2011

Research Technologist II (Advisor: Dr. J. Tichelaar)

Department of Pharmacology & Toxicology, Medical College of
Wisconsin, Milwaukee, WI

FUNDING
INTRAMURAL FUNDING
Graduate Program in Biomedical Sciences Funds
Saint Louis University 7/1/12-6/31/14
Amount: $28,000 per year
EXTRAMURAL FUNDING
NIH T32 Training Grant
7/1/14 6/30/15
Amount: $36,624

TEACHING EXPERIENCE
2014-present

BBS 502, Special Topics in Basic Biomedical Sciences (2 hours per

semester) Literature survey course taken by first year graduate
students to discuss assignment manuscripts. Facilitate critical
evaluation on study rationale, methodologies used, results, and
interpretation of data.

2014-present

BIOL 145: Drugs We Use and Abuse (3-4 hours per semester)
Team-taught undergraduate course introducing the fundamentals of
drugs and their effects on the body. I cover cardiovascular and
diabetic drugs, asthma and allergies, and hormonal contraceptives
as well as a systems overview lecture.

2015

PPY 2545, Human Physiology, Reproductive Physiology Section (1

hour per semester) A team-taught introductory course in the
fundamental mechanisms of human physiology. My lecture
provided an overview of male reproductive physiology including
anatomy, androgen synthesis and mechanism of action, male
reproductive life cycle, and feedback regulation of gonadotropin
secretion.

2015

BBS 503, Basic Biomedical Science, Classical Genetics Section (4

hours per semester) A team-taught survey course covering a wide
range of topics in biomedical sciences to provide first year graduate
students with a foundational knowledge base. My lectures cover a
range of topics including Mendelian genetics, genetic linkage,
heredity and inheritance patterns, quantitative genetics, and
techniques in molecular genetics.

SERVICE
2013

Judge

Academy of Science St. Louis Science Fair

2013 - current

Mentor

Undergraduate Pre-Med Student Research

2015 - current

Member

APS Animal Care and Experimentation

Committee

2015 - current

Member

APS Sex and Gender Differences Interest

Group

2015- current

Reviewer

AJP: Regulatory, Integrative, & Comparative

Physiology

SPECIALIZED EDUCATION
2016

Certification Course in University Teaching Skills, Saint Louis University

2015

Mouse Metabolic Phenotyping Core (MMPC) Glucose Clamping Course,

Vanderbilt University, Nashville, TN.

2014

APS Sponsored Best Practices for Publishing Workshop, Orlando, FL

2014

TOPRA Webinar Series An Overview of US and EU Regulatory

Processes

PUBLICATIONS
PEER-REVIEWED
(1)
Lim PH, Pisat NP, Gadhia N, Pandey A, Donovan FX, Stein L, Salt DE, Eide DJ
and MacDiarmid CW. Regulation of Alr1 Mg transporter activity by intracellular
magnesium. PLoS One. 2011;6(6):e20896. doi: 10.1371/journal.pone.0020896
(2)

Vikis HG, Gelman AE, Franklin A, Stein L, Rymaszewski A, Zhu J, Liu P,

Tichelaar JW, Krupnick AS, and You M. Neutrophils are required for 3methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung
carcinogenesis. Mol Carcinog. 2012 Dec;51(12):993-1002. doi:10.1002/mc.
20870

(3)

Carlson CG, Stein L, Dole E, Potter RM, Bayless D. Agents Which Inhibit NF-B
Signaling Block Spontaneous Contractile Activity and Negatively Influence
Survival of Developing Myotubes. J Cell Physiol. 2015 Jun; doi: 10.1002/jcp.
25085

(4)

Yosten GL, Elrick MM, Salvatori A, Stein LM, Kolar GR, Ren J, Corbett JA, and
Samson WK. Understanding peptide biology: The discovery and characterization
of the novel hormone, neuronostatin. Peptides. 2015 Oct; 72:192-5. doi:10.1016/
j.peptides.2015.05.011

(5)

Elrick MM, Samson WK, Corbett JA, Salvatori AS, Stein LM, Kolar GR, Naatz A,
Yosten GLC. Neuronostatin acts via GPR107 to increase cAMP-independent
PKA phosphorylation and proglucagon mRNA accumulation in pancreatic alpha
cells. Am J Physio Regul Integr Comp Physiol. 2015 Nov; doi: 10.1152/ajpregu.
00369.2014

(6)

Hong J, Zheng W, Speth R, Verbalis J, Stein L, Yosten G, Samson W, and

Sandberg K. Aging-related impairments of urine concentrating mechanisms
correlates with dysregulation of adrenocortical angiotensin type 1 receptors in

male Fisher rats. Am J Physio Regul Integr Comp Physiol. 2015. doi: 10.1152/
ajpregu.00131.2015.
(7)

Stein LM, Yosten GLC, Samson WK. Adropin Acts in Brain to Inhibit Water
Drinking: Potenital Interaction with the Orphan G Protein-Coupled Receptor,
GPR19. Am J Physio Regul Integr Comp Pysiol. 2016. doi: 10.1152/ajpregu.
00511.2015.

