MM point of view:

1.Two plants have to be created.

2. Activate valuation area(Plant)
2.These two plants have to be assigned to company code.
3.Purchase organization needs to be assigned to company code.
4.Plants needs to be assigned to purchase organization.
5.For each plant one storage location has to be created.
6.Material types have to be extended to these two plants.
7. . Automatic Account determination.
8. Valuation grouping code needs to be assigned to these two plants.
9. If Approval process (Release stratergy)configured for purchasing documents and if a
release characteristic is the plant, then you need to add new plant in the release strategies.
10. Data Migration:
a. Common materials have to be extended to these two plants.
b. Need to find out school specific materials.
c. New materials have to be standardized.
d. Material has to be extended to the newly created plant, if required.
Vendors and customers have to be created.