For example, elevated depressive symptoms were associated with lower CD8 T-lymphocyte

counts and a higher rate of genital HSV-2 recurrence over 6 months (18). Depressive symptoms in
HIV-seropositive gay men were linked with decreased CD4 T-cell counts, increased B-cell counts,
and increases in an immune activation marker (HLA-DR) even when health behaviors and disease
stage were controlled.