Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
20 yo woman with 8 yr
hx of intermittent HA's,
flashing lights in right
visual field, f/by
unilateral THROBBING
headache with
NAUSEA, vomiting,
with menses
2.
intense periorbital
pain, tears, rhinorrhea,
smoker, for 15 mins-3
hours
3.
80 yo old woman
fracture of femur given
morphine, soon her
resp's are 6/min, has
PINPOINT pupils,
serum Cr is 1.8mg/dL,
best explan of
intoxication in pt?
4.
5.
bulimia nervosa
patient treatment?
6.
chemotherapy regimen
for 55 yr old w non
hodgkin lymphoma is
vinblastine. normal
function of which cells
and tissues resistant to
this agent?
7.
8.
9.
10.
Friedreich ataxia
11.
friederich ataxia
12.
lesion is at the
lateral
corticospinal tract
(CST), if lesion in
the SC--always
motor deficit-IPSIlateral. so
here, RT sided
paresis due to
right side lesion.
13.
patient has
Schizophrenia-treat with
antipsychotic-risperidone
14.
previously healthy 52 yo F, 2 mo hx of
progressive difficulty swallowing,
double vision, and slurred speech.,
ptosis of the eyelids and waddling gait.
muscle strength shows fatigable
weakness of the neck, arms, hands, and
fingers. Repetitive nerve stimulation
shows a 25% decrease in muscle action
potentials in several muscles. Which of
the following mechanisms is the most
likely cause of this patients disease?
BINDING OF
AUTOAb to ACH
receptor BY AN
ANTIBODY-myasthenia
gravis
15.
BRIEF, PSCYHOTOIC
DISORDER, usually lasts
<1 month, SUDDEN
onset,
16.
DEGENERATION OF
MOTORNEURONS OF
LUMBAR CORD---either
ALS or poliomyelitis,
patient is presenting
with LMN lesion,
desruction of Anterior
horn
Pcom---posterior
communicating artery
rupture--The aneurysm
pressed on the
oculomotor nerve and
Trochlear Nerve. The
eye is blow bc the right
thing to be lost on
oculomotor compression
is parasympathetics
then the motor. The eye
can't adduct bc Superior
oblique helps with
adduction thats why its
difficult for people with
this paralysis to go down
stairs they can't look
medial and down.
17.
18.
19.
20.
Older asplenic
person with
meningitis --> knee
jerk streptococcus
pneumoniae
21.
Vincristine-mechanism-microtubules for
axonal transport
22.
WALK DAILY
23.
drinking from
home-distilled
liquor.--CHRONIC
ALCOHOL ABUSE--is
a risk factor for 2nd
gout
24.
this is NORMAL
development-tanner stage II
(pubarche--pubic
hair appears),
25.
schedule appts to
monitor patient;
26.
VITAMIN E!!!!
27.
no cap-->still
translated because
of PRESENCE OF
INTERNAL
RIBOSOME ENTRY
SITE--located in the
5'UTR (untranslated
region).
28.
29.
table shows
intermediates of
glycolytic pathways,
asks what would be
inhibited indirectly if
increased glucose
concentrations present
Glyceraldehyde-3-phosphate
dehydrogenase is the right one,
because 1,3-bisphosphoglycerate
and pyruvate are the only ones
<100% and are both downstream
the enzyme Glyceraldehyde-3phosphate dehydrogenase (in
glycolysis pathway). clearly drop
in glucose conc seen from fructose
1 6 bisphosphate to
glyceraldehyde 3 phosphate and
so on
37.
protein degradation--Polyubiquitination
30.
hypoglycemia, lethargy,
diarrhea of 18 month
old, Increased
DICARBOXYLIC ACIDS,
given medium chain
TG's for 6 months after
he became responsive
to IV tx, what is
deficient?
38.
natural
TRANSFORMATIONrmbr ADDITION OF
Dnase
39.
31.
MCAD deficiency
32.
hypoketotic,
hypoglycemic +
accumulation of 16C's
FA (eg. palmitate)
40.
hypotonia,
hypoketotic,
hypoglycemia,
myoglobinuria, muscle
weakness,
Carnitine deficiency--CAT-1
deficiency
antagonizes VLDL
cholesterol secretion-NIACIN
41.
34.
symptoms/presentation
similar to mcardles,
except they occur after
PROLONGED excercise
MCAD deficiency
35.
location of Acyl
transferase? CAS-II?
36.
33.
42.
43.
45.
46.
