AETAS Intellectual Property Solutions Your ref: 1.42/108/2/149 Our ref: SK/PCT 0018/UKM/ 10 28" November 2010 Attn: Prof Dato’ Dr Mohammed Noor Embi Pengarah, Pusat Inovasi Kolaboratif, Universiti Kebangsaan Malaysia, Post (Confirmation copy) 43600 UKM Bangi, 2% Reminder National phase Selangor Darul Ehsan. Dear Prof Dato’, Re: International Application No.: PCT/MY2010/000135 International Filing Date: 3°° August 2010 ‘Applicants: UNIVERSITI KEBANGSAAN MALAYSIA Title: VASCULAR RISK PREDICTION USING NON-INVASIVE OPTICAL TECHNOLOGY (PI 20097012) International Search Report (ISR) and a Written Opinion(WO) [ISR-WO] We are pleased to inform you that an ISR-WO of the International Searching Authority (ISA) in respect of the above-mentioned international application have been establish by the Australian Patent Office (AU) on 29™ October 2010(received report on 16" November 2010) In the ISR-WO of the ISA, the examiner considers the invention defined in claim 3 to be novel, and 1.9 capable of industrial applicability, However, the examiner found that all Claims 1,2,4-9 to be obvious i.e. not involving inventive step in light of the cited prior arts documents. We have extracted the cited prior art documents and enclosed herewith. Hf you wish to amend the claims under Art.19 PCT, any amendments are done with the date of mailing (date of mailing 29" October 2010) of the ISA. 2months after Alternatively, we could file a demand for an International Preliminary Examination (IPE) of the priority date. A demand is requesting for an International Preliminary Examination Authority ((1PEA) ‘to examine the above application. Indeed, a fee is to be paid to the (IPEA), this depends on which IPEA is chosen [Australia, Europe or Korea (KR)]. We wish to remind you that the deadline for filing a Demand for an International Report on Patentability (IPRP) for the captioned PCT application is 22™ month from the priority date ie by or befor¢3" June 2011, for most of PCT member countries. ‘Actas Intellectual Property Solutions Sdn Bh (Co No: 801386-W) 'No2-12, alan PIU 8/3, Perdana Business Centre,Bandar Damansara Perdans,47820, Petaling Jaya Selangor, Malaysia. p-6046 2321095 Telv03 83185253 Fax: +03 33180353, ‘Website: wow neta. com myABTAS Intellectual Property Solutions Please note that the ISR -WO of the ISA is not binding to any national patent offices in respect of novelty and non-obviousness. Hence, such national patent offices have different opinion regarding the relevancy of the citations. Therefore, most national patent offices will examine patent applications individually. However, some national patent office’s may consider this SR -WO Otherwise, if you do not choose to file 2 demand for IPE, then, you could either file @ national phase application (within 20" or 30" Month from the priority date); we would be glad to assist you in this matter. Indeed, the deadline to file the national phase application is estimate to end on 3 April 2013 (20" ‘Month)/ 3" February 2012 (30 Month).Enclosed is the time limits for entering national phase. Meanwhile, we have attached the ISR-WO of the above matter. We hope to receive your response for the followings: a) Amend the claims under Art.19 PCT, and/or; b) File a demand on either the 22” month (Please let us have your it time, which is at least 2 months before any above due date) and/or; structions at an appropriate ©) File a national phase (Please let us have your instructions at an appropriate time, which is at least 2 months before any above due date). Should you request us to be present and discuss with the inventors relating to the search report, we would be glad to assist, ‘Thank you for entrusting us with the application. Yours sincerely, 'AETAS IP Solutions Sdn.8hd. [Actas intellectual Property Solutions Sdn hd (Co No: 801386.) ‘No2-12, Jalen PIU 8/3,Perdana Gusiness Centre, Bandor Damansara Perdana,47820, Petaling Jaya Selangor, Malaysi. ‘HP: 46016 2121095 Tel:e03 83185253 Fax: +03 83180353 ‘Website: von actas.commySen, - nanan AETAS Intellectual Property Solutions ‘The diagrams below illustrate the options available to you at the moment as you have received the International Search Report (ISR) and Written Opinion (ISA-WO); Request fo Supplementary supplementary ways interstional International search an publication ~~ | phase (months) 0 12 16 = 18 19-22 28 = i mn pitt i Fite local File PCT International (optional) application application Searchreport File demand for International | & weitten international emp Preliminary | opinion preliminary report on ‘examination Patentability | | Report on state of the art (prior art 33 socuments and their relevance) + initial patentability opinion File a Local application: 04/08/2009 File a PCT: 03/08/2010 International Search report and Written Opinion: 29/10/10 International Publication: 03/02/2011. Deadline for filing amendments to claims: 03/01/2011, National Phase entry 1: (20" Month)- 03/04/2011 Filing for Oemand/ International Preliminary examination (IPR)-optional: 03/06/2011 National Phase entry 2: (30" Month)- 03/02/2012