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Replacement
Michael Tramontozzi, Chelsea
Benzie, Hallie Charapp,
Charles Baker, Michael
Chacko
1) Femoral Cap
2) Tibial Stem
Insert *
5
3) Tibial
4) Femur
5) Articular
Surface
Biocompatibility
FMEA
Osteointegration
Structural Design
BMP infused
Microspheres
Biodegradable Cement
Decreased Aseptic
Loosening
~5 mg
60 Day release
Spray Drying
Microsphere Diameter between 200-300m Chitosan
Controllable crosslinking
Biocompatible (natural
polymer)
Inexpensive
Cation forming
polyelectrolyte complexes
Well-studied
http://www.ece.illinois.edu/mediacenter/article.asp?id=346
http://www.pharmainfo.net/reviews/spray-drying-review
Spray Drying
Supported by most large
pharma companies
Inexpensive and good
Biodegradable Cement
Polypropylene Fumarate (PPF) porous, unsaturated linear polyester
Increased compressive properties with 65% concentration gypsum
(sulfate mineral)
Cross-linking capabilities with N-vinylpyrrolidone (NVP) and methyl
methacrylate (MMA)
Biodegradability
o 50-60% weight loss after 60 days
PPF vs. PMMA
o Elasticity Modulus => 395 MPa vs. 2.28 GPa
o Yield Strength => 10.7MPa vs. 85 Mpa
In-vitro Success
Drill bit design to compensate for decreased properties
Application of PPF
3-4 mm of PPF
Surface Cementation allows for adequate fixation
while allowing BMP to release and bone formation
to occur.
Function
User
Costs
Biocompati
bility
Custom
Nesting/locking
Area for Articular
Surface
Additional Fluting
for Prosthetic
Stability
Titanium Baseplate
Modulus
of
Elasticity
(E)
110 GPa
Poissons 0.3
Coefficien
1)
F s = 1/2 m v2
t (v)
Impact Forces on
the Prosthetic
2) Moment = F*d
Moments Acting
Across the Joint
3) =*G
G=E/(2*(1+v))
Shear Forces
Biocompatibility
Concerns
Host response
Hypersensitivity, toxicity
Infection
Open wound can cause an infection
Exposed bone: 2.5% to 15% risk of infection
Thrombosis
May occur from an inflammatory response
In-Vitro Testing
Oxford Rig Cadaver Test
Supine Range-of-Motion Test
Benchtop Test of Constraint
In-Vivo Testing
Clinical trials using goats and lambs
(60 days)
FDA Classification
Class III
Drug delivery
New bio-degradable polymer
Screw implant mechanism
instead of press-fit
Works Cited
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC337
4549/
http://impascience.eu/bioencapsulation/340_contr
ibution_texts/2006-10-05_O4-2.pdf
http://www.sciencedirect.com/science/article/pi
i/S1742706110005805
http://www.google.com/patents/US6486232
http://www.ncbi.nlm.nih.gov/pubmed/22707817
http://www.ncbi.nlm.nih.gov/pubmed/8938235
http://
www.boneandjoint.org.uk/highwire/filestream/64454
/field_highwire_article_pdf/0/295.full-text.pdf
http://www.ncbi.nlm.nih.gov/pubmed/19280644