JEJUNUM
60 yr old w no history of
bleeding has coagulation
testing prior to coronary
artery bypass grafting. His
prothrombin time is 11.5 sec
(INR=1.0) <-whats inr?
and activated partial
thromboplastin time is 160
secs. what inflamm resp is
abnormal?
44.
47.
48.
49.
50.
t-lymphocyte
deficiency.
Parathyroids are
gone and thymus is
gone.
51.
unbalanced
chromosomal
arrangement
52.
Leukomoid reaction
53.
TUBEROUS
SCLEROSIS
54.
55.
56.
Blood-gas partition
coefficient--measure of the
solubility of the inhalation
anesthetic in the blood
relative to its solubility in the
inspired air. Circulating
blood provides the means of
anesthetic delivery to the
brain and the partial
pressure determines the
rate of transfer into the CNS.
The solubility of an agent in
blood determines how
rapidly the partial pressure
rises in the blood
57.
58.
MELAS ( mitochondrial
encephalomyopathy, Lactic
acidosis and stroke like
episodes) as in this clinical
vignette are mitochondrial
inherited. Variable
expression in mitochondrial
inherited disease is called
heteroplasmy.
To determine whether
children of workers in a lead
foundry sustain neurological
damage from exposure to
dust on their parent's
clothing, a test for motor
skills was given to 30 first
graders whose parents has
worked at the foundry for 5
years or longer and to 30
controls. Which of the
following groups of children
would be the proper control
group for this study
59.
60.
61.
pelvic parasympathetic
PLEXUS, this is why
these pts are at great
risk of impotence
63.
lateral (external)
rotation
KIDNEY
65.
labs? premenopausal-increased
FSH and LH,
decreased
estrogen.
66.
Surgical
removal of
the
suspected
tumor
64.
67.
A ) Deletion in
the short arm
of
chromosome
15
B ) Duplication
within
chromosome
15
C ) Large
trinucleotide
repeat
expansion in
the PWS area
of
chromosome
15
D ) Maternal
origin of both
chromosomes
15
E)
Translocation
in the short
arm of
chromosome
15
68.
INABILITY TO
PRODUCE
MELANIN
69.
Congenital
Diaphragmatic
Hernia
70.
CALCIUM--work up
every pt with a
gastrinoma for
MEN1, which will
include serum
calcium
(parathyroid
tumors?), PTH, and
pituitary hormones.
71.
Decreased function
of Na/K ATPase,
because there is
insufficient ATP due
to decreased
oxidative
phosphorylation
72.
ULCERATIVE
COLITIS
dextromethorphan,
codein analog that
is an opiate taht can
cause constipation
73.
74.
75.
COSTOCHONDRITIS
76.
substance P
77.
FIBRILLIN--marfans
78.
URETERS--water
under the bridge!!!!!!
79.
80.
s"influx of macrophages
producing IL1, IL6, TNF
alpha"--. decrease in
expression of adhesion
molecules on vascular
endothelial cells,
decrease in serum C
reactive protein
concentration, influx of
macrophages producing
IL1, IL6, and TNF alpha,
Lysis of endothelial cells
by the alternative
compliment pathway,
vasoconstriction. first
part of the reaction is
mediated by histamine.
Six hours later, your
body essentially has a
foreign body reaction to
the venom, which is why
macrophages
81.
amphoterecin B
82.
83.
...
84.
85.
It was neuronal
degeneration from
chronic traumatic
encephalitis (since he
was a pro boxer, he
got hit in the head a
bunch of times)
86.
sildenafil
87.
increased HCT
88.
NOT SENSITIVE
89.
anamolous origins of
multiple renal
arteries to each
kidney
90.
increased RER
because products
back up
91.
candida
92.
ureteral calculous is
causing the problem
93.
remove the
gastrinoma
94.
chronic pyelonephritis
95.
NADPH OXIDASE
97.
ligamentum flavum
98.
Mucus Production
and Secretion up
96.
in response to
cigarette smoke,
combustible fumes
and etc mucus
production always
increases. Just think
of the reid index in
chronic bronchitis,
the submucosal
mucous glands
increase in size in
response to cigarette
smoke because they
are secreting more
mucous in order to
clear all those nasty
inhaled carcinogens
99.
the inhaled
carcinogens
from cigarette
smoke
damage the
lining of the
alveoli. in
response to
this alveolar
macrophages
aggregate to
clear up the
mess
100.
this one
should be
easy.
carcinogens
in cigarette
smoke
destroy cilia
cells lining the
airway.
