Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
DE VIDA
Estrs Oxidativo
NADPH oxidasa
Xantina oxidasa
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O.2
J Vasc Br 2004;3(4):357-66
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Disfuncin Endotelial
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10-5s
10-10s
17s
s-h
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H2O2
O.-2
O.-2
H2O2
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16
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Antioxidante
Halliwell y Whiteman
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Antioxidantes
Un ANTIOXIDANTE es una molcula que tiene la
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TRPX
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Bilirrubina
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Mecanismo antioxidante
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cido Ascrbico
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Polifenoles
Alcoholes fenlicos
Lignanos
Estilbenos
Flavonoides
cidos fenlicos
Secoisolariciresinol
Tirosol
Resveratrol
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cido glico
Flavonoides
Flavonol
Flavanona
Flavona
Flavanonol
Antocianina
Flavanol
Isoflavona
Chalcona
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ab
100
a
a
80
b
b
60
40
c
20
Control
0.1
10
Control: H2O2 20 mM
Quercetina
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Quercetina3glucuronido (Q3GA)
Shirai et al. Biosci. Biotechnol. Biochem. 66(5): 1015-1021, 2002
Q3GA as the major antioxidative metabolite in human plasma after the intake of quercetin.
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Los antioxidantes
reducen el estrs
oxidativo
Los antioxidantes
reducen la
enfermedad crnica
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Se suministr vitamina C (500 mg diariamente), E (600 IU interdiario), y betacaroteno (50 mg interdiario) y se evalu los efectos en resultados finales
combinados de infarto de miocardio (MI), paro, revascularizacin coronaria o
muerte por CVD entre 8,171 profesionales femeninas saludables a partir de 40
aos con historia previa de CVD o tres o ms factores de riesgo de CVD, el
seguimiento fue de un promedio de 9.4 aos, desde 1995-96 a 2005.
Conclusin. No se observ todos los efectos de las vitaminas C, E o betacaroteno sobre los eventos cardiovasculares entre mujeres de alto riesgo para
CVD.
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Paradoja Antioxidante
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Norton grape is one of the most important wine grapes in Southern and
Midwestern states and generates massive pomace byproducts. The objective of
this study is to characterize the antioxidant compounds and activity in Norton
grape pomace extract (GPE) and further assess the potential health promoting
properties of Norton GPE using an animal disease model. The total phenolic
content and anthocyanins in Norton GPE were 475.4 mg of gallic acid equiv/g
and 156.9 mg of cyanidin 3-glucoside equiv/g, respectively. Catechin and
epicatechin in GPE were 28.6 and 24.5 mg/g, respectively. Other major
antioxidants in GPE included quercetin (1.6 mg/g), trans-resveratrol (60 g/g),
gallic acid (867.2 g/g), coutaric acid (511.8 g/g), p-hydroxybenzoic acid (408.3
g/g), and protocatechuic acid (371.5 g/g). The antioxidant activity of GPE was
evaluated by oxygen radical absorbance capacity (ORAC) and was 4133 mol of
Trolox equiv/g. Male diet-induced obese (DIO) mice were randomly divided to
three treatment groups (n = 12): a normal diet (ND group), a high fat diet (HF
group), and the high fat diet supplemented with GPE (HFGPE group). After 12week treatment, mice in the high fat diet groups gained 29% more weight
than the ND group. The GPE supplementation (estimated 250 mg/kg bw/d)
lowered plasma C-reactive protein levels by 15.5% in the high fat diet fed mice
(P < 0.05), suggesting a potential anti-inflammatory effect by dietary GPE.
However, dietary GPE did not improve oxidative stress in DIO mice as
determined by plasma ORAC, glutathione peroxidase, and liver lipid peroxidation.
Metabolitos
ejercen
The results
showed that secundarios
GPE contained antioxidantes
significant antioxidants
and dietary GPE
exerted anefecto
anti-inflammatory
effect
in
diet
induced
obesity.
antiinflamatorio en la obesidad inducida por
la dieta.
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