Alex Campbell

HISTORY

Discovered in 1944 by German American Doctor Franz Josef

Kallman.
Correlations between hypogonadism and ansomia had been
made as early as 1856.

WHAT IT IS

A delay or failure of the afflicted person to fully go

through or even begin puberty.
No sense of smell which is called ansomia

HOW IT HAPPENS

Its a recessive trait that causes a genetic mutation at the

KAL1 gene.
The KAL gene codes for a cell adhesion molecule which
triggers the migration of the sex hormone (GnRH) into the
hypothalamus.
Very rare though affects only 1 in every 10000 males and one
in every 50000 females

PHYSICAL EFFECTS

Incomplete sexual maturation

Males can often have an unusually small penis and
undescended testicles, absence of facial hair and deepening
of the voice, erectile dysfunction and infertility.
Females have little to no breast development and suffer from
primary amenorrhea

DIAGNOSIS

Usually diagnosed after an unusually long absence of puberty

as well as a realization of anosmia (no sense of smell)

TREATMENT

Usually diagnosed after an unusually long absence of puberty

as well as a realization of anosmia (no sense of smell)
Males are administered testosterone while the females are
given estrogen and progesterone.
The main health issue associated with KS is osteoperosis
(brittle bones). Therefore, patients undergo bone scans every
2- 3 years.