101.
Normal oral
flora.
Homeless
person + poor
dentition +
lung infection
= aspiration
pneumonia.
Aspiration
involves
infection with
normal oral
flora.
102.
IMA
103.
antithromin
III activation
104.
Ondansetron.
Good for
post-chemo
AND postsurgical.
105.
106.
lysosomes--i
cell disease
T
lymphocytes.
Tumor cells
are killed by
CD8+ T cells
and NK cells;
better
answer
between the
two (if you're
unlucky) is
CD8+ T cells
107.
pericarditis
108.
MESNA
fasting
serum
glucose
(patient has
metabolic
syndrome)
ATROPHY,
By taking
thyroxine,
she'll cause
TSH levels to
go down,
which will
reduce
thyroid
stimulation.
109.
110.
111.
wegener's
granulamoutsosis
112.
113.
Decreased lamellar
bodies. Lamellar
bodies are
secretory
organelles. The
type II
pneumocytes
make surfactant,
and this infant has
respiratory
distress syndrome,
so they're not
secreting as much
114.
Crescentic =>
RPGN. Often
caused by
goodpasture's,
which is Abs
against basement
membrane. It
often has lung
involvement as
well.
115.
Indomethacin
closes the PDA by
inhibiting
production of
PGE2, which is an
arachidonic
derivative and
therefore made by
Cyclooxygenase
(COX). Therefore,
COX is the answer
116.
122.
(HSV) genital
herpes-painful,
multiple,
penile, vulvar
or cervical
vesicles and
ulcers, other
sx's:
F/HA/myalgia
117.
NORMAL AGING.
decreased creatinine
clearance over 10 years is
just a loss of nephrons
with age, which has been
compensated for by
angiotensin and
aldosterone to prevent
serum creatinine from
rising overall.
123.
CIMETIDINE
124.
feces--ascaris
lumbroicodes
118.
119.
calcium
125.
streptococcus
pneumoniae
120.
hyponatremia, I think,
because of SIADH from a
small cell carcinoma
126.
DEAD SPACE
121.
64 yo old alcoholic,
disoriented, jaundice, spider
angiomatas, flapping of hands
up and down when
outstretched, neomycin
admin, mechanism?
127.
INFLUENza
128.
parietal cells
129.
pseudomonas
translation of
ferritin mRNA
130.
134.
135.
TNF-alpha
inhibitor
136.
VENOUS HTN-external
hemorrhoids, very
painful
137.
132.
133.
dna
polymerase
138.
chediak
hegashi recurrent
infections +
partial
albinism +
peripheral
neuropathy
PRAZIQUANTEL--parasites (bendy
worms) are killed
by -bendazoles
(bendy drugs) or
praziquantel
139.
causes of BPH
include UTI--mcc is
E.coli
140.
Evaporation of
sweat
141.
en - fu - virtide
inhibits fusion.
prostate--osteoblastic
lesion mets to
prostate
143.
144.
Leukotrines in general
cause asthma
145.
volume depletion
142.
146.
147.
...
148.
...
149.
)38 yo woman comes to physician for preemployment exam; she has no history of
serious illness; she takes no meds; her vitals
are normal; PE shows no abnormalities
irondeficiency
microglial =
macrophage
in brain
151.
Donor T
lymphocytes
152.
erythrocyte
spectrin
153.
right opthalmic
154.
myxoma
155.
protein structure
156.
15 yr old female ingested Vit D in a suicide attempt. Follow up 1 month later show Ca [C] 10.4 (slightly
elevated) What is the mechanism of increased Ca.
Increased
absorption of ca in
GIT--Vitamin
promotes
absorption of Ca+
in the GIT
157.
case control study is conducted to explore a possible association between exposure to an herbicide and
the diagnosis of non hodgkin lymphoma. controls are matched to cases by age, gender, and race.
exposure status is determined by interviewing the subjects. on matched pair analysis, the odds ratio is 3.2
( 95% confidence interval : 1.4-5.4) which of the following is most likely to affect the validty of this study?
Biased
measurement of
the Exposure
158.
24 year old african american man comes to the physician because of a 3 month history of red bumps on
his face and chin. he says that the bumps are itchy and painful. physical examination shows hyper
pigmented papules over the cheeks, jawline, and neck. which of the following is the most likely
diagnosis?
pseudofolliculitis
barbea--razor
burn and African
americans get it
frequently