PUBLICATIONS IN PREPERATION
(1)
Stein LM, Tullock C, Elias C, Samson WK, and Yosten GLC. Hypothalamic
Action of Phoenixin to Control Reproductive Hormone Secretion: Importance of
the Orphan G Protein-Coupled Receptor GPR173. (2016) In Preparation.
(2)

Stein LM and Yosten GLC. A match made in heaven: A novel strategy for
matching orphan receptors with their ligands. Invited Review for American
Journal of Physiology-Regulatory, Integrative, and Comparative Physiology.
(2016) In Preparation.

RESEARCH ABSTRACTS
(1)

Stein LM, Samson W.K., Yosten G (2014) Adropin Enhances Glucose Disposal
and Vascular Function in Rats, Experimental Biology, San Diego, CA.

(2)

Stein LM, Yosten G, Ananthakrishnan K, Vagner J, Lynch R, Samson WK (2014)

GLP1-Linked to an 2-Adrenergic Antagonist Enhances Glucose Disposal,
Experimental Biology, San Diego, CA.

(3)

Stein LM, Mathews S, Samson W.K., Yosten G (2015) Evidence of an

Interaction Between GPR173 and the Novel Reproductive Peptide Phoenixin,
Graduate Student Association Research Symposium, St. Louis, MO.

(4)

Stein LM, Samson WK, and Yosten GLC (2015) Identification of a Candidate
Adropin Receptor, Experimental Biology, Boston, MA.

(5)

Samson WK, Stein LM, and Yosten GLC (2015) Targeting the Alpha Cell in
Hypoglycemia, Annual Meeting of the Society for the Study of Ingestive
Behaviors, Denver, CO.

(6)

Stein LM, Yosten GLC, and Samson WK (2015) Investigation into the
Autonomic Actions of the Novel Peptide Adropin, Annual Meeting of the Society
for the Study of Ingestive Behaviors, Denver, CO.

(7)

Stein LM, Mathews SK, Samson WK, and Yosten GLC (2015) A Novel, Master
Switch for Ovarian Cyclicity: The Impact on Cardiometabolic Health, APS
Physiology & Gender Conference, Annapolis, MD.

(8)

Stein LM, Yosten GLC, Samson WK (2016) A Novel Hypothalamic Action of

Adropin: Regulation of Fluid Homeostasis, Experimental Biology in San DiegoM,
CA

INVITED PRESENTATION
(1)

Experimental Biology in Boston, MA (2015) Metabolic Effects of the Novel

Peptide Adropin and Identification of a Candidate Receptor

(2)

Swiss Winter Conference on Ingestive Behavior in St. Moritz, Switzerland (2016)

Water We Have Here? A Potential Interaction Between Adropin and Gpr19

(3)

Experimental Biology in San Diego, CA (2016) APS Featured Topic Session on

Hormones and Reproduction

AWARDS
2015

AJP Regulatory, Integrative and Comparative Physiology Sponsored

Outstanding Abstract Award at APS Conference: Cardiovascular, Renal
and Metabolic Diseases: Physiology and Gender in Annapolis, MD

2015

Second Place Poster Presentation at the APSA Midwest Regional Meeting

in St. Louis, MO

2015

APS Abstract Travel Award for APS Conference: Cardiovascular, Renal

and Metabolic Diseases: Physiology and Gender in Annapolis, MD

2015

Endocrinology & Metabolism Section Mead Johnson Research Award at

Experimental Biology in Boston, MA

2015

Inaugural Thomas C. Westfall Fellowship Award, Department of

Pharmacology & Physiology, Saint Louis University

2016

Endocrinology & Metabolism Section Research Recognition Award at

Experimental Biology in San Diego, CA

2016

AJP Regulatory, Integrative and Comparative Physiology Sponsored

Travel Award at Swiss Winter Conference on Ingestive Behaviors in St.
Moritz, Switzerland

PROFESSIONAL & ACADEMIC SOCIETIES

2013 Present

American Physiological Society

2014 Present

American Heart Association

2014 Present

The Endocrine Society

2014 Present

Graduate Student Association, Departmental Representative (2015)

2015 Present

Society for the Study of Ingestive Behaviors