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Pharmacological Premedication is
administration of drugs orally or
intramuscularly 1 to 2 hours before the
anticipated induction of anesthesia
Goals for Pharmacologic Premedication
Primary Goals for Pharmacologic
Premedication
2. Anxiety relief ( anxiolysis)
3. Sedation
4. Analgesia
5. Amnesia
6. Antisalogogoue effect
7. Increase in gastric fluid pH
8. Decreased in gastric fluid volume
9. Attenuation of sympathetic nervous system
reflex responses
10. Decrease in anesthetic requirements
11. Prophylaxis against allergic reactions
• Secondary Goals for Pharmacologic Premedication
2. Decrease in cardiac vagal activity …anticholinergic
(atropine) just before the time of anticipated need
3. Facilitation of induction of anesthesia …. Not
necessary in view of availability of potent intravenous
induction drugs
Postoperative analgesia… better achieved with opioids
or the intravenous injection of an opioids just before
the time of anticipated need ( preemptive analgesia )
3. Prevention of postoperative nausea and vomiting …
intravenous injection of an antiemetic ( droperidol ,
ondansetron) just before the time of anticipated need
Drugs and Doses used for Pharmacologic Premedication
before Inaction of Anesthesia