TO BE PRESENTED By: Z H A R Ly N G .

B A R R E T T O

ALPHAHERPESVIRINAE

General
Characteristics
of Herpes virus
162
Capsomere

Characteristics of
Alphaherpesvirinae

??

Double
stranded
DNA
Icosahedral
symmetry

Short
reproductive
cycle

Rapid
spread
Epithelial Cells

Profile:
Family: Herpesviridae
Subfamily: Alphaherpesvirinae
Genera:
- Simplexvirus
- Varicellovirus

Herpes Simplex
Virus 1

- Gingivostomatitis
- Herpetic Keratitis
- Encephalitis
- Herpes labialis

Herpes Simplex
Virus 2

- Neonatal Herpes
- Genital Herpes

Varicella-zoster
virus

- Varicella or
chicken pox
- Zoster or shingles
- Neonatal infection

Acute
Gingivostomatitis
It occurs most frequently in small
children (1-3 years of age)
- extensive vesiculoulcerative
lesions of the mucous membranes
of the mouth,
- Fever
- Irritability
- local lymphadenopathy.

Herpetic
Keratitis
- The characteristic
lesions are dendritic
ulcers.
- Deep stromal involvement
may result in visual
impairment.

Encephalitis
-
-

lesion in the temporal

lobe.
Pleocytosis (chiefly
of lymphocytes) is
present in the
cerebrospinal fluid

Herpes
Labialis
-

-
-

small blisters or
sores on or around
the mouth
remains dormant in
the facial nerves
reactivating to create
sores in the same
area of the lips

Neonatal
Herpes

3 Forms:
A. SEM herpes
B. Disseminated herpes
C. CNS herpes

Genital
Herpes

Decreased appetite
Fever
General sick feeling
Muscle aches in the lower
back, buttocks, thighs, or
knees
Swollen and tender lymph nodes
in the groin

Varicella /
Chicken pox
- pain in the joints
- headaches
- mild fever
- rash of red pimple that
form scab

Zoster /
Shingles
- often appears as a single
stripe of blisters
- Pain, burning, numbness or
tingling
- Sensitivity to touch
- Fluid-filled blisters that
break open and crust over
- Itching

Neonatal
Infection
Congenital varicella
syndrome:
Scarring of skin
Hypoplasia of
limbs
CNS and eye
defects
Death in infancy
normal

Treatment and Prevention

Antiviral medicines
- valacyclovir (Valtrex)
- famciclovir (Famvir)
- acyclovir (Zovirax).
Safer sexual practices